Trial reportThe American journal of clinical nutrition2022
Vitamin D supplementation in chronic obstructive pulmonary disease patients with low serum vitamin D: a randomized controlled trial.
Trial report in The American journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02122627 (Prevention of Exacerbations in Patients With COPD Through Vitamin D Supplementation), which is not on this map. Cited by 26 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevention of Exacerbations in Patients With COPD Through Vitamin D Supplementation: a Randomized Controlled Trial
Who cites it
26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Vitamin D for the management of chronic obstructive pulmonary disease.The Cochrane database of systematic reviews · 2024Pooled it
- Improvement of Lung Function by Micronutrient Supplementation in Patients with COPD: A Systematic Review and Meta-Analysis.Nutrients · 2024Pooled it
- The effect of vitamin D supplementation on antibiotic use: a meta-analysis based on randomized controlled trials.Frontiers in nutrition · 2024Pooled it
- Negligible effect of vitamin D supplementation on exacerbation in patients with chronic obstructive pulmonary disease: meta-analysis.Biochemia medica · 2023Pooled it
- Efficacy of vitamin D supplementation on COPD and asthma control: A systematic review and meta-analysis.Journal of global health · 2022Pooled it
- Vitamin D in pulmonary disease.Breathe (Sheffield, England) · 2026Review
- Serum Vitamin D Levels, Systemic Inflammation, and Exacerbation Among Patients with COPD GOLD Group E.Biomedicines · 2026Article
- 25-Hydroxyvitamin D Deficiency Elevates the Risk of COPD Incidence and Mortality: A Large Population-Based Prospective Cohort Study.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026Article
- Predictive value analysis of diaphragmatic ultrasound evaluation for mechanical ventilation outcomes in patients with acute exacerbation of chronic obstructive pulmonary disease.BMC pulmonary medicine · 2025Article
- The potential role of 1,25(OH)Journal of inflammation (London, England) · 2025Review
- Non-pharmacologic Prevention of Acute Exacerbation Chronic Obstructive Pulmonary Disease.Tuberculosis and respiratory diseases · 2025Article
- Nonlinear association between serum 25-hydroxyvitamin D concentrations and lung function in the United States adult population with COPD.Scientific reports · 2025Article
- Review
- The Role and Clinical Significance of Vitamin D in Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2025Review
- Chronic obstructive pulmonary disease: in-depth analysis of microbiota association and innovative prevention and treatment approaches from the gut-lung axis perspective.Frontiers in immunology · 2025Review
- Clinical value of Vitamin-D combined with budesonide/formoterol and theophylline sodium glycinate sustained-release tablets in the treatment of chronic obstructive pulmonary disease patients.Pakistan journal of medical sciences · 2024Article
- Mechanisms of osteoporosis associated with chronic obstructive pulmonary disease.Journal of bone and mineral metabolism · 2024Review
- The Role of Nutrition in the Development and Management of Chronic Obstructive Pulmonary Disease.Nutrients · 2024Review
- Vitamin D Status and Longitudinal Changes in Body Composition in Patients with Chronic Obstructive Pulmonary Disease - A Prospective Observational Study.International journal of chronic obstructive pulmonary disease · 2024Observational
- Genetic information supports a causal relationship between trace elements, inflammatory proteins, and COPD: evidence from a Mendelian randomization analysis.Frontiers in nutrition · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitamin D deficiency is frequently found in patients with chronic obstructive pulmonary disease (COPD). Vitamin D has antimicrobial, anti-inflammatory, and immunomodulatory effects. Therefore, supplementation may prevent COPD exacerbations, particularly in deficient patients.
objectivesWe aimed to assess the effect of vitamin D supplementation on exacerbation rate in vitamin D-deficient patients with COPD.
methodsWe performed a multicenter, double-blind, randomized controlled trial. COPD patients with ≥1 exacerbations in the preceding year and a vitamin D deficiency (15-50 nmol/L) were randomly allocated in a 1:1 ratio to receive either 16,800 International Units (IU) vitamin D3 or placebo once a week during 1 y. Primary outcome of the study was exacerbation rate. Secondary outcomes included time to first and second exacerbations, time to first and second hospitalizations, use of antibiotics and corticosteroids, pulmonary function, maximal respiratory mouth pressure, physical performance, skeletal muscle strength, systemic inflammatory markers, nasal microbiota composition, and quality of life.
resultsThe intention-to-treat population consisted of 155 participants. Mean ± SD serum 25-hydroxyvitamin D [25(OH)D] concentration after 1 y was 112 ± 34 nmol/L in the vitamin D group, compared with 42 ± 17 nmol/L in the placebo group. Vitamin D supplementation did not affect exacerbation rate [incidence rate ratio (IRR): 0.90; 95% CI: 0.67, 1.21]. In a prespecified subgroup analysis in participants with 25(OH)D concentrations of 15-25 nmol/L (n = 31), no effect of vitamin D supplementation was found (IRR: 0.91; 95% CI: 0.43, 1.93). No relevant differences were found between the intervention and placebo groups in terms of secondary outcomes.
conclusionsVitamin D supplementation did not reduce exacerbation rate in COPD patients with a vitamin D deficiency.This trial was registered at clinicaltrials.gov as NCT02122627.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.