Evidence map›Paper›PMID 35382774›Full record

Observational studyBMC pediatrics2022

Antimicrobial treatment duration for uncomplicated bloodstream infections in critically ill children: a multicentre observational study.

Sandra Pong, Robert A Fowler, Srinivas Murthy, Jeffrey M Pernica, Elaine Gilfoyle, Patricia Fontela, Asgar H Rishu, Nicholas Mitsakakis, James S Hutchison, Michelle Science and 4 more

Open access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Sandra PongDepartment of Pharmacy, The Hospital for Sick Children, Toronto, ON, Canada. sandra.pong@sickkids.ca.
Robert A FowlerInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.
Srinivas MurthyDepartment of Pediatrics, Division of Critical Care, University of British Columbia, Vancouver, BC, Canada.
Jeffrey M PernicaDivision of Infectious Diseases, McMaster University, Hamilton, ON, Canada.
Elaine GilfoyleDepartment of Critical Care Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
Patricia FontelaDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.
Asgar H RishuInstitute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Nicholas MitsakakisChildren's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
James S HutchisonDepartment of Critical Care Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
Michelle ScienceDivision of Infectious Diseases, Department of Paediatric Medicine, The Hospital for Children, Toronto, ON, Canada.
Winnie SetoDepartment of Pharmacy, The Hospital for Sick Children, Toronto, ON, Canada.
Philippe JouvetPediatric Intensive Care Unit, Sainte-Justine Hospital University Center, Montreal, QC, Canada.
Nick DanemanDivision of Infectious Diseases, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Canadian Critical Care Trials Group
Hospital for Sick Children · CAHealth Sciences Centre · CABC Children's Hospital · CAMcGill University · CAMcMaster University · CAPublic Health Ontario · CAUniversité de Montréal · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBloodstream infections (BSIs) cause significant morbidity and mortality in critically ill children but treatment duration is understudied. We describe the durations of antimicrobial treatment that critically ill children receive and explore factors associated with treatment duration.

methodsWe conducted a retrospective observational cohort study in six pediatric intensive care units (PICUs) across Canada. Associations between treatment duration and patient-, infection- and pathogen-related characteristics were explored using multivariable regression analyses.

resultsAmong 187 critically ill children with BSIs, the median duration of antimicrobial treatment was 15 (IQR 11-25) days. Median treatment durations were longer than two weeks for all subjects with known sources of infection: catheter-related 16 (IQR 11-24), respiratory 15 (IQR 11-26), intra-abdominal 20 (IQR 14-26), skin/soft tissue 17 (IQR 15-33), urinary 17 (IQR 15-35), central nervous system 33 (IQR 15-46) and other sources 29.5 (IQR 15-55) days. When sources of infection were unclear, the median duration was 13 (IQR 10-16) days. Treatment durations varied widely within and across PICUs. In multivariable linear regression, longer treatment durations were associated with severity of illness (+ 0.4 days longer [95% confidence interval (CI), 0.1 to 0.7, p = 0.007] per unit increase in PRISM-IV) and central nervous system infection (+ 17 days [95% CI, 6.7 to 27.4], p = 0.001). Age and pathogen type were not associated with treatment duration.

conclusionsMost critically ill children with BSIs received at least two weeks of antimicrobial treatment. Further study is needed to determine whether shorter duration therapy would be effective for selected critically ill children.

Indexed as

Anti-Infective AgentsSepsisChildCritical IllnessDuration of TherapyHumansRetrospective StudiesAnti-Infective AgentsAntibacterial agentsBacteremiaCritical careCritical illnessDuration of therapyPediatric

Identifiers

PMID35382774
PMCPMC8981828
OpenAlexW4223437013

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.