Evidence map›Paper›PMID 35382753›Full record

ArticleBMC neurology2022

Caspr2 antibodies in herpes simplex encephalitis: an extension of the spectrum of virus induced autoimmunity? - A case report.

Klaus Berek, Ronny Beer, Astrid Grams, Raimund Helbok, Anna Lindner, Bettina Pfausler, Alois Schiefecker, Florian Deisenhammer, Harald Hegen

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Klaus BerekDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Ronny BeerDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Astrid GramsDepartment of Neuroradiology, Medical University of Innsbruck, Innsbruck, Austria.
Raimund HelbokDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Anna LindnerDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Bettina PfauslerDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Alois SchiefeckerDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Florian DeisenhammerDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Harald HegenDepartment of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria. harald.hegen@i-med.ac.at.ORCID http://orcid.org/0000-0002-2833-6337
Innsbruck Medical University · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPost herpes simplex virus (HSV) autoimmune encephalitis has been reported mainly in association with NMDA receptor antibodies, however, never with Caspr2 antibodies. CASE PRESENTATION: We report an 82-year old female patient with encephalitis who presented with aphasia, left temporo-mesial hyperintense lesion on MRI, epileptiform discharges on spot electroencephalography, cerebrospinal fluid (CSF) lymphocytic pleocytosis and who showed positive HSV polymerase chain reaction in CSF as well as antibodies against contactin-associated protein-like 2 (Caspr2).

conclusionThis is the first report of a patient with encephalitis who tested positive for HSV as well as for Caspr2 antibodies.

Indexed as

Encephalitis, Herpes SimplexHerpes SimplexAged, 80 and overAutoantibodiesAutoimmunityElectroencephalographyFemaleHumansMagnetic Resonance ImagingAutoantibodiesAutoimmunityCase reportCaspr2Herpes simplex virusVGKC

Identifiers

PMID35382753
PMCPMC8981196
OpenAlexW4223543124

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.