Evidence map›Paper›PMID 35383319›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2022

In vivo imaging translocator protein (TSPO) in autism spectrum disorder.

Dominic Simpson, Avideh Gharehgazlou, Tania Da Silva, Charlotte Labrie-Cleary, Alan A Wilson, Jeffrey H Meyer, Romina Mizrahi, Pablo M Rusjan

Open access · bronzeAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Influence of Translocator Protein (Life (Basel, Switzerland) · 2026
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  7. In vivo translocator protein in females with autism spectrum disorder: a pilot study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Dominic Simpson *Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
Avideh Gharehgazlou *Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.
Tania Da SilvaTemerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Charlotte Labrie-ClearyDouglas Mental Health University Institute, Montreal, QC, Canada.
Alan A WilsonResearch Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Jeffrey H MeyerDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-4684-5052
Romina MizrahiDouglas Mental Health University Institute, Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-6667-7928
Pablo M RusjanDouglas Mental Health University Institute, Montreal, QC, Canada. pablo.rusjan@mcgill.ca.ORCID http://orcid.org/0000-0003-0075-2918
Centre for Addiction and Mental Health · CADouglas Mental Health University Institute · CAUniversity of Toronto · CA

Funding

CIHR MOP-142376
6 · The paper itself

Abstract

Converging evidence points to the significant involvement of the immune system in autism spectrum disorders (ASD). Positron emission tomography (PET) can quantify translocator protein 18 kDa (TSPO), a marker with increased expression mainly in microglia and, to some extent astroglia during neuropsychiatric diseases with inflammation. This preliminary analysis explored, for the first time, whether TSPO binding was altered in male and female participants with ASD in vivo using full kinetic quantification. Thirteen individuals with ASD (IQ > 70 [n = 12], IQ = 62 [n = 1]), 5 F, 25 ± 5 years) were scanned with [

Indexed as

Autism Spectrum DisorderMajor Depressive DisorderAdultAnilidesBrainFemaleHumansMalePositron-Emission TomographyPyridinesReceptors, GABAYoung AdultAnilidesPyridinesReceptors, GABATSPO protein, human

Identifiers

PMID35383319
PMCPMC9117200
OpenAlexW4226302559

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.