ArticleNature neuroscience2022
Altered adult neurogenesis and gliogenesis in patients with mesial temporal lobe epilepsy.
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Article in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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60citing papers in PubMed, 1 pooled it
14.9field-weighted citation impact, top 1% of its field
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Hippocampal neurogenesis in adult primates: a systematic review.Molecular psychiatry · 2025Pooled it
- NGF-Hydrogel Ameliorates Aberrant Adult Hippocampal Neurogenesis and Improves Hippocampal Remodeling After Epilepsy.Current issues in molecular biology · 2026Article
- Cross-species transcriptomic analysis of rodent model fidelity to human mesial temporal lobe epilepsy.Nature communications · 2026Article
- Duration-dependent hippocampal structural changes in focal epilepsy: multicenter neuroimaging evidence.Journal of translational medicine · 2026Article
- Harnessing the stem cell potential in the human hippocampus to limit cognitive aging.PLoS biology · 2026Article
- Reblastatin as a neuroprotective agent in temporal lobe epilepsy and excitotoxic conditions of Alzheimer's disease and Parkinson's disease.Acta pharmaceutica Sinica. B · 2026Article
- Review
- Spatial transcriptomics in epilepsy research: Early successes, opportunities, and challenges.Epilepsia · 2026Article
- Aberrantly integrated adult-born immature neurons disrupt brain-wide networks during spatial memory processing.Molecular psychiatry · 2026Article
- Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease.Epilepsia · 2026Article
- Glucocorticoid-Induced Tumor Necrosis Factor Receptor Ligand: Correlation and Therapeutic Potential for Cognitive Impairment in Temporal Lobe Epilepsy.Clinical and translational science · 2026Article
- Soft sonocapacitor with topologically integrated piezodielectric nanospheres enables wireless epidural closed-loop neuromodulation.Nature communications · 2026Article
- Permethrin induces epileptic susceptibility via activation of NaCommunications biology · 2025Article
- Advances in gene therapy for Lafora disease: Intravenous recombinant adeno-associated virus-mediated delivery of EPM2A and EPM2B genes.Clinical and translational medicine · 2025Article
- Dual inhibition of IRAK1/TAK1 signaling in astrocytes reduces accelerated mortality in human APOE4 knock-in APPswe/PSEN1dE9/P301S-Tau triple transgenic mouse model.Journal of neuroinflammation · 2025Article
- Adult hippocampal neurogenesis: New avenues for treatment of brain disorders.Stem cell reports · 2025Review
- Cross-species analysis of adult hippocampal neurogenesis reveals human-specific gene expression but convergent biological processes.Nature neuroscience · 2025Article
- The Impact of Small Molecule on the Astrocyte's Viability Derived From Epileptic Brain Tissues.Basic and clinical neuroscience · 2025Article
- The Role of Neuroinflammation and Network Anomalies in Drug-Resistant Epilepsy.Neuroscience bulletin · 2025Review
- Neural stem and progenitor cells support and protect adult hippocampal function via vascular endothelial growth factor secretion.Molecular psychiatry · 2025Article
Corrections and comments
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Authors and funding
23 authors at 3 institutions in 2 countries.
Aswathy AmmothumkandyDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Kristine RavinaNeurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Victoria WolseleyDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Alexandria N TarttDivision of Molecular Imaging and Neuropathology, NYS Psychiatric Institute, New York, NY, USA.
Pen-Ning YuDepartment of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Luis CoronaDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Naibo ZhangDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
George NuneNeurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Laura KalayjianDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
J John MannDivision of Molecular Imaging and Neuropathology, NYS Psychiatric Institute, New York, NY, USA.ORCID http://orcid.org/0000-0002-0265-6586
Gorazd B RosoklijaDivision of Molecular Imaging and Neuropathology, NYS Psychiatric Institute, New York, NY, USA.
Victoria ArangoDivision of Molecular Imaging and Neuropathology, NYS Psychiatric Institute, New York, NY, USA.
Andrew J DworkDivision of Molecular Imaging and Neuropathology, NYS Psychiatric Institute, New York, NY, USA.
Brian LeeNeurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
J A D SmithNeurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-3209-5804
Dong SongDepartment of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6179-1120
Theodore W BergerDepartment of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Christianne HeckNeurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Robert H ChowDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Maura BoldriniDivision of Molecular Imaging and Neuropathology, NYS Psychiatric Institute, New York, NY, USA.ORCID http://orcid.org/0000-0003-3574-7641
Charles Y LiuNeurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-6423-8577
Jonathan J RussinNeurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Michael A BonaguidiDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. mbonagui@usc.edu.ORCID http://orcid.org/0000-0002-9295-4762
University of Southern California · USNew York Psychoanalytic Society and Institute · USMacedonian Academy of Sciences and Arts · MK
Funding
Suicidal Behavior: Aggression Subtypes, Childhood Adversity and Stress ResponseP50MH090964 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MANN, JOSEPH JOHN · 2013 to 2022
$23.6MEvaluation of Cellular Heterogeneity Using Patchclamp and RNA-Seq of Single CellsU01MH098937 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHOW, ROBERT HSIU-PING, KNOWLES, JAMES A · 2012 to 2016
$8.6MPOSTMORTEM NEUROCHEMICAL STUDIES IN SUICIDER01MH040210 · NIMH · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI UNDERWOOD, MARK D · 1985 to 2016
$7.0MEffect of Major Depression and antidepressants on human neurogenesisR01MH083862 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BOLDRINI, MAURA, HEN, RENE · 2009 to 2018
$5.4MNew technologies to identify molecular regulators of the human hippocampus neurogenic niche in healthy aging and Alzheimer's DiseaseR01AG076949 · NIA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Maura Boldrini Dupont · 2022 to 2026
$4.4MGolgi Studies of SchizophreniaR01MH064168 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI DWORK, ANDREW J · 2001 to 2013
$4.3MPRIMING THE PUMP: TRAINING PHYSICIAN-SCIENTISTS IN TRANSLATIONAL PSYCHIATRYR25MH086466 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Melissa Arbuckle, Eduardo David Leonardo · 2009 to 2026
$4.3MBuilding Schizophrenia Research in MacedoniaR01MH098786 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DWORK, ANDREW J, ROSOKLIJA, GORAZD B. · 2012 to 2016
$2.2MThe Neuropathology of SUDEP : The central autonomic network, Serotonin and adenosineU01NS090415 · NINDS · UNIVERSITY COLLEGE LONDON · PI BOLDRINI, MAURA, DEVINSKY, ORRIN · 2014 to 2018
$2.0MMechanisms Underlying Neural Stem Cell Heterogeneity in the Adult HippocampusR00NS080913 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BONAGUIDI, MICHAEL · 2015 to 2017
$747kMechanisms Underlying Adult Neural Stem Cell HomeostasisR56AG064077 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BONAGUIDI, MICHAEL · 2019 to 2019
$611kTrophic factors and regulation of hippocampal neuroplasticity in the human brainR21MH094888 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BOLDRINI, MAURA · 2011 to 2012
$454kNIAID NIH HHS R21 AI164769NIA NIH HHS R01 AG076949NIA NIH HHS R56 AG064077NIMH NIH HHS P50 MH090964NIMH NIH HHS R01 MH040210NIMH NIH HHS R01 MH064168NIMH NIH HHS R01 MH083862NIMH NIH HHS R01 MH098786NIMH NIH HHS R21 MH094888NIMH NIH HHS R25 MH086466NIMH NIH HHS U01 MH098937NINDS NIH HHS L40 NS089013NINDS NIH HHS R00 NS080913NINDS NIH HHS U01 NS090415
Abstract
The hippocampus is the most common seizure focus in people. In the hippocampus, aberrant neurogenesis plays a critical role in the initiation and progression of epilepsy in rodent models, but it is unknown whether this also holds true in humans. To address this question, we used immunofluorescence on control healthy hippocampus and surgical resections from mesial temporal lobe epilepsy (MTLE), plus neural stem-cell cultures and multi-electrode recordings of ex vivo hippocampal slices. We found that a longer duration of epilepsy is associated with a sharp decline in neuronal production and persistent numbers in astrogenesis. Further, immature neurons in MTLE are mostly inactive, and are not observed in cases with local epileptiform-like activity. However, immature astroglia are present in every MTLE case and their location and activity are dependent on epileptiform-like activity. Immature astroglia, rather than newborn neurons, therefore represent a potential target to continually modulate adult human neuronal hyperactivity.
Indexed as
EpilepsyEpilepsy, Temporal LobeHippocampusHumansMagnetic Resonance ImagingNeurogenesisSeizures
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