ArticleCureus2022
Very Late Recurrence in Breast Cancer: Is Breast Cancer a Chronic Disease?
Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Systematic review of clinical practice guidelines for long-term breast cancer survivorship: assessment of quality and evidence-based recommendations.British journal of cancer · 2025Pooled it
- Self-perceived muscular strength and its correlation with physical, mental, and emotional health status in long-term breast cancer survivors: a cross-sectional study.Journal of cancer survivorship : research and practice · 2026Article
- Natural language processing for local, regional, and distant breast cancer relapse identification in pathology reports.Breast cancer research and treatment · 2025Article
- Emotional Functioning in Long-Term Breast Cancer Survivors: A Cross-Sectional Study on Its Influence and Key Predictors.Cancers · 2025Article
- A Case Report of Atypical Presentation of Metastatic Breast Cancer as Peri-Bronchial Mediastinal Lesion.Cureus · 2024Article
- Article
- A rare case of a solitary osseous metastasis from breast carcinoma presenting with fluid-fluid levels on MRI.International cancer conference journal · 2024Article
- Treatment Classification by Intent in Oncology-The Need for Meaningful Definitions: Curative, Palliative and Potentially Life-Prolonging.Journal of personalized medicine · 2024Article
- Look back in anger: bronchial stenosis secondary to very late recurrence of breast cancer.Einstein (Sao Paulo, Brazil) · 2024Article
- Breast Cancer Recurrence After 46 Years of Remission: A Case Report and Clinical Implications.In vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although breast cancer treatments have made great strides in recent decades, there are still many recurrences. Late recurrence is one of the characteristics of breast cancer. Here, we present four cases of recurrence more than 10 years after the initial diagnosis. The time from diagnosis to recurrence was 13 to 20 years in our four cases, which were all estrogen receptor (ER)-positive, and one was also human epidermal growth factor receptor 2-positive. Long-term hormone therapy for 10 years is necessary to prevent late recurrence of breast cancer, but we need to know that late recurrence remains common. Risk factors for late recurrence include ER positivity, progesterone receptor positivity, and low Ki67. The most common sites of recurrence are the lungs/pleura and bones, which was also the case in our experience. It is no exaggeration to say that breast cancer is a chronic disease similar to hypertension and diabetes. This is because breast cancer is not completely cured by surgery alone and lasts for a long time, with patients requiring long-term hormone therapy. Moreover, it can recur even after 10 years or more.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.