ArticleEXCLI journal2022
Pupil size as an indicator of cognitive activity in mild Alzheimer's disease.
Article in EXCLI journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Eyes on dementia: an overview of the interplay between eye movements and cognitive decline.Journal of medicine and life · 2023Pooled it
- Simultaneous Analysis of Microsaccades and Pupil Size Variations in Age-Related Cognitive Impairment Using Eye-Tracking Technology.Journal of eye movement research · 2026Article
- Evaluation of Stereopsis Performance, Gaze Direction and Pupil Diameter in Post-COVID Syndrome Using Machine Learning.Biomedicines · 2025Article
- Review
- Comparative analysis of pupillometry in two scheimpflug-based measurement systems.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Pupil responses to social stimuli are associated with adaptive behaviors across the first 24 months of life.Journal of neurodevelopmental disorders · 2025Article
- Ocular changes as potential biomarkers for early diagnosis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Quantifying Mild Cognitive Impairments in Older Adults Using Multi-modal Wearable Sensor Data in a Kitchen Environment.medRxiv : the preprint server for health sciences · 2025Article
- Exploring Retinal Neurodegeneration in Alzheimer's Disease: A Molecular and Cellular Perspective.Neurotoxicity research · 2025Review
- Detecting feigned cognitive impairment using pupillometry on the Warrington Recognition Memory Test for Words.Journal of clinical and experimental neuropsychology · 2024Article
- Potential Retinal Biomarkers in Alzheimer's Disease.International journal of molecular sciences · 2023Review
- The Eye as a Diagnostic Tool for Alzheimer's Disease.Life (Basel, Switzerland) · 2023Review
- The effects of object size on spatial orientation: an eye movement study.Frontiers in neuroscience · 2023Article
- Pupillometry as an index for cognitive processing in behavioral variant FrontoTemporal Dementia: a series of case studies.Neurocase · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well established that pupil activity indexes cognitive processing. For instance, research has consistently demonstrated that the pupil reacts to working memory span task performance. However, little is known about pupil reaction to cognitive processing in Alzheimer's Disease (AD). We thus investigated whether span tasks can modulate pupil size in patients with AD. We invited 24 patients with AD and 24 healthy older adults to perform backward and forward spans, as well as to count aloud in a control condition, while their pupil activity was recorded with eye tracking glasses. In patients with AD, analysis demonstrated larger pupil size during backward spans (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.