Evidence map›Paper›PMID 35380879›Full record

ArticleScience signaling2022

The

Spyridoula-Angeliki Nikou, Chunsheng Zhou, James S Griffiths, Natalia K Kotowicz, Bianca M Coleman, Mary J Green, David L Moyes, Sarah L Gaffen, Julian R Naglik, Peter J Parker

Open access · greenAbstract read
In one paragraph

Article in Science signaling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Hemolytic Activity of VaginalPathogens (Basel, Switzerland) · 2026
    Article
  5. Article
  6. mBio · 2026
    Article
  7. Article
  8. Article
  9. The V-ATPase VJournal of oral microbiology · 2026
    Article
  10. The pathogenicity and future treatment strategies ofFrontiers in cellular and infection microbiology · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. The multi-kingdom cancer microbiome.Nature microbiology · 2025
    Review
  16. Review
  17. Review
  18. Article
  19. Infection and immunity · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Spyridoula-Angeliki NikouProtein Phosphorylation Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0003-4330-8606
Chunsheng ZhouDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-9721-7948
James S GriffithsCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK.ORCID 0000-0002-7147-2465
Natalia K KotowiczCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK.ORCID 0000-0001-9637-4119
Bianca M ColemanDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-4276-7456
Mary J GreenExperimental Histopathology Laboratory, Francis Crick Institute, London, UK.
David L MoyesCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK.ORCID 0000-0002-1657-918X
Sarah L GaffenDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-8511-2041
Julian R NaglikCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK.ORCID 0000-0002-8072-7917
Peter J ParkerProtein Phosphorylation Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0001-5907-6980
King's College London · GBUniversity of Pittsburgh · USThe Francis Crick Institute · GB

Funding

Host and Fungal Regulation of Type 17 Immunity to Oral CandidiasisR37DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sarah L Gaffen · 2017 to 2026
$5.6M
IL-17 Receptor Signaling in the Oral MucosaR01DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2012 to 2016
$2.1M
Cancer Research UK FC001130Department of Health IS-BRC-1215-20006NIDCR NIH HHS R01 DE022550NIDCR NIH HHS R37 DE022550Wellcome Trust 214229Wellcome Trust FC001130
6 · The paper itself

Abstract

The fungal pathogen

Indexed as

Candida albicansFungal ProteinsMAP Kinase Signaling SystemAnimalsErbB ReceptorsMicep38 Mitogen-Activated Protein KinasesPhosphorylationECE1 protein, Candida albicansErbB ReceptorsFungal Proteinsp38 Mitogen-Activated Protein Kinases

Identifiers

PMID35380879
PMCPMC7612652
OpenAlexW4224015814

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.