Evidence map›Paper›PMID 35381208›Full record

ReviewBiochemical pharmacology2022

"Selective" serotonin 5-HT

Austen B Casey, Meng Cui, Raymond G Booth, Clinton E Canal

Open access · greenAbstract readReview
In one paragraph

Review in Biochemical pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Desloratadine as the selective 5HTJournal of neuroinflammation · 2025
    Article
  13. Psychedelic 5-HTNature neuroscience · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. The Selective 5HTSynapse (New York, N.Y.) · 2025
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Austen B CaseyDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: abcasey@stanford.edu.
Meng CuiDepartment of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA; Center for Drug Discovery, Northeastern University, Boston, MA 02115, USA.
Raymond G BoothDepartment of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA; Center for Drug Discovery, Northeastern University, Boston, MA 02115, USA.
Clinton E CanalDepartment of Pharmaceutical Sciences, College of Pharmacy, Mercer University Health Sciences Center, Mercer University, 3001 Mercer University Drive, Atlanta, GA 30341, USA.
Northeastern University · USMercer University Health Sciences Center · USStanford University · US

Funding

Delineating the role of serotonin 5-HT2 receptors in opioid use disorders:Development of novel 5-HT2 modulators with translational studies in rodents andprimatesR01DA047130 · NIDA · NORTHEASTERN UNIVERSITY · PI BOOTH, RAYMOND G., KOHUT, STEPHEN JOHN · 2018 to 2022
$3.2M
Novel Functionally-Selective Serotonin 5HT2 Drugs for Amphetamines Abuse/DisorderR01DA030989 · NIDA · UNIVERSITY OF FLORIDA · PI BOOTH, RAYMOND G., MORGAN, DRAKE · 2010 to 2014
$1.6M
Targeting Serotonin 5-HT1A and 5-HT7 Receptors to Prevent Audiogenic Seizures and Correct Translationally Valid EEG Phenotypes in a Juvenile Fmr1 Knock-Out Mouse Model of Fragile X SyndromeR15NS118352 · NINDS · MERCER UNIVERSITY MACON · PI CANAL, CLINTON E · 2020 to 2020
$424k
NIDA NIH HHS R01 DA030989NIDA NIH HHS R01 DA047130NINDS NIH HHS R15 NS118352
6 · The paper itself

Abstract

Blockade of the serotonin 5-HT

Indexed as

HallucinogensMajor Depressive DisorderHumansReceptor, Serotonin, 5-HT2ASerotoninSerotonin 5-HT2 Receptor AgonistsHallucinogensReceptor, Serotonin, 5-HT2ASerotoninSerotonin 5-HT2 Receptor Agonists5-HT(2A)AntagonistAntipsychoticGPCRSelectivity

Identifiers

PMID35381208
PMCPMC9252399
OpenAlexW4224861883

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.