ArticleNeuron2022
Hippocampal replays appear after a single experience and incorporate greater detail with more experience.
Article in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 61 citations in OpenAlex.
- Article
- The hippocampus as a small-world cognitive map.bioRxiv : the preprint server for biology · 2026Article
- The Role of Plasticity in Replay: Stability Through Anti-Hebbian Rules.Hippocampus · 2026Article
- Distinct CA3 inputs differentially shape the learning-dependent evolution of right CA1 spatial maps.Nature communications · 2026Article
- Article
- Subspace communication in the hippocampal-retrosplenial axis.bioRxiv : the preprint server for biology · 2026Article
- Adaptation of hippocampal spatial and contextual representations to task structure.Science advances · 2025Article
- Pre-existing and emergent cortical neuronal assembly sequences during learning.bioRxiv : the preprint server for biology · 2025Article
- Ripple contributions to human memory: making the spiking content count.Nature reviews. Neuroscience · 2025Review
- Learning-Dependent Shift from Right to Left CA3 Input Dominance Shapes the Evolution of Right CA1 Spatial Maps.bioRxiv : the preprint server for biology · 2025Article
- Article
- Generative emergence of non-local representations in the hippocampus.Nature communications · 2025Article
- Representational drift as the consequence of ongoing memory storage.Scientific reports · 2025Article
- Hippocampal Place Cell Sequences Are Impaired in a Rat Model of Fragile X Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Exploring replay.Nature communications · 2025Article
- Hippocampal place cell sequences are impaired in a rat model of Fragile X Syndrome.bioRxiv : the preprint server for biology · 2025Article
- Spatial localization of hippocampal replay requires dopamine signaling.bioRxiv : the preprint server for biology · 2024Article
- Topography of putative bidirectional interaction between hippocampal sharp wave ripples and neocortical slow oscillations.bioRxiv : the preprint server for biology · 2024Article
- Intrinsic dynamics of randomly clustered networks generate place fields and preplay of novel environments.eLife · 2024Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
The hippocampus is implicated in memory formation, and neurons in the hippocampus take part in replay sequences that have been proposed to reflect memory of explored space. By recording from large ensembles of hippocampal neurons as rats explored various tracks, we show that sustained replay appears after a single experience. Further, we found that with repeated experience in a novel environment, replay slows down, taking more time to traverse the same trajectory. This effect was dependent on experience, not passage of time, and was environment specific. By investigating the slow-gamma (25-50 Hz) hover-and-jump dynamics within replays, we show that replay slows by adding more hover locations, increasing the resolution of the behavioral trajectory. We provide evidence that inhibition and cortical engagement both increase as replay slows. Thus, replays can reflect single experiences and evolve with re-exposure, in a manner consistent with the encoding of greater detail into replay memories with experience.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.