ArticleNature communications2022
Ultraviolet optical horn antennas for label-free detection of single proteins.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Scalable production of monovalent streptavidin with high yield and purity.Scientific reports · 2026Article
- Mie Voids for Single-Molecule Fluorescence Enhancement in Wavelength-Scale Detection Volumes.Sensors (Basel, Switzerland) · 2025Article
- Nanocomposite-based PCR reactors to enhance thermal rate and fluorescence intensity in hand-held qPCR device.Journal of nanobiotechnology · 2025Article
- Angle-controlled strong and weak coupling in photon molecules.Scientific reports · 2025Article
- Dual-wavelength metalens enables Epi-fluorescence detection from single molecules.Nature communications · 2024Article
- Ultraviolet Resonant Nanogap Antennas with Rhodium Nanocube Dimers for Enhancing Protein Intrinsic Autofluorescence.ACS nano · 2023Article
- Dual-wavelength UV-visible metalens for multispectral photoacoustic microscopy: A simulation study.Photoacoustics · 2023Article
- Recent advances in quantum nanophotonics: plexcitonic and vibro-polaritonic strong coupling and its biomedical and chemical applications.Nanophotonics (Berlin, Germany) · 2023Review
- Research on a Fiber Optic Oxygen Sensor Based on All-Phase Fast Fourier Transform (apFFT) Phase Detection.Sensors (Basel, Switzerland) · 2022Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Single-molecule fluorescence techniques have revolutionized our ability to study proteins. However, the presence of a fluorescent label can alter the protein structure and/or modify its reaction with other species. To avoid the need for a fluorescent label, the intrinsic autofluorescence of proteins in the ultraviolet offers the benefits of fluorescence techniques without introducing the labelling drawbacks. Unfortunately, the low autofluorescence brightness of proteins has greatly challenged single molecule detection so far. Here we introduce optical horn antennas, a dedicated nanophotonic platform enabling the label-free detection of single proteins in the UV. This design combines fluorescence plasmonic enhancement, efficient collection up to 85° angle and background screening. We detect the UV autofluorescence from immobilized and diffusing single proteins, and monitor protein unfolding and dissociation upon denaturation. Optical horn antennas open up a unique and promising form of fluorescence spectroscopy to investigate single proteins in their native states in real time.
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