Evidence map›Paper›PMID 35382425›Full record

ArticlePediatric investigation2022

Abnormal gait and hypoglycorrhachia in a toddler with seizures.

Maria Angeli, Eleni Vergadi, Georgios Niotakis, Maria Raissaki, Emmanouil Galanakis

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maria AngeliDepartment of Paediatrics University General Hospital of Heraklion, School of Medicine, University of Crete Heraklion Greece.ORCID https://orcid.org/0000-0002-5707-0574
Eleni VergadiDepartment of Paediatrics University General Hospital of Heraklion, School of Medicine, University of Crete Heraklion Greece.
Georgios NiotakisPaediatric Neurology Clinic Venizeleion General Hospital Heraklion Greece.
Maria RaissakiDepartment of Radiology University General Hospital of Heraklion, School of Medicine, University of Crete Heraklion Greece.
Emmanouil GalanakisDepartment of Paediatrics University General Hospital of Heraklion, School of Medicine, University of Crete Heraklion Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Glucose transporter type 1 (Glut1) deficiency syndrome is a treatable neurometabolic disorder characterized by seizures, developmental delay, and hypoglycorrhachia. Due to the rareness and non-specific clinical manifestations, it is usually mis- or underdiagnosed. Case presentation: We report the case of a toddler who presented with afebrile epileptic seizures and abnormal gait. Brain imaging and electroencephalogram were normal. Further investigation of the cerebrospinal fluid revealed hypoglycorrhachia that was the clue to the diagnosis of Glut1 deficiency syndrome and the initiation of treatment with ketogenic diet. Conclusion: Our case highlights the importance of lumbar puncture while investigating a child with epileptic seizures and abnormal gait or developmental delay, in order not to miss treatable neurometabolic conditions, such as Glut1 deficiency syndrome.

Indexed as

AtaxiaDevelopmental delayEpilepsyGlut1 deficiencyHypoglycorrhachia

Identifiers

PMID35382425
PMCPMC8960915

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.