ArticleAnnals of biomedical engineering2022
Patient-Specific Three-Dimensional Ultrasound Derived Computational Modeling of the Mitral Valve.
Article in Annals of biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Systolic Anterior Motion After Mitral Valve Repair: Echocardiographic Prediction, Surgical Prevention and Perioperative Management.Journal of clinical medicine · 2026Review
- A Geometric Feature Tracking Approach for Noninvasive Patient-Specific Estimation of Leaflet Strain from 3D Images of Heart Valves.Annals of biomedical engineering · 2026Article
- A Parametric Model of the Mitral Valve for Finite Element Patient-Specific Simulations.Bioengineering (Basel, Switzerland) · 2026Article
- ValveFit: An analysis-suitable B-spline-based surface fitting framework for patient-specific modeling of tricuspid valves.Computer methods in applied mechanics and engineering · 2026Article
- Article
- Interactive Effects Between Papillary Muscle Approximation and Ring Annuloplasty to Repair Functional Mitral Regurgitation in Enlarged Ventricles.Functional imaging and modeling of the heart : ... International Workshop, FIMH ..., proceedings. FIMH (Conference) · 2025Article
- A Computational Pipeline for Patient-Specific Prediction of the Postoperative Mitral Valve Functional State.Journal of biomechanical engineering · 2023Article
- Computational Modeling of the Subject-Specific Effects of Annuloplasty Ring Sizing on the Mitral Valve to Repair Functional Mitral Regurgitation.Annals of biomedical engineering · 2023Article
- Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral-Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review.Bioengineering (Basel, Switzerland) · 2023Review
- Isolated and combined effects of papillary muscle approximation and mitral annuloplasty in dilated left ventricles.JRSM cardiovascular diseaseArticle
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Authors and funding
4 authors.
Funding
Abstract
Several new techniques to repair the mitral valve affected by functional mitral regurgitation are in development. However, due to the heterogeneity of valve lesions between patients, predicting the outcomes of novel treatment approaches is challenging. We present a patient-specific, 3D ultrasound-derived computational model of the mitral valve for procedure planning, that faithfully mimics the pathological valve dynamics. 3D ultrasound images were obtained in three pigs induced with heart failure and which developed functional mitral regurgitation. For each case, images were segmented, and finite element model of mitral valve was constructed. Annular and papillary muscle dynamics were extracted and imposed as kinematic boundary conditions, and the chordae were pre-strained to induce valve tethering. Valve closure was simulated by applying physiologic transvalvular pressure on the leaflets. Agreement between simulation results and truth datasets was confirmed, with accurate location of regurgitation jets and coaptation defects. Inclusion of kinematic patient-specific boundary conditions was necessary to achieve these results, whereas use of idealized boundary conditions deviated from the truth dataset. Due to the impact of boundary conditions on the model, the effect of repair strategies on valve closure varied as well, indicating that our approach of using patient-specific boundary conditions for mitral valve modeling is valid.
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