ReviewTranslational psychiatry2022
Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies.
Review in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Psychotropic medications and their interactions with subcortical brain volume in bipolar disorder: An ENIGMA mega-analysis.Molecular psychiatry · 2026Pooled it
- The effect of repetitive transcranial magnetic stimulation on immediate and long-term cognitive functions in Alzheimer's dementia and mild cognitive impairment: a meta-analysis.Journal of neuroengineering and rehabilitation · 2025Pooled it
- Parallel anterior cingulate cortex pathways underlie dissociable social and attentional outputs.Science advances · 2026Article
- Schizophrenia and bipolar disorder: a comparative analysis of genetic and brain network connectivity.Psychological medicine · 2026Article
- Exploring the Associations Between Affective and Non-Affective Cognitive Domains in Mood Disorders and Healthy Controls Using Network Analysis.Acta psychiatrica Scandinavica · 2026Article
- Distinct and common subcortical functional connectivity revealed across three major psychiatric disorders.Psychological medicine · 2026Article
- The anxious bipolar phenotype: clinical complexity and treatment response.International journal of bipolar disorders · 2026Article
- Identification of Brain Regions and Networks Critical to Poststroke Cognitive Impairment Through Lesion-symptom and Lesion Network Analyses.Translational stroke research · 2026Article
- Genetic and neuroanatomical correlates of bipolar disorder in high-risk youth.BMJ mental health · 2026Article
- The Anxious Bipolar Phenotype: Clinical Complexity and Treatment Resistance.Research square · 2026Article
- Altered regional homogeneity in Parkinson's disease with mild cognitive impairment: a resting-state fMRI study.Frontiers in psychology · 2026Article
- From brain to behavior: Psychological resilience mediates associations between whole-brain resting-state connectivity and NSSI.Dialogues in clinical neuroscience · 2025Article
- The application of amplitude of low-frequency fluctuations metrics in the diagnosis and prediction of treatment response as well as their associated genes and biological processes in patients with bipolar disorder.Translational psychiatry · 2025Article
- Parvalbumin and Somatostatin Neurons in the Thalamic Reticular Nucleus Modulate Visual Information Processing in V1 of Mouse.Neuroscience bulletin · 2025Article
- Investigating topological alterations in procedural memory network across neuropsychiatric disorders using rs-fMRI and graph theory.BMC neuroscience · 2025Article
- Bipolar disorder.Lancet (London, England) · 2025Review
- Neural and Behavioral Markers of Negative Symptoms and Cognitive Impairment in Patients with Psychosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cerebral Blood Flow and Mood in Adolescents With Bipolar Disorder.JAACAP open · 2025Article
- Neuropsychiatric symptoms cluster and fluctuate over time in behavioral variant frontotemporal dementia.Psychiatry and clinical neurosciences · 2025Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bipolar disorder (BD) is a complex psychiatric disorder characterized by dysfunctions in three domains including emotional processing, cognitive processing, and psychomotor dimensions. However, the neural underpinnings underlying these clinical profiles are not well understood. Based on the reported data, we hypothesized that (i) the core neuropathology in BD is damage in fronto-limbic network, which is associated with emotional dysfunction; (ii) changes in intrinsic brain network, such as sensorimotor network, salience network, default-mode network, central executive network are associated with impaired cognition function; and (iii) beyond the dopaminergic-driven basal ganglia-thalamo-cortical motor circuit modulated by other neurotransmitter systems, such as serotonin (subcortical-cortical modulation), the sensorimotor network and related motor function modulated by other non-motor networks such as the default-mode network are involved in psychomotor function. In this review, we propose a neurocircuit-based clinical characteristics and taxonomy to guide the treatment of BD. We draw on findings from neuropsychological and neuroimaging studies in BD and link variations in these clinical profiles to underlying neurocircuit dysfunctions. We consider pharmacological, psychotherapy, and neuromodulatory treatments that could target those specific neurocircuit dysfunctions in BD. Finally, it is suggested that the methods of testing the neurocircuit-based taxonomy and important limitations to this approach should be considered in future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.