Local dynamics of pharmaceutical powder fluidization using high speed long distance microscopy and particle image velocimetry.

K Elserfy, S Cheng, H-K Chan, A Kourmatzis

Abstract read

In one paragraph

Article in Experimental thermal and fluid science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Effect of inflow conditioning for dry powder inhalers.International journal of pharmaceutics · 2021
Article

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

4 authors.

K ElserfySchool of Engineering, Macquarie University, NSW 2109, Australia.

S ChengSchool of Engineering, Macquarie University, NSW 2109, Australia.

H-K ChanAdvanced Drug Delivery Group, School of Pharmacy, University of Sydney, NSW 2006, Australia.

A KourmatzisSchool of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney, NSW 2006, Australia.

Funding

FDA HHS U01 FD006525

6 · The paper itself

Abstract

The local dynamics of fluidized pharmaceutical carrier powders in a turbulent channel flow was studied using particle image velocimetry (PIV) and High-speed, long-distance microscopy (HS-LDM). Four different lactose powders which have been used as a drug carrier in dry powder inhalers were used in this study. These powders have median powder particle diameters ranging between 61 and 121 μm. Air flow velocities ranging between 13.3 m/s and 66.7 m/s were examined. In addition, the effect of grid blockage ratio (ranging from ~25% to ~40% of the area of channel cross-section) was also investigated. Results show that the high-speed, long-distance microscopy (HS-LDM) technique was able to capture the mean velocity of the particles, and the results corresponded well with the PIV measurements. Results from the high-speed, long-distance microscopy (HS-LDM) method also demonstrate that the span of particle velocity closely follows that of the particle size distribution both for cohesive and non-cohesive powders. This study contributes towards an improved understanding of pharmaceutical carrier dynamics in turbulent channel flows and demonstrates how advanced image processing can be used to capture local particle dynamics.

Indexed as

Advanced imaging techniquesDry powder inhalersLactose carriersPharmaceutical carriersTwo-phase flow

Identifiers

PMID35382511

DOI10.1016/j.expthermflusci.2021.110367

PMCPMC8978356

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.