Evidence map›Paper›PMID 35380371›Full record

ArticleJournal of racial and ethnic health disparities2023

Clinical Trial Participation and COVID-19: a Descriptive Analysis from the American Heart Association's Get With The Guidelines Registry.

Kevin S Shah, Adriana E Reyes-Miranda, Steven M Bradley, Khadijah Breathett, Sandeep R Das, Ty J Gluckman, Divya Gupta, Daniel T Leung, R Kannan Mutharasan, Pamela N Peterson and 2 more

Abstract read
In one paragraph

Article in Journal of racial and ethnic health disparities, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Lessons From COVID-19 for Pandemic Preparedness: Proceedings From a Multistakeholder Think Tank.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kevin S ShahDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Utah School of Medicine, 30 N. 1900 E, Room 4A100, UT, 84132, Salt Lake City, USA. Kevin.Shah@hsc.utah.edu.
Adriana E Reyes-MirandaDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Utah School of Medicine, 30 N. 1900 E, Room 4A100, UT, 84132, Salt Lake City, USA.
Steven M BradleyMinneapolis Heart Institute and Minneapolis Heart Institute Foundation, Minneapolis, MN, USA.
Khadijah BreathettDivision of Cardiovascular Medicine, Sarver Heart Center, University of Arizona, Tucson, AZ, USA.
Sandeep R DasDepartment of Internal Medicine, Cardiology Division, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ty J GluckmanCenter for Cardiovascular Analytics, Research and Data Science (CARDS), Providence Heart Institute, Portland, OR, USA.
Divya GuptaDivision of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.
Daniel T LeungDivision of Infectious Diseases, University of Utah School of Medicine, Salt Lake City, UT, USA.
R Kannan MutharasanDivision of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Pamela N PetersonDenver Health Medical Center, Denver, CO, USA.
Emily S SpivakDivision of Infectious Diseases, University of Utah School of Medicine, Salt Lake City, UT, USA.
Rashmee U ShahDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Utah School of Medicine, 30 N. 1900 E, Room 4A100, UT, 84132, Salt Lake City, USA.

Funding

UCSF Research in Implementation Sciences for Equity (RISE)R25HL126146 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRYSTAL WILEY CENE, Alicia Fernandez · 2014 to 2026
$4.6M
Seeking Objectivity in Allocation of Advanced Heart Failure (SOCIAL HF) Therapies TrialR56HL159216 · NHLBI · UNIVERSITY OF ARIZONA · PI BREATHETT, KHADIJAH · 2021 to 2021
$906k
Addressing Individual Provider Bias and Group Decision-Making in Selection of Advanced Heart Failure Therapies in Racial/Ethnic MinoritiesK01HL142848 · NHLBI · UNIVERSITY OF ARIZONA · PI BREATHETT, KHADIJAH · 2018 to 2021
$858k
Improving Cardiovascular Drug Safety With Automated Bleeding ClassificationK08HL136850 · NHLBI · UNIVERSITY OF UTAH · PI SHAH, RASHMEE U. · 2017 to 2020
$652k
NHLBI NIH HHS K01 HL142848NHLBI NIH HHS K01HL142848NHLBI NIH HHS K08 HL136850NHLBI NIH HHS K08HL136850NHLBI NIH HHS L30 HL148881NHLBI NIH HHS L30HL148881NHLBI NIH HHS R25 HL126146NHLBI NIH HHS R25HL126146NHLBI NIH HHS R56 HL159216
6 · The paper itself

Abstract

As COVID-19 cases begin to decrease in the USA, learning from the pandemic experience will provide insights regarding disparities of care delivery. We sought to determine if specific populations hospitalized with COVID-19 are equally likely to be enrolled in clinical trials. We examined patients hospitalized with COVID-19 at centers participating in the American Heart Association's COVID-19 CVD Registry. The primary outcome was odds of enrollment in a clinical trial, according to sex, race, and ethnicity. Among 14,397 adults hospitalized with COVID-19, 9.5% (n = 1,377) were enrolled in a clinical trial. The proportion of enrolled patients was the lowest for Black patients (8%); in multivariable analysis, female and Black patients were less likely to be enrolled in a clinical trial related to COVID-19 compared to men and other racial groups, respectively. Determination of specific reasons for the disparities in trial participation related to COVID-19 in these populations should be further investigated.

Indexed as

COVID-19AdultAmerican Heart AssociationEthnicityFemaleHumansMaleRacial GroupsRegistriesUnited StatesCOVID-19DisparitiesEthnicityRace

Identifiers

PMID35380371
PMCPMC8982302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.