Evidence map›Paper›PMID 35383335›Full record

SynthesisNature neuroscience2022

Genetic variants associated with longitudinal changes in brain structure across the lifespan.

Rachel M Brouwer, Marieke Klein, Katrina L Grasby, Hugo G Schnack, Neda Jahanshad, Jalmar Teeuw, Sophia I Thomopoulos, Emma Sprooten, Carol E Franz, Nitin Gogtay and 191 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
125citing papers in PubMed, 5 pooled it
43.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

125 citing papers in PubMed, 5 syntheses or guidelines pooled it, 239 citations in OpenAlex.

  1. Pooled it
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  16. ADHD symptom trajectories and brain morphometry: A longitudinal analysis.medRxiv : the preprint server for health sciences · 2026
    Article
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65 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

201 authors at 20 institutions in 20 countries.

Rachel M BrouwerDepartment of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands. r.m2.brouwer@vu.nl.ORCID http://orcid.org/0000-0002-7466-1544
Marieke KleinDepartment of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
Katrina L GrasbyPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0001-8539-0228
Hugo G SchnackDepartment of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-4620-3853
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.ORCID http://orcid.org/0000-0003-4401-8950
Jalmar TeeuwDepartment of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
Sophia I ThomopoulosImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Emma SprootenDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-1691-9105
Carol E FranzDepartment of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA.
Nitin GogtayAmerican Psychiatric Association, Washington, DC, USA.
William S KremenDepartment of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-8629-5609
Matthew S PanizzonDepartment of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA.
Loes M Olde LoohuisCenter for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-3327-7837
Christopher D WhelanBiogen Research and Development, Cambridge, MA, USA.
Moji AghajaniDepartment of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
Clara AllozaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain.
Dag AlnæsNORMENT Centre, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-7361-5418
Eric ArtigesINSERM U1299 Trajectoires Développementales en Psychiatrie, Ecole Normale Supérieure Paris-Saclay, Université Paris Saclay, Université Paris Cité, CNRS UMR 9010; Centre Borelli, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0003-4461-7646
Rosa Ayesa-ArriolaValdecilla Biomedical Research Institute (IDIVAL), Marqués de Valdecilla University Hospital (HUMV), School of Medicine, University of Cantabria, Santander, Spain.
Gareth J BarkerDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-5214-7421
Mark E BastinLothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Elisabet BlokDepartment of Child and Adolescent Psychiatry/Psychology, Sophia Children's Hospital, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
Erlend BøenPsychosomatic and CL Psychiatry, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0002-9546-2763
Isabella A BreukelaarBrain Dynamics Centre, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW, Australia.ORCID http://orcid.org/0000-0002-6241-5274
Joanna K BrightImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Elizabeth E L BuimerDepartment of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-8143-3160
Robin BülowInstitute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-1884-5784
Dara M CannonCentre for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.ORCID http://orcid.org/0000-0001-7378-3411
Simone CiufoliniDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Nicolas A CrossleyDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Christienne G DamatacDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-9495-5243
Paola DazzanDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-8427-3617
Casper L de MolDepartment of Neurology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
Sonja M C de ZwarteDepartment of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
Sylvane DesrivièresSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-9120-7060
Covadonga M Díaz-CanejaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain.ORCID http://orcid.org/0000-0001-8538-3175
Nhat Trung DoanNORMENT Centre, University of Oslo, Oslo, Norway.
Katharina DohmInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Juliane H FröhnerSection of Systems Neuroscience, Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0002-8493-6396
Janik GoltermannInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0003-3087-1002
Antoine GrigisUniversité Paris-Saclay, CEA, Neurospin, Gif-sur-Yvette, France.
Dominik GrotegerdInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Laura K M HanDepartment of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-9647-3723
Mathew A HarrisLothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-1135-4141
Catharina A HartmanUniversity of Groningen, University Medical Center Groningen, Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), Groningen, The Netherlands.
Sarah J HeanyDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Walter HeindelClinic for Radiology, University Hospital Münster, Münster, Germany.
Dirk J HeslenfeldDepartments of Experimental and Clinical Psychology, Amsterdam, The Netherlands.
Sarah HohmannDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
Bernd IttermannPhysikalisch-Technische Bundesanstalt, Berlin, Germany.
Philip R JansenDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-1550-2444
Joost JanssenDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain.
Tianye JiaCentre for Population Neuroscience and Precision Medicine (PONS), Institute of Science and Technology for Brain-Inspired Intelligence and MoE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0001-5399-2953
Jiyang JiangCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-2147-6302
Christiane JockwitzInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
Temmuz KaraliDepartment of Psychiatry and Psychotherapy, University Hospital LMU, Munich, Germany.
Daniel KeeserDepartment of Psychiatry and Psychotherapy, University Hospital LMU, Munich, Germany.ORCID http://orcid.org/0000-0002-0244-1024
Martijn G J C KoevoetsDepartment of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-8347-0379
Rhoshel K LenrootSchool of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
Berend MalchowDepartment of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
René C W MandlDepartment of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
Vicente MedelDepartment of Psychiatry, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID http://orcid.org/0000-0003-2443-8683
Susanne MeinertInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Catherine A MorganSchool of Psychology and Centre for Brain Research, University of Auckland, Auckland, New Zealand.ORCID http://orcid.org/0000-0002-5837-8861
Thomas W MühleisenInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.ORCID http://orcid.org/0000-0002-6057-5952
Leila NabulsiCentre for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.ORCID http://orcid.org/0000-0001-9448-7769
Nils OpelInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Víctor Ortiz-García de la FozValdecilla Biomedical Research Institute (IDIVAL), Marqués de Valdecilla University Hospital (HUMV), School of Medicine, University of Cantabria, Santander, Spain.
Bronwyn J OversNeuroscience Research Australia, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-7138-5556
Marie-Laure Paillère MartinotINSERM U1299 Trajectoires Développementales en Psychiatrie, Ecole Normale Supérieure Paris-Saclay, Université Paris Saclay, Université Paris Cité, CNRS UMR 9010; Centre Borelli, Gif-sur-Yvette, France.
Ronny RedlichInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Tiago Reis MarquesDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-0602-7661
Jonathan ReppleInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Gloria RobertsSchool of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
Gennady V RoshchupkinDepartment of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-3403-2313
Nikita SetiamanDepartment of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-9951-0665
Elena ShumskayaDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Frederike SteinDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Gustavo SudreSocial and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, MD, USA.
Shun TakahashiDepartment of Psychiatry and Psychotherapy, University Hospital LMU, Munich, Germany.
Anbupalam ThalamuthuCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, NSW, Australia.
Diana Tordesillas-GutiérrezDepartment of Radiology, IDIVAL, Marqués de Valdecilla University Hospital, Santander, Spain.ORCID http://orcid.org/0000-0003-1458-3932
Aad van der LugtDepartment of Radiology & Nuclear Medicine, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Neeltje E M van HarenDepartment of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
Joanna M WardlawLothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-9812-6642
Wei WenCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-2753-3870
Henk-Jan WestenengDepartment of Neurology, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
Katharina WittfeldGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-4383-5043
Alyssa H ZhuImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Andre ZugmanLaboratory of Integrative Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Nicola J ArmstrongMathematics and Statistics, Curtin University, Perth, WA, Australia.
Gaia BonfiglioDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands.
Janita BraltenDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Shareefa DalvieDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0003-2333-4823
Gail DaviesLothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-1120-7026
Marta Di FortiSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Linda DingImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Gary DonohoeCentre for Neuroimaging, Cognition and Genomics (NICOG), School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, Galway, Ireland.ORCID http://orcid.org/0000-0003-3037-7426
Andreas J ForstnerInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
Javier Gonzalez-PeñasDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain.
Joao P O F T GuimaraesDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Jouke-Jan HottengaNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-5668-2368
Maria J KnolDepartment of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-3597-1531
John B J KwokFaculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Stephanie Le HellardNORMENT Centre of Excellence, Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0002-8085-051X
Karen A MatherCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-4143-8941
Yuri MilaneschiDepartment of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-3697-6617
Derek W MorrisCentre for Neuroimaging, Cognition and Genomics (NICOG), School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, Galway, Ireland.ORCID http://orcid.org/0000-0002-3413-570X
Markus M NöthenInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-8770-2464
Sergi PapiolCIBERSAM, Biomedical Research Network on Mental Health Area, Santander, Spain.ORCID http://orcid.org/0000-0001-9366-8728
Marcella RietschelDepartment of Genetic Epidemiology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0002-5236-6149
Marcos L SantoroLaboratory of Integrative Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.ORCID http://orcid.org/0000-0001-5714-9509
Vidar M SteenNORMENT Centre of Excellence, Department of Clinical Science, University of Bergen, Bergen, Norway.
Jason L SteinDepartment of Genetics & UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-4829-0513
Fabian StreitDepartment of Genetic Epidemiology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0003-1080-4339
Rick M TankardMathematics and Statistics, Curtin University, Perth, WA, Australia.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-8309-094X
Dennis van 't EntNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-2001-1375
Dennis van der MeerNORMENT Centre, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-0466-386X
Kristel R van EijkDepartment of Neurology, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
Evangelos VassosSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0001-6363-0438
Javier Vázquez-BourgonValdecilla Biomedical Research Institute (IDIVAL), Marqués de Valdecilla University Hospital (HUMV), School of Medicine, University of Cantabria, Santander, Spain.ORCID http://orcid.org/0000-0002-5478-3376
Stephanie H WittDepartment of Genetic Epidemiology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0002-1571-1468
IMAGEN Consortium
Hieab H H AdamsDepartment of Radiology & Nuclear Medicine, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-3687-2508
Ingrid AgartzNORMENT Centre, University of Oslo, Oslo, Norway.
David AmesAcademic Unit for Psychiatry of Old Age, University of Melbourne, Parkville, VIC, Australia.
Katrin AmuntsInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.ORCID http://orcid.org/0000-0001-5828-0867
Ole A AndreassenNORMENT Centre, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-4461-3568
Celso ArangoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain.ORCID http://orcid.org/0000-0003-3382-4754
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0003-4595-1144
Bernhard T BauneDepartment of Psychiatry, University of Melbourne, Melbourne VIC, Australia.
Sintia I BelangeroLaboratory of Integrative Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.ORCID http://orcid.org/0000-0002-2419-4351
Arun L W BokdeDiscipline of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0003-0114-4914
Dorret I BoomsmaNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7099-7972
Rodrigo A BressanLaboratory of Integrative Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Henry BrodatyCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0001-9487-6617
Jan K BuitelaarDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-8288-7757
Wiepke CahnDepartment of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
Svenja CaspersInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
Sven CichonInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.ORCID http://orcid.org/0000-0002-9475-086X
Benedicto Crespo-FacorroCIBERSAM, Biomedical Research Network on Mental Health Area, Santander, Spain.
Simon R CoxLothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-4036-3642
Udo DannlowskiInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-0623-3759
Torbjørn ElvsåshagenNORMENT Centre, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0001-9991-1610
Thomas EspesethDepartment of Psychology, University of Oslo, Oslo, Norway.
Peter G FalkaiDepartment of Psychiatry and Psychotherapy, University Hospital LMU, Munich, Germany.
Simon E FisherDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-3132-1996
Herta FlorDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Janice M FullertonNeuroscience Research Australia, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-4014-4490
Hugh GaravanDepartment of Psychiatry, University of Vermont, Burlington, VT, USA.ORCID http://orcid.org/0000-0002-8939-1014
Penny A GowlandSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0002-4900-4817
Hans J GrabeGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-3684-4208
Tim HahnInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0001-6541-3795
Andreas HeinzCharité Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-5405-9065
Manon HillegersDepartment of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0003-4877-282X
Jacqueline HoareDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0002-6963-3557
Pieter J HoekstraUniversity of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry & Accare Child Study Center, Groningen, The Netherlands.
Mohammad A IkramDepartment of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Andrea P JackowskiLaboratory of Integrative Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.ORCID http://orcid.org/0000-0001-8842-5406
Andreas JansenDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Erik G JönssonNORMENT Centre, University of Oslo, Oslo, Norway.
Rene S KahnDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-5909-8004
Tilo KircherDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Mayuresh S KorgaonkarBrain Dynamics Centre, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW, Australia.ORCID http://orcid.org/0000-0002-1339-2221
Axel KrugDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-0564-2497
Herve LemaitreGroupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, CNRS UMR 5293, Université de Bordeaux, Centre Broca Nouvelle-Aquitaine, Bordeaux, France.
Ulrik F MaltUnit for Psychosomatic Medicine and C-L Psychiatry, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-9881-2511
Jean-Luc MartinotINSERM U1299 Trajectoires Développementales en Psychiatrie, Ecole Normale Supérieure Paris-Saclay, Université Paris Saclay, Université Paris Cité, CNRS UMR 9010; Centre Borelli, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0002-0136-0388
Colm McDonaldCentre for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.ORCID http://orcid.org/0000-0003-1661-5192
Philip B MitchellSchool of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
Ryan L MuetzelDepartment of Child and Adolescent Psychiatry/Psychology, Sophia Children's Hospital, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-3215-1287
Robin M MurrayDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-0829-0519
Frauke NeesDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0002-7796-8234
Igor NenadićDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Jaap OosterlaanEmma Children's Hospital, Amsterdam UMC, University of Amsterdam, Emma Neuroscience Group, Department of Pediatrics, Amsterdam Reproduction & Development, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-0218-5630
Roel A OphoffCenter for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-8287-6457
Pedro M PanLaboratory of Integrative Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Brenda W J H PenninxDepartment of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
Luise PoustkaDepartment of Child and Adolescent Psychiatry, University Medical Center Goettingen, Göttingen, Germany.
Perminder S SachdevCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-9595-3220
Giovanni A SalumNational Institute of Developmental Psychiatry for Children and Adolescents (INPD), CNPq, São Paulo, Brazil.
Peter R SchofieldNeuroscience Research Australia, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-2967-9662
Gunter SchumannCenter for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology for Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-7740-6469
Philip ShawSocial and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-1313-2526
Kang SimWest Region, Institute of Mental Health, Singapore, Singapore.ORCID http://orcid.org/0000-0003-3209-9626
Michael N SmolkaDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0001-5398-5569
Dan J SteinSAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0001-7218-7810
Julian N TrollorCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-7685-2977
Leonard H van den BergDepartment of Neurology, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
Jan H VeldinkDepartment of Neurology, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-5572-9657
Henrik WalterCharité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute for Health, Berlin, Germany.ORCID http://orcid.org/0000-0002-9403-6121
Lars T WestlyeNORMENT Centre, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-8644-956X
Robert WhelanTrinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Tonya WhiteDepartment of Child and Adolescent Psychiatry/Psychology, Sophia Children's Hospital, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
Margaret J WrightQueensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0001-7133-4970
Sarah E MedlandQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-1382-380X
Barbara Franke *Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-4375-6572
Paul M Thompson *Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Hilleke E Hulshoff Pol *Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands. h.e.hulshoffpol@uu.nl.ORCID http://orcid.org/0000-0002-2038-5281
Utrecht University · NLUNSW Sydney · AUErasmus MC · NLKing's College London · GBRadboud University Nijmegen · NLUniversity of Münster · DEHeidelberg University · DENational Council for Scientific and Technological Development · BROslo University Hospital · NOUniversity of Southern California · USForschungszentrum Jülich · DEHospital General Universitario Gregorio Marañón · ESNHS Lothian · GBOllscoil na Gaillimhe – University of Galway · IEUniversitätsmedizin Greifswald · DEUniversity of Oslo · NOAmsterdam Neuroscience · NLLMU Klinikum · DEPhilipps University of Marburg · DEÉcole Normale Supérieure Paris-Saclay · FR

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7M
ABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5M
Adolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5M
ABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7M
Prospective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2M
ABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7M
The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
ABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9M
FIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8M
ABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3M
The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
Chief Scientist OfficeDepartment of HealthEPA EP-C-15-001Medical Research Council G0701120Medical Research Council G1001245Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MR/M013111/1Medical Research Council MR/N000390/1Medical Research Council MR/N027558/1Medical Research Council MR/R00465X/1Medical Research Council MR/R024065/1Medical Research Council MR/S003444/1Medical Research Council MR/S020306/1MRF_ C0439MRF_ MRF-058-0004-RG-DESRIMRF_ MRF-058-0009-RG-DESR-C0759NIA NIH HHS P01 AG055367NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG054002NIA NIH HHS R01 AG058854NIA NIH HHS R01 AG059874NIA NIH HHS R01 AG060470NIA NIH HHS R01 AG064955NIA NIH HHS R01 AG076838NIA NIH HHS R56 AG037985NIA NIH HHS R56 AG058854NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG068057NIBIB NIH HHS P41 EB015922NIBIB NIH HHS U54 EB020403NICHD NIH HHS R01 HD074051NICHD NIH HHS U54 HD087101NIDA NIH HHS R01 DA047119NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U01 DA050987NIDA NIH HHS U01 DA050988NIDA NIH HHS U01 DA050989NIDA NIH HHS U01 DA051016NIDA NIH HHS U01 DA051018NIDA NIH HHS U01 DA051037NIDA NIH HHS U01 DA051038NIDA NIH HHS U01 DA051039NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147NIMH NIH HHS K99 MH116115NIMH NIH HHS R01 MH062873NIMH NIH HHS R01 MH085772NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH117601NIMH NIH HHS R01 MH118349NIMH NIH HHS R01 MH120125NIMH NIH HHS R01 MH129832NIMH NIH HHS R21 MH107327NIMH NIH HHS RC2 MH089995Wellcome TrustWellcome Trust 221890/Z/20/Z
6 · The paper itself

Abstract

Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging.

Indexed as

Genome-Wide Association StudyLongevityAgingBrainHumansMagnetic Resonance Imaging

Identifiers

PMID35383335
PMCPMC10040206
OpenAlexW4223623530

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