ArticleMagnetic resonance in medicine2022
The influence of cystathionine on neurochemical quantification in brain tumor in vivo MR spectroscopy.
Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 11 citations in OpenAlex.
- Metabolite ratiomics: Rapid diagnosis and classification of gliomas for intraoperative application during brain surgery.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Transverse Relaxation Time Constant of Cystathionine in Human Glioma at 3 T.Magnetic resonance in medicine · 2026Article
- The diagnostic value of cortical high-flow sign combined with cystathionine onNeuroradiology · 2026Article
- A data-driven algorithm to determineMagnetic resonance in medicine · 2026Article
- Ambient ionization mass spectrometry in brain cancer diagnosis.Journal of mass spectrometry and advances in the clinical lab · 2025Review
- TE optimization for J-difference editing of 2-hydroxyglutarate at 3T.Magnetic resonance in medicine · 2025Article
- Incorporation of Edited MRS into Clinical Practice May Improve Care of Patients withAJNR. American journal of neuroradiology · 2025Article
- Optimization and validation of echo times of point-resolved spectroscopy for cystathionine detection in gliomas.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- Neurochemical Differences between 1p/19q Codeleted and Noncodeleted IDH-mutant Gliomas by in Vivo MR Spectroscopy.Radiology · 2023Observational
- Pitfalls in 2HG Detection With TE-Optimized MRS at 3T.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
- Accurate prediction of isocitrate dehydrogenase -mutation status of gliomas using SLOW-editing magnetic resonance spectroscopic imaging at 7 T MR.Neuro-oncology advancesArticle
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
purposeTo evaluate the ability of the PRESS sequence (T
methodsTwenty-three subjects with a glioma were retrospectively included based on the availability of both MEGA-PRESS and PRESS acquisitions at 3T, and the presence of the cystathionine signal in the edited MR spectrum. In eight subjects, the PRESS acquisition was performed also in normal tissue. Metabolite quantification was performed using LCModel and simulated basis sets. The LCModel analysis for the PRESS data was performed with and without cystathionine.
resultsAll subjects with glioma had detectable cystathionine levels >1 mM with Cramér-Rao lower bounds (CRLB) <15%. The mean cystathionine concentrations were 3.49 ± 1.17 mM for MEGA-PRESS and 2.20 ± 0.80 mM for PRESS data. Cystathionine concentrations showed a significant correlation between the two MRS methods (r = 0.58, p = .004), and it was not detectable in normal tissue. Using PRESS, 19 metabolites were quantified with CRLB <50% for more than half of the subjects. The metabolites that were significantly (p < .0028) and mostly affected by the omission of cystathionine were aspartate, betaine, citrate, γ-aminobutyric acid (GABA), and serine.
conclusionsCystathionine was detectable by PRESS in all the selected gliomas, while it was not detectable in normal tissue. The omission from the spectral analysis of cystathionine led to severe biases in the quantification of other neurochemicals that may play key roles in cancer metabolism.
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