ArticleInternational ophthalmology2022
Abnormal quantitative pupillary light responses following COVID-19.
Article in International ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Task-Evoked Pupillary Dynamics Are Altered in Post-COVID Syndrome.Medical sciences (Basel, Switzerland) · 2026Article
- Ocular Symptoms as a Marker of Dysautonomia in Long-COVID Patients: A Cross-Sectional Analysis.Brain sciences · 2026Article
- Evaluation of Stereopsis Performance, Gaze Direction and Pupil Diameter in Post-COVID Syndrome Using Machine Learning.Biomedicines · 2025Article
- Acute primary angle closure during the Omicron outbreak.International journal of ophthalmology · 2024Article
- Comparison of Eye-Tracking Parameters and Brain Oxygen Saturation in Patients with COVID-19 Moderate Pneumonia.Advances in experimental medicine and biology · 2024Article
- Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue Syndrome.Journal of translational medicine · 2023Article
- Virtual reality for assessing stereopsis performance and eye characteristics in Post-COVID.Scientific reports · 2023Article
- Eye movements in patients with post-COVID condition.Biomedical optics express · 2023Article
- Long COVID: major findings, mechanisms and recommendations.Nature reviews. Microbiology · 2023Review
- Long COVID: Clinical Framing, Biomarkers, and Therapeutic Approaches.Journal of personalized medicine · 2023Review
- Smartphone-based evaluation of static balance and mobility in long-lasting COVID-19 patients.Frontiers in neurology · 2023Article
- Pupillographic Analysis of COVID-19 Patients: Early and Late Results After Recovery.Beyoglu eye journal · 2023Article
- Autonomic Dysfunction during Acute SARS-CoV-2 Infection: A Systematic Review.Journal of clinical medicine · 2022Review
- Adie's tonic pupil after COVID-19: a case report and literature review.Romanian journal of ophthalmologyReview
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo characterize alterations in pupillary light reflex responses in subjects following coronavirus disease 2019 (COVID-19), especially those with long-COVID.
methodsThirty-five subjects with previous COVID-19 and 30 healthy control participants were enrolled in this cross-sectional comparative study. An infrared dynamic pupillometry system (MonPack One; Metrovision, France) was used to quantify pupillary light responses. The National Institute for Health and Care Excellence (NICE) long-COVID questionnaire was used to identify persisting symptoms at least 4 weeks after acute COVID-19.
resultsThe median time after the diagnosis of acute COVID-19 was 4.0 (2.0-5.0) months. There was an increase in the latency of pupil contraction (P = 0.001) and a reduction in the duration of pupil contraction (P = 0.039) in post-COVID-19 subjects compared to healthy controls. No significant differences were observed in the initial pupil diameter, amplitude and velocity of pupil contraction or latency, velocity and duration of pupil dilation. Long-COVID was present in 25/35 (71%) subjects and their duration of pupil contraction was reduced compared to subjects without long-COVID (P = 0.009). The NICE long-COVID questionnaire total score (ρ = - 0.507; P = 0.002) and neurological score (ρ = - 0.412; P = 0.014) correlated with the duration of pupil contraction and the total score correlated with the latency of dilation (ρ = - 0.352; P = 0.038).
conclusionDynamic pupillometry reveals significant alterations in contractile pupillary light responses, indicative of parasympathetic dysfunction after COVID-19.
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