Evidence map›Paper›PMID 35380492›Full record

ArticleRadiology2022

Fully Automated Abdominal CT Biomarkers for Type 2 Diabetes Using Deep Learning.

Hima Tallam, Daniel C Elton, Sungwon Lee, Paul Wakim, Perry J Pickhardt, Ronald M Summers

Open access · greenAbstract read
In one paragraph

Article in Radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
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  4. Landmark-Based Pancreas Sub-region Segmentation in CT.Journal of imaging informatics in medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hima TallamFrom the Department of Radiology and Imaging Sciences (H.T., D.C.E., S.L., R.M.S.) and Department of Biostatistics and Clinical Epidemiology Service (P.W.), Clinical Center, National Institutes of Health, 10 Center Dr, Bldg 10, Room 1C224D, MSC 1182, Bethesda, MD 20892-1182; and Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (P.J.P.).ORCID 0000-0001-7749-4502
Daniel C EltonFrom the Department of Radiology and Imaging Sciences (H.T., D.C.E., S.L., R.M.S.) and Department of Biostatistics and Clinical Epidemiology Service (P.W.), Clinical Center, National Institutes of Health, 10 Center Dr, Bldg 10, Room 1C224D, MSC 1182, Bethesda, MD 20892-1182; and Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (P.J.P.).ORCID 0000-0003-0249-1387
Sungwon LeeFrom the Department of Radiology and Imaging Sciences (H.T., D.C.E., S.L., R.M.S.) and Department of Biostatistics and Clinical Epidemiology Service (P.W.), Clinical Center, National Institutes of Health, 10 Center Dr, Bldg 10, Room 1C224D, MSC 1182, Bethesda, MD 20892-1182; and Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (P.J.P.).ORCID 0000-0002-1684-2996
Paul WakimFrom the Department of Radiology and Imaging Sciences (H.T., D.C.E., S.L., R.M.S.) and Department of Biostatistics and Clinical Epidemiology Service (P.W.), Clinical Center, National Institutes of Health, 10 Center Dr, Bldg 10, Room 1C224D, MSC 1182, Bethesda, MD 20892-1182; and Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (P.J.P.).ORCID 0000-0002-5951-0983
Perry J Pickhardt *From the Department of Radiology and Imaging Sciences (H.T., D.C.E., S.L., R.M.S.) and Department of Biostatistics and Clinical Epidemiology Service (P.W.), Clinical Center, National Institutes of Health, 10 Center Dr, Bldg 10, Room 1C224D, MSC 1182, Bethesda, MD 20892-1182; and Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (P.J.P.).ORCID 0000-0002-5534-8202
Ronald M Summers *From the Department of Radiology and Imaging Sciences (H.T., D.C.E., S.L., R.M.S.) and Department of Biostatistics and Clinical Epidemiology Service (P.W.), Clinical Center, National Institutes of Health, 10 Center Dr, Bldg 10, Room 1C224D, MSC 1182, Bethesda, MD 20892-1182; and Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (P.J.P.).ORCID 0000-0001-8081-7376
National Institutes of Health Clinical Center · US

Funding

Computer Aided Detection for CT ColonographyZIACL040003 · CLC · CLINICAL CENTER · PI SUMMERS, RONALD M. · 2009 to 2025
$0k
6 · The paper itself

Abstract

Background CT biomarkers both inside and outside the pancreas can potentially be used to diagnose type 2 diabetes mellitus. Previous studies on this topic have shown significant results but were limited by manual methods and small study samples. Purpose To investigate abdominal CT biomarkers for type 2 diabetes mellitus in a large clinical data set using fully automated deep learning. Materials and Methods For external validation, noncontrast abdominal CT images were retrospectively collected from consecutive patients who underwent routine colorectal cancer screening with CT colonography from 2004 to 2016. The pancreas was segmented using a deep learning method that outputs measurements of interest, including CT attenuation, volume, fat content, and pancreas fractal dimension. Additional biomarkers assessed included visceral fat, atherosclerotic plaque, liver and muscle CT attenuation, and muscle volume. Univariable and multivariable analyses were performed, separating patients into groups based on time between type 2 diabetes diagnosis and CT date and including clinical factors such as sex, age, body mass index (BMI), BMI greater than 30 kg/m

Indexed as

Deep LearningDiabetes Mellitus, Type 2BiomarkersFemaleHumansMiddle AgedRetrospective StudiesTomography, X-Ray ComputedBiomarkers

Identifiers

PMID35380492
PMCPMC9270681
OpenAlexW4225813841

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.