Evidence map›Paper›PMID 35382375›Full record

ArticleArchives of rheumatology2021

Differentiating children with familial Mediterranean fever from other recurrent fever syndromes: The utility of new Eurofever/PRINTO classification criteria.

Rabia Miray Kışla Ekinci, Sibel Balcı, Ahmet Hakan Erol, Dilek Karagöz, Derya Ufuk Altıntaş, Atıl Bisgin

Abstract read
In one paragraph

Article in Archives of rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Familial Mediterranean Fever in Childhood.Turkish archives of pediatrics · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rabia Miray Kışla EkinciDepartment of Pediatrics, Division of Pediatric Rheumatology, Çukurova University Faculty of Medicine, Adana, Turkey.ORCID 0000-0001-6234-822X
Sibel BalcıDepartment of Pediatrics, Division of Pediatric Rheumatology, Çukurova University Faculty of Medicine, Adana, Turkey.ORCID 0000-0003-0099-313X
Ahmet Hakan ErolDepartment of Pediatrics, Çukurova University Faculty of Medicine, Adana, Turkey.ORCID 0000-0002-6991-7648
Dilek KaragözDepartment of Pediatric Allergy and Immunology, Çukurova University Faculty of Medicine, Adana, Turkey.ORCID 0000-0003-3972-7277
Derya Ufuk AltıntaşDepartment of Pediatric Allergy and Immunology, Çukurova University Faculty of Medicine, Adana, Turkey.ORCID 0000-0003-2090-5248
Atıl BisginDepartment of Medical Genetics, Çukurova University Faculty of Medicine, Adana, Turkey.ORCID 0000-0002-2053-9076

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: In this study, we aimed to investigate the performance of Eurofever Registry and the Paediatric Rheumatology International Trials Organisation (PRINTO) classification criteria in pediatric patients with familial Mediterranean fever (FMF). Patients and methods: This retrospective, cross-sectional study included a total of 130 pediatric FMF patients (67 males, 63 females; mean age: 12.4±3.6 years; range, 2.5 to 17.7 years) with at least one M694V mutation in MEFV gene between July 2010 and July 2019. Demographic features and disease characteristics were recorded. The control group was consisted of 41 patients (19 males, 22 females; mean age: 7.8±4.0 years; range, 2.1 to 17.8 years) with other hereditary autoinflammatory diseases (AIDs), including periodic fevers with aphthous stomatitis, pharyngitis, and adenitis syndrome (n=30), mevalonate kinase deficiency (n=9), and tumor necrosis factor receptor-associated periodic syndrome (n=2). Sensitivity and specificity of the Eurofever/PRINTO classification criteria were calculated. Results: The sensitivity and specificity were 97.7% and 56.1% for Yalcinkaya-Ozen criteria, respectively and 93.1% and 90.2% for Tel Hashomer criteria, respectively. The Eurofever/PRINTO classification criteria reached a sensitivity and specificity of 94.6% and 82.9% and 93.1% and 80.5%, respectively, when genetic plus clinical criteria and clinical-only criteria were applied. Conclusion: The Eurofever/PRINTO classification criteria have a comparable sensitivity for avoidance of FMF underdiagnosis in childhood. The Yalcinkaya-Ozen criteria have the highest sensitivity without a significant specificity. The Tel Hashomer criteria and Eurofever/PRINTO classification criteria were superior to Yalcinkaya-Ozen criteria to differentiate FMF from other AIDs, thus leading to less complications relevant to underdiagnosis of other AIDs.

Indexed as

Classificationcriteriafamilial Mediterranean feverpediatric

Identifiers

PMID35382375
PMCPMC8957774

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