Evidence map›Paper›PMID 35382850›Full record

ArticleJournal of translational medicine2022

Propranolol as therapy for cerebral cavernous malformations: a cautionary note.

Robert Shenkar, Thomas Moore, Christian Benavides, Rhonda Lightle, Matthew R Detter, Nicholas Hobson, Romuald Girard, Dorothy DeBiasse, Mary Patrucco, Carol Gallione and 3 more

Open access · goldAbstract readLetter
In one paragraph

Article in Journal of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Robert ShenkarDepartment of Neurological Surgery, University of Chicago Medicine and Biological Sciences, 5841 S. Maryland, MC 3026, Chicago, IL, 60637, USA.ORCID 0000-0002-1300-6845
Thomas MooreDepartment of Neurological Surgery, University of Chicago Medicine and Biological Sciences, 5841 S. Maryland, MC 3026, Chicago, IL, 60637, USA.
Christian BenavidesDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
Rhonda LightleDepartment of Neurological Surgery, University of Chicago Medicine and Biological Sciences, 5841 S. Maryland, MC 3026, Chicago, IL, 60637, USA.
Matthew R DetterDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
Nicholas HobsonDepartment of Neurological Surgery, University of Chicago Medicine and Biological Sciences, 5841 S. Maryland, MC 3026, Chicago, IL, 60637, USA.
Romuald GirardDepartment of Neurological Surgery, University of Chicago Medicine and Biological Sciences, 5841 S. Maryland, MC 3026, Chicago, IL, 60637, USA.
Dorothy DeBiasseDepartment of Neurological Surgery, University of Chicago Medicine and Biological Sciences, 5841 S. Maryland, MC 3026, Chicago, IL, 60637, USA.
Mary PatruccoDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
Carol GallioneDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
Joseph M ZabramskiDepartment of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ, USA.
Douglas A Marchuk *Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
Issam A Awad *Department of Neurological Surgery, University of Chicago Medicine and Biological Sciences, 5841 S. Maryland, MC 3026, Chicago, IL, 60637, USA. iawad@uchicago.edu.
University of Chicago · USDuke University · USBarrow Neurological Institute · US

Funding

Somatic mutation(s) and cellular changes in CCM pathogenesisP01NS092521 · NINDS · DUKE UNIVERSITY · PI AWAD, ISSAM A · 2015 to 2024
$12.9M
Investigating the Molecular Pathways of Cerebral Cavernous Malformation MaturationF30HL140871 · NHLBI · DUKE UNIVERSITY · PI DETTER, MATTHEW ROBERT · 2018 to 2021
$91k
NHLBI NIH HHS F30 HL140871NIH HHS F30 HL140871NINDS NIH HHS P01 NS09252NINDS NIH HHS P01 NS092521
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Brain NeoplasmsHemangioma, Cavernous, Central Nervous SystemHumansMagnetic Resonance ImagingPropranololPropranolol

Identifiers

PMID35382850
PMCPMC8981698
OpenAlexW4223607723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.