ArticleSurgical endoscopy2022
Gastric subepithelial tumor: long-term natural history and risk factors for progression.
Article in Surgical endoscopy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 11 citations in OpenAlex.
- [Diagnosis and Management of Asymptomatic Upper Gastrointestinal Subepithelial Lesions].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2026Guideline
- Practice Guidelines for the Diagnosis and Treatment of Subepithelial Lesion Observed in Upper Gastrointestinal Endoscopy.Journal of gastroenterology and hepatology · 2026Guideline
- The progression rate and risk factor analysis of small gastric subepithelial tumors: a systematic review and meta-analysis.Surgical endoscopy · 2025Pooled it
- How should we manage incidental gastric subepithelial lesions?Clinical endoscopy · 2026Article
- Natural History of Gastric Subepithelial Tumors: Long-Term Outcomes and Surveillance Strategies.Journal of clinical medicine · 2025Review
- Natural Course of Gastric Subepithelial Tumors.The Korean journal of helicobacter and upper gastrointestinal research · 2025Review
- A Subepithelial Lesion of the Stomach Observed During Screening Endoscopy.The Korean journal of helicobacter and upper gastrointestinal research · 2025Article
- Practice Guidelines for the Diagnosis and Treatment of Subepithelial Lesions Observed in Upper Gastrointestinal Endoscopy.The Korean journal of helicobacter and upper gastrointestinal research · 2025Review
- [Gastric Undifferentiated Pleomorphic Sarcoma Presenting as a Rapidly Growing Subepithelial Tumor].The Korean journal of helicobacter and upper gastrointestinal research · 2024Article
- Prevalence and natural course of incidental gastric subepithelial tumors.Clinical endoscopy · 2024Article
- Natural history of gastric leiomyoma.Surgical endoscopy · 2024Article
- Artificial Intelligence in the Prediction of Gastrointestinal Stromal Tumors on Endoscopic Ultrasonography Images: Development, Validation and Comparison with Endosonographers.Gut and liver · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSubepithelial tumors are often detected incidentally during upper gastrointestinal endoscopy. However, their natural history and clinical management have yet to be clearly established. The aim of this study was to evaluate the natural history and risk factors for progression of gastric SETs.
methodsThe study retrospectively reviewed the medical records of patients who were diagnosed with gastric SET using upper gastrointestinal endoscopy between January 2005 and December 2017. Tumor progression was defined by a ≥ 25% increase in diameter.
resultsAmong 3237 patients, 1859 underwent serial upper gastrointestinal endoscopy for more than six months. Endoscopic ultrasonography was further performed in 733 (39.43%) patients. Resection was performed in 73 (3.93%) patients. Tumor progressed in 138 (7.42%) patients over a mean follow-up period of 59.41 months (range, 5-215 months). In progressed tumors, the mean initial size was 15.01 mm (range, 2-50 mm) and the mean size increment was 12.86 mm (range, 3-50 mm). Large initial tumor size (OR: 1.03, 95% CI: 1.01-1.05), surface ulcer or erosion (OR: 2.47, 95% CI: 1.21-5.06), lobulated shape (OR: 3.76, 95% CI: 2.00-7.06), and middle-third location (OR: 1.65, 95% CI: 1.08-2.52) were significant risk factors for tumor progression. Large SETs had higher rates of progression and tended to grow faster than smaller tumors (r = 0.44, p < 0.001).
conclusionsThe majority of gastric SETs did not increase in size during the long-term follow-up. Serial endoscopy may be sufficient as a follow-up tool for small SETs with intact overlying mucosa without lobulated shape.
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