ArticleJournal of animal science and biotechnology2022
Zearalenone toxicosis on reproduction as estrogen receptor selective modulator and alleviation of zearalenone biodegradative agent in pregnant sows.
Article in Journal of animal science and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Review
- Viability of Commercially Available Rapid Test Strips for Mycotoxin Analysis Compared to Chromatographic Methods.Toxins · 2026Article
- Zearalenone Induces Gap Junction Damage in Ovine Ovarian Granulosa Cells by Upregulating GPR30 and Activating the Oxidative Stress-NLRP3 Inflammasome Axis.Biomolecules · 2026Article
- Zearalenone causes female reproductive lipotoxicity through the ERα-CD36/TLR4 signaling pathway.Communications biology · 2026Article
- A Study on the Spatial Distribution of Zearalenone and Deoxynivalenol in Oat Bran.Foods (Basel, Switzerland) · 2026Article
- Integrated Targeted and Untargeted Metabolomics Reveals the Toxic Mechanisms of Zearalenone in Goat Leydig Cells.Animals : an open access journal from MDPI · 2026Article
- Toxicity analysis of food contaminants based on network toxicology and molecular docking: A case study of Zearalenone.PloS one · 2026Article
- First gas chromatography-mass spectrometry (GC-MS) method for the detection and quantification of 11 trichothecenes and zearalenone in wheat plant-based beverages.Food chemistry: X · 2026Article
- Multiple Mycotoxin Contamination in Livestock Feed: Implications for Animal Health, Productivity, and Food Safety.Toxins · 2025Review
- Contamination of aflatoxin BJournal of animal science and biotechnology · 2025Article
- Zearalenone Exposure Damages Skeletal Muscle Through Oxidative Stress and Is Alleviated by Glutathione, Nicotinamide Mononucleotide, and Melatonin.Antioxidants (Basel, Switzerland) · 2025Article
- Review
- Effect of zearalenone in sugar beet products on zootechnical and reproductive performance and lesions of sows and piglets.Mycotoxin research · 2025Article
- Reproductive Toxicity of Zearalenone and Its Molecular Mechanisms: A Review.Molecules (Basel, Switzerland) · 2025Review
- Sow reproductive disorders: a key issue affecting the pig industry.Frontiers in veterinary science · 2025Review
- Zearalenone causes ovarian damage and abnormal estradiol secretion in meat rabbits by inducing oxidative stress and inflammatory responses.Frontiers in veterinary science · 2025Article
- Mycotoxin Biodegradation byToxins · 2024Review
- Chronic exposure to Zearalenone leads to endometrial hyperplasia in CD-1 mice by altering the inflammatory markers.Toxicology research · 2024Article
- Effects of a Multi-Component Mycotoxin-Detoxifying Agent on Oxidative Stress, Health and Performance of Sows.Toxins · 2023Article
- Relevance of Zearalenone and its modified forms in bakery products.Mycotoxin research · 2023Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundZearalenone (ZEA) is a resorcylic acid lactone derivative derived from various Fusarium species that are widely found in food and feeds. The molecular structure of ZEA resembles that of the mammalian hormone 17β-oestradiol, thus zearalenone and its metabolites are known to compete with endogenous hormones for estrogen receptors binding sites and to activate transcription of oestrogen-responsive genes. However, the effect of long-term low-dose ZEA exposure on the reproductive response to Bacillus subtilis ANSB01G culture for first-parity gilts has not yet been investigated. This study was conducted to investigate the toxic effects of ZEA as an estrogen receptor selective modulator and the alleviating effects of Bacillus subtilis ANSB01G cultures as ZEA biodegraders in pregnant sows during their first parity.
resultsA total of 80 first-parity gilts (Yorkshire × Landrace) were randomly assigned to four dietary treatments during gestation: CO (positive control); MO (negative control, 246 μg ZEA/kg diet); COA (CO + B. subtilis ANSB01G culture with 2 × 10
conclusionsCollectively, our study investigated the effects of feeding low-dose ZEA on reproduction in pregnant sows during their first parity. Feeding low-dose ZEA could modulate estrogen receptor-α and -β concentrations in specific organs, cause disturbance of reproductive hormones and vulva swelling, and damage organ histopathology and up-regulate apoptosis in sow models. Diet with Bacillus subtilis ANSB01G alleviated negative effects of the ZEA on gilts to some extent.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.