ArticleBiochemistry2022
Substrate-Triggered μ-Peroxodiiron(III) Intermediate in the 4-Chloro-l-Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, the Intermediate.
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Article in Biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed.
- Recent discoveries in mono- and dinuclear nonheme iron enzymes: Emerging mechanisms and catalytic strategies.Archives of biochemistry and biophysics · 2026Review
- Unveiling Putative Functions of Burkholderia pseudomallei K96243 Hypothetical Proteins Via High-Throughput Characterization of Structural Similarities.Interdisciplinary sciences, computational life sciences · 2026Article
- Discovery of a Structurally Distinct Acetylenase in the Biosynthesis of Mangotoxin.Journal of the American Chemical Society · 2026Article
- Crystal structure of RohS, a heme-oxygenase-like N-oxygenase from azomycin biosynthesis.The Journal of biological chemistry · 2026Article
- Heme oxygenase-like dimetal oxidases and oxygenases.Biochemical Society transactions · 2026Review
- Azetidine amino acid biosynthesis by non-haem iron-dependent enzymes.Nature chemistry · 2026Article
- A two-metalloenzyme cascade constructs the azetidine-containing pharmacophore.Nature chemistry · 2026Article
- A ferritin-like diiron oxygenase BioE initiates bacterial biotin synthesis, a promising antivirulence target.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Discovery and Mechanism of a Diiron Enzyme in Ethylidene Azetidine Formation.Journal of the American Chemical Society · 2025Article
- The Heme Oxygenase-Like Diiron Enzyme HrmI Reveals Altered Regulatory Mechanisms for Dioxygen Activation and Substrate N-Oxygenation.Journal of the American Chemical Society · 2025Article
- Heme Oxygenase-Like Metalloenzymes.Annual review of biochemistry · 2025Review
- Nature of the Reactive Biferric Peroxy Intermediate P' in the Arylamine Oxygenases and Related Binuclear Fe Enzymes.Journal of the American Chemical Society · 2025Article
- Biochemical characterization of the self-sacrificing p-aminobenzoate synthase from Nitrosomonas europaea reveals key residues involved in selecting a Fe/Fe or Mn/Fe cofactor.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025Article
- Copper-chelating natural products.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025Review
- Single-Enzyme Conversion of Tryptophan to Skatole and Cyanide Expands the Mechanistic Competence of Diiron Oxidases.Journal of the American Chemical Society · 2025Article
- A single diiron enzyme catalyses the oxidative rearrangement of tryptophan to indole nitrile.Nature chemistry · 2024Article
- Assembly of a Heterobimetallic Fe/Mn Cofactor in theBiochemistry · 2024Article
- Structural Basis for Methine Excision by a Heme Oxygenase-like Enzyme.ACS central science · 2024Article
- Reconstitution of the Final Steps in the Biosynthesis of Valanimycin Reveals the Origin of Its Characteristic Azoxy Moiety.Angewandte Chemie (International ed. in English) · 2024Article
- The structural and functional investigation into an unusual nitrile synthase.Nature communications · 2023Article
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Authors and funding
9 authors.
Molly J McBrideDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0003-3832-1355
Mrutyunjay A NairDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Debangsu SilDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Jeffrey W SlaterDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0002-1126-8905
Monica E NeugebauerDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, California 94720, United States.
Michelle C Y ChangDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, California 94720, United States.ORCID 0000-0003-3747-7630
Amie K BoalDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0002-1234-8472
Carsten KrebsDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0002-3302-7053
J Martin BollingerDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0003-0751-8585
Funding
Mapping the Structural Basis for Mechanistic Diversity in Metalloenzyme SuperfamiliesR35GM119707 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Amie K Boal · 2016 to 2026
$5.0MMechanisms of Mononuclear non-Heme-Iron EnzymesR35GM127079 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CARSTEN KREBS · 2018 to 2026
$3.8MStructures and Mechanisms of “Heme-oxygenase-like” Non-heme Di-iron Enzymes that Catalyze Complex N-oxygenation and Olefin-installing C–C-Fragmentation ReactionsR01GM138580 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BOLLINGER, JOSEPH M · 2020 to 2023
$1.3MStructure determination of reaction intermediates in macromolecular complexesR00GM100011 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BOAL, AMIE K · 2013 to 2015
$729kInterrogating the Haloferryl State of Iron(II)- and 2-Oxoglutarate-Dependent Halogenases through Mimicry and Active Site ModificationsF32GM136156 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI SLATER, JEFFREY WORTHINGTON · 2020 to 2022
$201kNIGMS NIH HHS F32 GM136156NIGMS NIH HHS R00 GM100011NIGMS NIH HHS R01 GM138580NIGMS NIH HHS R35 GM119707NIGMS NIH HHS R35 GM127079
Abstract
The enzyme BesC from the
Indexed as
Heme Oxygenase (Decyclizing)OxidoreductasesAllylglycineHemeLysineOxygenOxygenasesPeroxidesAllylglycineHemeHeme Oxygenase (Decyclizing)LysineOxidoreductasesOxygenOxygenasesPeroxides
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