ArticleCell2022
LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma.
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Article in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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92citing papers in PubMed
19.8field-weighted citation impact, top 1% of its field
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92 citing papers in PubMed, 144 citations in OpenAlex.
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- Contribution of HMGB1 to keratinocyte inflammation in recessive dystrophic epidermolysis bullosa.JID innovations : skin science from molecules to population health · 2026Article
- Aberrant and ectopic cell populations in restrictive allograft syndrome after lung transplantation.The European respiratory journal · 2026Article
- An endometrial immune atlas across the female menstrual cycle reveals lymphoid aggregates compromise pregnancy.Nature communications · 2026Article
- An Integrated Multi-omics Single Cell Atlas of the Human RPE and Choroid.bioRxiv : the preprint server for biology · 2026Article
- Fibroblasts: a diverse population of cells balancing homeostasis, wound healing, regeneration, inflammation, fibrosis, and cancer across organs.JCI insight · 2026Review
- Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis.Annals of the rheumatic diseases · 2026Article
- Spatial Orchestration of Skin Fibrosis by a CD8+ T cell- Myofibroblast Axis.bioRxiv : the preprint server for biology · 2026Article
- Predicting gene essentiality and drug response from preclinical perturbation screens with layered ensemble of autoencoders and predictors.Scientific reports · 2026Article
- Single-nucleus analysis reveals human-specific oligodendrocyte polarization and conserved neuronal responses after severe traumatic brain injury.Nature communications · 2026Article
- Deep phenotyping of skin tissue remodeling in patients with systemic sclerosis treated with CD19-CAR T cells.Nature communications · 2026Article
- A phenotype-to-mechanism framework links phenome-wide comorbidity architecture to molecular mechanisms and therapeutic discovery in complex diseases.medRxiv : the preprint server for health sciences · 2026Article
- Predicting enhancer-gene links from single-cell multi-omics data by integrating prior Hi-C information.Nucleic acids research · 2026Article
- Identification of stem cell marker-positive subpopulations in the vocal fold of the larynx through transcriptomic analyses.Nature communications · 2026Article
- Skin Transcriptomics Reveal Shared Molecular Mechanisms for Skin and Lung Involvement in Systemic Sclerosis.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Reciprocal regulation of fibroblast-macrophage equilibrium governs skin integrity.Nature immunology · 2026Article
- Mechanisms of fibrotic tissue remodelling: insights from systemic sclerosis.Nature reviews. Rheumatology · 2026Review
- Transcriptional landscape of CD4+ T cells in Systemic Sclerosis.bioRxiv : the preprint server for biology · 2026Article
32 more citing papers are in PubMed but not listed here.
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Authors and funding
41 authors at 4 institutions in 1 country.
Chamutal GurDepartment of Systems Immunology, Weizmann Institute, Rehovot, Israel; Rheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Shuang-Yin WangDepartment of Systems Immunology, Weizmann Institute, Rehovot, Israel. Electronic address: shuangyinwang@me.com.
Fadi ShebanDepartment of Systems Immunology, Weizmann Institute, Rehovot, Israel.
Mor ZadaDepartment of Systems Immunology, Weizmann Institute, Rehovot, Israel.
Baoguo LiDepartment of Systems Immunology, Weizmann Institute, Rehovot, Israel.
Fadi KharoufRheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Hagit PelegRheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Suhail AamarRheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Adam YalinDepartment of Systems Immunology, Weizmann Institute, Rehovot, Israel.
Daniel KirschenbaumDepartment of Systems Immunology, Weizmann Institute, Rehovot, Israel.
Yolanda Braun-MoscoviciRheumatology Institute, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion-Israeli Institute of Technology, Haifa, Israel.
Diego Adhemar JaitinDepartment of Systems Immunology, Weizmann Institute, Rehovot, Israel.
Tomer Meir-SalameFlow Cytometry Unit, Department of Biological Services, Weizmann Institute, Rehovot, Israel.
Efrat HagaiFlow Cytometry Unit, Department of Biological Services, Weizmann Institute, Rehovot, Israel.
Bjørt K KragesteenDepartment of Systems Immunology, Weizmann Institute, Rehovot, Israel.
Batia AvniDepartment of Bone Marrow Transplantation, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Sigal GrisariuDepartment of Bone Marrow Transplantation, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Chamutal BornsteinDepartment of Systems Immunology, Weizmann Institute, Rehovot, Israel.
Shir Shlomi-LoubatonDepartment of Systems Immunology, Weizmann Institute, Rehovot, Israel.
Eyal DavidDepartment of Systems Immunology, Weizmann Institute, Rehovot, Israel.
Rony Shreberk-HassidimDermatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Vered Molho-PessachDermatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Dalit AmarPlastic Surgery Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Tomer TzurPlastic Surgery Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Rottem KuintInstitue of Pulmonology Medicine, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Moshe GrossOrthopedic Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Oren BarboyDepartment of Systems Immunology, Weizmann Institute, Rehovot, Israel.
Adi MosheDepartment of Systems Immunology, Weizmann Institute, Rehovot, Israel.
Liat Fellus-AlyagorThe Department of Veterinary Resources, Weizmann Institute, Rehovot, Israel.
Dana HirschThe Department of Veterinary Resources, Weizmann Institute, Rehovot, Israel.
Yoseph AddadiLife Sciences Core Facilities, Weizmann Institute, Rehovot, Israel.
Shlomit ErenfeldDepartment of Bone Marrow Transplantation, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Moshe BitonDepartment of Biological Regulation, Weizmann Institute, Rehovot, Israel.
Tehila TzemachRheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Anat ElazaryRheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Yaakov NaparstekRheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Reut TzemachDepartment of Systems Immunology, Weizmann Institute, Rehovot, Israel; Rheumatology Institute at the Tel Aviv Sourasky Medical Center, Tel Aviv-Yafo, Israel.
Assaf WeinerDepartment of Systems Immunology, Weizmann Institute, Rehovot, Israel.
Amir GiladiDepartment of Systems Immunology, Weizmann Institute, Rehovot, Israel.
Alexandra Balbir-GurmanRheumatology Institute, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion-Israeli Institute of Technology, Haifa, Israel.
Ido AmitDepartment of Systems Immunology, Weizmann Institute, Rehovot, Israel. Electronic address: ido.amit@weizmann.ac.il.
Weizmann Institute of Science · ILHebrew University of Jerusalem · ILRambam Health Care Campus · ILTel Aviv Sourasky Medical Center · IL
Funding
European Research Council 724471
Abstract
Systemic sclerosis (scleroderma, SSc) is an incurable autoimmune disease with high morbidity and mortality rates. Here, we conducted a population-scale single-cell genomic analysis of skin and blood samples of 56 healthy controls and 97 SSc patients at different stages of the disease. We found immune compartment dysfunction only in a specific subtype of diffuse SSc patients but global dysregulation of the stromal compartment, particularly in a previously undefined subset of LGR5
Indexed as
Scleroderma, SystemicCells, CulturedFibroblastsFibrosisHumansReceptors, G-Protein-CoupledSkinLGR5 protein, humanReceptors, G-Protein-CoupledautoimmunefibroblastfibrosisFOSGVHDLGR5skinsystemic sclerosisTWIST1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.