Evidence map›Paper›PMID 35382909›Full record

ArticleInfection control and hospital epidemiology2022

Tuberculosis attributed to transmission within healthcare facilities, Botswana-The Kopanyo Study.

Jonathan P Smith, Chawangwa Modongo, Patrick K Moonan, Mbatshi Dima, Ogopotse Matsiri, Othusitse Fane, Eleanor S Click, Rosanna Boyd, Alyssa Finlay, Diya Surie and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection control and hospital epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Jonathan P SmithDepartment of Health Policy and Management, Yale University, New Haven, Connecticut.ORCID 0000-0002-6396-9164
Chawangwa ModongoBotswana-UPenn Partnership, University of Pennsylvania, Philadelphia, Pennsylvania.
Patrick K MoonanDivision of Global HIV and Tuberculosis, Centers for Disease Control and Prevention, Atlanta, Georgia.ORCID 0000-0002-3550-2065
Mbatshi DimaBotswana-UPenn Partnership, University of Pennsylvania, Philadelphia, Pennsylvania.
Ogopotse MatsiriBotswana-UPenn Partnership, University of Pennsylvania, Philadelphia, Pennsylvania.
Othusitse FaneBotswana-UPenn Partnership, University of Pennsylvania, Philadelphia, Pennsylvania.
Eleanor S ClickDivision of Global HIV and Tuberculosis, Centers for Disease Control and Prevention, Atlanta, Georgia.
Rosanna BoydDivision of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia.
Alyssa FinlayDivision of Global HIV and Tuberculosis, Centers for Disease Control and Prevention, Atlanta, Georgia.
Diya SurieDivision of Global HIV and Tuberculosis, Centers for Disease Control and Prevention, Atlanta, Georgia.ORCID 0000-0003-3931-1423
James L TobiasDepartment of Health Policy and Management, Yale University, New Haven, Connecticut.ORCID 0000-0001-8694-5002
Nicola M ZetolaDivision of Pulmonary and Critical Care Medicine, Augusta University, Georgia.
John E OeltmannDivision of Global HIV and Tuberculosis, Centers for Disease Control and Prevention, Atlanta, Georgia.ORCID 0000-0002-9728-8746
Centers for Disease Control and Prevention · USUniversity of Pennsylvania · USYale University · USAugusta University Health · US

Funding

Dynamics of TB and MDR TB transmission in areas with high HIV prevalenceR01AI097045 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ZETOLA, NICOLA MARIO · 2011 to 2015
$2.9M
NIAID NIH HHS R01 AI097045PEPFAR
6 · The paper itself

Abstract

objectiveHealthcare facilities are a well-known high-risk environment for transmission of

methodsWe combined data from a prospective, population-based molecular epidemiologic study with a universal electronic medical record (EMR) covering all healthcare facilities in Botswana to identify biologically plausible transmission events occurring at the healthcare facility. Patients with

resultsIn total, 1,881 participants had TB genotypic and EMR data suitable for analysis, resulting in 46,853 clinical encounters at 338 healthcare facilities. We identified 326 unique overlapping events involving 370 individual patients; 91 (5%) had biologic plausibility for transmission occurring at a healthcare facility. A sensitivity analysis estimated that 3%-8% of transmission may be attributable to healthcare facilities.

conclusionsAlthough effective interventions are critical in reducing individual risk for healthcare workers and patients at healthcare facilities, our findings suggest that development of targeted interventions aimed at community transmission may have a larger impact in reducing TB.

Indexed as

Mycobacterium tuberculosisTuberculosisBotswanaDelivery of Health CareHumansProspective Studieshealthcare facilitiesnosocomial transmissiontransmissionTuberculosis

Identifiers

PMID35382909
PMCPMC9535034
OpenAlexW4224298254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.