ArticleBMC public health2022
Trends of notification rates and treatment outcomes of tuberculosis cases with and without HIV co-infection in eight rural districts of Uganda (2015 - 2019).
Article in BMC public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 18 citations in OpenAlex.
- The treatment success rate and associated factors among pulmonary bacteriologically confirmed and pulmonary clinically diagnosed drug susceptible TB coinfected with HIV in Teso Sub-Region, North-Eastern Uganda 2020-2021. a retrospective study.BMC infectious diseases · 2025Article
- Incidence and risk factors for tuberculosis at a rural HIV clinic in Uganda, 2012-2019; A retrospective cohort study.BMC public health · 2025Article
- Treatment adherence and its association with family support among pulmonary tuberculosis patients in Jinja, Eastern Uganda.Scientific reports · 2025Article
- Level of Family Support and Associated Factors Among Pulmonary Tuberculosis Patients in Eastern Uganda. A Baseline Cross-Sectional Study.Journal of multidisciplinary healthcare · 2025Article
- Five-year tuberculosis trends analysis in eight districts of Mwanza region, Tanzania; (2017-2021).BMC public health · 2024Article
- Review
- Article
- Burden of HIV and treatment outcomes among TB patients in rural Kenya: a 9-year longitudinal study.BMC infectious diseases · 2023Article
- Implementation of evidence-based multiple focus integrated intensified TB screening to end TB (EXIT-TB) package in East Africa: a qualitative study.BMC infectious diseases · 2023Article
- Treatment success and associated factors among drug-susceptible tuberculosis patients in Teso region, Uganda: a retrospective study.Therapeutic advances in infectious diseaseArticle
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10 authors at 2 institutions in 1 country.
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Abstract
backgroundThe End TB Strategy aims to reduce new tuberculosis (TB) cases by 90% and TB-related deaths by 95% between 2015 - 2035. We determined the trend of case notification rates (CNRs) and treatment outcomes of TB cases with and without HIV co-infection in rural Uganda to provide an interim evaluation of progress towards this global target in rural settings.
methodsWe extracted retrospective programmatic data on notified TB cases and treatment outcomes from 2015 - 2019 for eight districts in rural Uganda from the District Health Information System 2. We estimated CNRs as the number of TB cases per 100,000 population. Treatment success rate (TSR) was calculated as the sum of TB cure and treatment completion for each year. Trends were estimated using the Mann-Kendall test.
resultsA total of 11,804 TB cases, of which 5,811 (49.2%) were HIV co-infected, were notified. The overall TB CNR increased by 3.7-fold from 37.7 to 141.3 cases per 100,000 population in 2015 and 2019 respectively. The increment was observed among people with HIV (from 204.7 to 730.2 per 100,000, p = 0.028) and HIV-uninfected individuals (from 19.9 to 78.7 per 100,000, p = 0.028). There was a decline in the TSR among HIV-negative TB cases from 82.1% in 2015 to 63.9% in 2019 (p = 0.086). Conversely, there was an increase in the TSR among HIV co-infected TB cases (from 69.9% to 81.9%, p = 0.807).
conclusionThe CNR increased among people with and without HIV while the TSR reduced among HIV-negative TB cases. There is need to refocus programs to address barriers to treatment success among HIV-negative TB cases.
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