ArticleThe Egyptian journal of internal medicine2022
Diagnostic value of platelet indices in COVID 19 infection: a case-control study from a single tertiary care center.
Article in The Egyptian journal of internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Platelet Count and Platelet Indices as Predictive Markers of COVID-19 Mortality.Physiological research · 2026Article
- Clinical laboratory analytes and platelet-associated parameters as surrogate markers of subclinical inflammation in latent tuberculosis infection.Frontiers in immunology · 2025Article
- Comparison of Platelet Indices, Lymphocyte, and Systemic Inflammation Indices on Days 1 and 8 in Surviving and Non-Surviving COVID-19 Patients at Hasan Sadikin General Hospital, Bandung, Indonesia.Journal of blood medicine · 2025Article
- The Role of Platelet Parameters in Predicting the Disease Severity of COVID-19 Patients: A Hospital-Based Study.Cureus · 2024Article
- Assessment of the hematological profiles among COVID-19 patients during the first and second waves in Ethiopia: A multicenter retrospective cohort study.SAGE open medicine · 2024Article
- [Hematological indices associated with mortality in critically ill patients with COVID-19].Revista medica del Instituto Mexicano del Seguro Social · 2023Observational
- Nomogram to predict the incidence of delirium in elderly patients with non-severe SARS-CoV-2 infection.Frontiers in psychiatry · 2023Article
- Could platelet indices have diagnostic properties in children with COVID-19?Journal of clinical laboratory analysis · 2022Article
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3 authors at 1 institution in 1 country.
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Abstract
Introduction: Platelets are not only involved in hemostasis and coagulation, but play a significant role in innate immunity and inflammatory response. Excess production of cytokines and acute phase reactants affect megakaryopoiesis resulting in the release of immature platelets from the bone marrow altering platelet indices. Aim: To study platelet indices in RT-PCR-proven COVID patients and non-COVID patients. Methods: A case-control study was conducted on 199 COVID-19 patients and 198 normal individuals. Blood samples were analyzed in an automated hematology analyzer. The platelet indices like platelet count, mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell count (PLCC), and platelet large cell ratio (P-LCR) were compared among two groups. Results: Platelet count in COVID-19 patients were significantly low (p<0.01) compared to controls, and a significant number of COVID-19 patients had thrombocytopenia. Plateletcrit (PCT) was also significantly decreased in COVID-19 patients compared to non-COVID individuals. MPV, PDW, and PLCR were significantly (p<0.05) high in COVID-19 patients in comparison to controls, but was not significantly raised in a large number of cases. In contrast, there were no significant differences in platelet large cell count (PLCC) values between COVID-19 cases and non-COVID-19 controls. Conclusion: Platelet indices like platelet count, PCT, MPV, PDW, and P-LCR are significantly altered in COVID-19 infection and thereby can be used as biomarkers in COVID-19. Further research is needed to find if these simple, cost-effective parameters can be used to predict the severity and prognosis in COVID-19 infection.
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