ArticleAngewandte Chemie (International ed. in English)2022
Divergent Asymmetric Synthesis of Panowamycins, TM-135, and Veramycin F Using C-H Insertion with Donor/Donor Carbenes.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Enantioselective Synthesis of Spirolactones and Spirolactams Under Low Catalyst Loadings.Journal of the American Chemical Society · 2026Article
- Enantioselective C-H functionalization: logic and applications in the total synthesis of natural products.Chemical science · 2026Review
- Asymmetric Synthesis of Cycloartobiloxanthone.Organic letters · 2025Article
- Ligand-controlled divergent asymmetric C(spNature communications · 2025Article
- Palladium-catalyzed intramolecular enantioselective C(spChemical science · 2022Article
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5 authors.
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Abstract
Panowamycins are a group of isochroman-based natural products first isolated from Streptomyces sp. K07-0010 in 2012 by Satoshi Ōmura and co-workers that exhibit modest anti-trypanosomal activity. Herein we demonstrate the first syntheses of these natural products and their epimers. Stereoselective dirhodium-catalyzed C-H insertion reactions with a donor/donor carbene construct the substituted isochroman core in the key bond-forming step. The syntheses are completed without the use of protecting groups and feature a late-stage Wacker oxidation. Incongruent NMR spectra between natural and synthetic samples revealed the structural misassignment of panowamycin A and veramycin F. Computational NMR studies suggested panowamycin A to be an alternate diastereomer, which was confirmed by synthesizing this isomer. Concurrent with this work, in 2021 Mahmud and co-workers came to the same conclusion with an updated NMR analysis of panowamycin A. In a divergent, asymmetric sequence, we report the synthesis of panowamycin A, panowamycin B, TM-135, and veramycin F.
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