Evidence map›Paper›PMID 35380453›Full record

ArticlemBio2022

Titration of C-5 Sterol Desaturase Activity Reveals Its Relationship to Candida albicans Virulence and Antifungal Susceptibility Is Dependent upon Host Immune Status.

Jessica Regan, Christian DeJarnette, Arturo Luna-Tapia, Josie E Parker, Parker Reitler, Stacey Barnett, Katie M Tucker, Steven L Kelly, Glen E Palmer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Jessica Regan *Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.
Christian DeJarnette *Department of Molecular Immunology and Biochemistry, College of Graduate Health Sciences, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.
Arturo Luna-TapiaDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.
Josie E ParkerInstitute of Life Science, Swansea Universitygrid.4827.9 Medical School, Swansea, Wales, United Kingdom.
Parker ReitlerDepartment of Molecular Immunology and Biochemistry, College of Graduate Health Sciences, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.
Stacey BarnettLaboratory Animal Care Unit, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.
Katie M TuckerDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.
Steven L KellyInstitute of Life Science, Swansea Universitygrid.4827.9 Medical School, Swansea, Wales, United Kingdom.
Glen E PalmerDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.ORCID 0000-0003-4083-3130
University of Tennessee Health Science Center · USSwansea University · GB

Funding

Antifungal antagonism as a cause of treatment failure for invasive mycosesR01AI152067 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI PALMER, GLEN · 2021 to 2025
$3.1M
Broad spectrum antifungals targeting fatty acid biosynthesisR33AI127607 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI PALMER, GLEN · 2019 to 2022
$1.5M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI152067NIAID NIH HHS R01 AI152067NIAID NIH HHS R33 AI127607
6 · The paper itself

Abstract

The azole antifungals inhibit sterol 14α-demethylase (S14DM), which depletes cellular ergosterol and promotes synthesis of the dysfunctional lipid 14α-methylergosta-8,24(28)-dien-3β,6α-diol, ultimately arresting growth. Mutations that inactivate sterol Δ

Indexed as

Antifungal AgentsCandida albicansAnimalsAzolesFluconazoleHumansMammalsMiceMicrobial Sensitivity TestsOxidoreductasesSterolsVirulenceAntifungal AgentsAzolesFluconazoleOxidoreductasessterol delta-5 desaturaseSterolsantifungal efficacyC-5 sterol desaturaseCandida albicansERG3fluconazolepathogenicityvirulenceyeasts

Identifiers

PMID35380453
PMCPMC9040724
OpenAlexW4224937255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.