Evidence map›Paper›PMID 35383262›Full record

ArticlePediatric research2022

Neonatal outcomes of twins <29 weeks gestation of mothers with hypertensive disorders of pregnancy.

Katherine Yurkiw, Belal Alshaikh, Shabih U Hasan, Deepak Louis, Julie Emberley, Martine Claveau, Marc Beltempo, Kamran Yusuf, Canadian Neonatal Network Investigators

Abstract read
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Article in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Katherine YurkiwPediatrics, University of Calgary, Calgary, AB, Canada.
Belal AlshaikhPediatrics, University of Calgary, Calgary, AB, Canada.
Shabih U HasanPediatrics, University of Calgary, Calgary, AB, Canada.
Deepak LouisPediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.
Julie EmberleyPediatrics, Memorial University, St. John's Newfoundland and Labrador, St. John's, NF, Canada.
Martine ClaveauPediatrics, McGill University, Montreal, QC, Canada.
Marc BeltempoPediatrics, McGill University, Montreal, QC, Canada.
Kamran YusufPediatrics, University of Calgary, Calgary, AB, Canada. kyusuf@ucalgary.ca.ORCID 0000-0001-5270-5326
Canadian Neonatal Network Investigators
University of Calgary · CAMcGill University · CAMemorial University of Newfoundland · CAUniversity of Manitoba · CA

Funding

CIHR APR-126340CIHR CTP 87518
6 · The paper itself

Abstract

backgroundHypertensive disorders of pregnancy (HDP) are associated with dysfunctional placentation and are a major cause of maternal and neonatal morbidity and mortality. Twin pregnancies have a larger placental mass and are a risk factor for HDP. The effect of HDP on neonatal outcomes in twin pregnancies is unknown.

methodsRetrospective cohort study using the Canadian Neonatal Network database from 2010-2018 of twin infants <29 weeks gestation born to mothers with HDP and normotensive pregnancies. Using multivariable models, we determined adjusted odds ratios (AORs) and 95% confidence intervals (CI) for mortality, bronchopulmonary dysplasia, severe neurologic injury, severe retinopathy of prematurity (ROP), necrotizing enterocolitis, and nosocomial infection in twin infants of mothers with HDP compared to twin infants of normotensive mothers.

resultsOf the 2414 eligible twin infants <29 weeks gestational age, 164 (6.8%) were born to mothers with HDP and had higher odds of severe ROP (AOR 2.48, 95% CI 1.34-4.59). Preterm twin infants born to mothers with HDP also had higher odds of mortality (AOR 2.02, 95% CI 1.23-3.32). There was no difference in other outcomes.

conclusionPreterm twin infants <29 weeks gestation of HDP mothers have higher odds of severe ROP and mortality. IMPACT: Hypertensive disorders of pregnancy, associated with placental dysfunction, are a major cause of maternal and neonatal morbidity and mortality. Twin pregnancy, associated with a larger placental mass, is a risk factor for hypertensive disorders of pregnancy. The effect of hypertensive disorders of pregnancy on outcomes of preterm twins is unknown. Preterm twins of mothers with hypertensive disorders of pregnancy are at higher risk of severe retinopathy of prematurity and mortality. Our data can be used to counsel parents and identify infants at higher risk of severe retinopathy of prematurity and mortality.

Indexed as

Hypertension, Pregnancy-InducedPre-EclampsiaRetinopathy of PrematurityCanadaFemaleGestational AgeHumansInfantInfant, NewbornPlacentaPregnancyPregnancy, TwinRetrospective Studies

Identifiers

PMID35383262
OpenAlexW4225769499

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.