Evidence map›Paper›PMID 35380030›Full record

ArticleJournal of biomedical optics2022

Scalable and accessible personalized photodynamic therapy optimization with FullMonte and PDT-SPACE.

Shuran Wang, Xiao Ying Dai, Shengxiang Ji, Tina Saeidi, Fynn Schwiegelshohn, Abdul-Amir Yassine, Lothar Lilge, Vaughn Betz

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  16. A Monte Carlo simulation for Moving Light Source in Intracavity PDT.Proceedings of SPIE--the International Society for Optical Engineering
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuran WangUniversity of Toronto, Edward S. Rogers Sr. Department of Electrical and Computer Engineering, Toron, Canada.
Xiao Ying DaiUniversity of Toronto, Edward S. Rogers Sr. Department of Electrical and Computer Engineering, Toron, Canada.
Shengxiang JiUniversity of Toronto, Edward S. Rogers Sr. Department of Electrical and Computer Engineering, Toron, Canada.
Tina SaeidiUniversity of Toronto, Department of Medical Biophysics, Toronto, Ontario, Canada.
Fynn SchwiegelshohnUniversity of Toronto, Edward S. Rogers Sr. Department of Electrical and Computer Engineering, Toron, Canada.
Abdul-Amir YassineUniversity of Toronto, Edward S. Rogers Sr. Department of Electrical and Computer Engineering, Toron, Canada.
Lothar LilgeUniversity of Toronto, Department of Medical Biophysics, Toronto, Ontario, Canada.
Vaughn BetzUniversity of Toronto, Edward S. Rogers Sr. Department of Electrical and Computer Engineering, Toron, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

significanceOpen-source software packages have been extensively used in the past three decades in medical imaging and diagnostics, aiming to study the feasibility of the application ex vivo. Unfortunately, most of the existing open-source tools require some software engineering background to install the prerequisite libraries, choose a suitable computational platform, and combine several software tools to address different applications.

aimTo facilitate the use of open-source software in medical applications, enabling computational studies of treatment outcomes prior to the complex in-vivo setting. APPROACH: FullMonteWeb, an open-source, user-friendly web-based software with a graphical user interface for interstitial photodynamic therapy (iPDT) modeling, visualization, and optimization, is introduced. The software can perform Monte Carlo simulations of light propagation in biological tissues, along with iPDT plan optimization. FullMonteWeb installs and runs the required software and libraries on Amazon Web Services (AWS), allowing scalable computing without complex set up.

resultsFullMonteWeb allows simulation of large and small problems on the most appropriate compute hardware, enabling cost improvements of 10  ×   versus always running on a single platform. Case studies in optical property estimation and diffuser placement optimization highlight FullMonteWeb's versatility.

conclusionThe FullMonte open source suite enables easier and more cost-effective in-silico studies for iPDT.

Indexed as

PhotochemotherapyComputer SimulationMonte Carlo MethodSoftwarebiophotonicsMonte-Carloopen-sourceoptimizationphotodynamic therapy

Identifiers

PMID35380030
PMCPMC8978262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.