Evidence map›Paper›PMID 35380065›Full record

ReviewAnnual review of public health2022

Understanding Health Inequalities Through the Lens of Social Epigenetics.

Chantel L Martin, Lea Ghastine, Evans K Lodge, Radhika Dhingra, Cavin K Ward-Caviness

Open access · hybridAbstract readReview
In one paragraph

Review in Annual review of public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 78 citations in OpenAlex.

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  14. Comprehensive perceptions at the interface between health and environment: Applications models with a citizen science tool.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Article
  15. Article
  16. Review
  17. Epigenetics, Resilience, Protective Factors and Factors Promoting Positive Outcomes: A Scoping Review.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chantel L MartinDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; email: chantelmartin@unc.edu.
Lea GhastineDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; email: chantelmartin@unc.edu.
Evans K LodgeDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; email: chantelmartin@unc.edu.
Radhika DhingraDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Cavin K Ward-CavinessCenter for Public Health and Environmental Assessment, US Environmental Protection Agency, Chapel Hill, North Carolina, USA.
University of North Carolina at Chapel Hill · USEnvironmental Protection Agency · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
Biostatstics for Research in Environmental HealthT32ES007018 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel, Rebecca Fry · 1985 to 2026
$31.3M
POPULATION STUDIEST32HD007168 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ELIZABETH A FRANKENBERG · 1985 to 2026
$13.8M
Epigenetic mechanisms of prenatal environmental stressors and offspring obesity riskR00MD012808 · NIMHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MARTIN, CHANTEL L. · 2020 to 2022
$693k
Socioenvironmental Causes of Elevated Toxic Metal Levels and Epigenetic AgingF30ES032302 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LODGE, EVANS · 2021 to 2023
$124k
Intramural EPA EPA999999NICHD NIH HHS T32 HD007168NIEHS NIH HHS F30 ES032302NIEHS NIH HHS P30 ES010126NIEHS NIH HHS T32 ES007018NIMHD NIH HHS R00 MD012808
6 · The paper itself

Abstract

Longstanding racial/ethnic inequalities in morbidity and mortality persist in the United States. Although the determinants of health inequalities are complex, social and structural factors produced by inequitable and racialized systems are recognized as contributing sources. Social epigenetics is an emerging area of research that aims to uncover biological pathways through which social experiences affect health outcomes. A growing body of literature links adverse social exposures to epigenetic mechanisms, namely DNA methylation, offering a plausible pathway through which health inequalities may arise. This review provides an overview of social epigenetics and highlights existing literature linking social exposures-i.e., psychosocial stressors, racism, discrimination, socioeconomic position, and neighborhood social environment-to DNA methylation in humans. We conclude with a discussion of social epigenetics as a mechanistic link to health inequalities and provide suggestions for future social epigenetics research on health inequalities.

Indexed as

EpigenomicsHealth Status DisparitiesDNA MethylationEpigenesis, GeneticHumansRacial GroupsUnited StatesDNA methylationepigenetic mechanismshealth inequalitiespsychosocial stressorsracismsocioeconomic disadvantage

Identifiers

PMID35380065
PMCPMC9584166
OpenAlexW4225463360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.