Evidence map›Paper›PMID 35379992›Full record

ArticleNature genetics2022

New insights into the genetic etiology of Alzheimer's disease and related dementias.

Céline Bellenguez, Fahri Küçükali, Iris E Jansen, Luca Kleineidam, Sonia Moreno-Grau, Najaf Amin, Adam C Naj, Rafael Campos-Martin, Benjamin Grenier-Boley, Victor Andrade and 402 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01315639 (Plasma Abeta Peptides and the Risk of Alzheimer's Disease. Diagnostic Performance and Predictive and Prognostic Values of Measurements of Plasma Amyloid Peptides Concentrations for the Diagnosis of Alzheimer's Disease), which is not on this map. Cited by 1,660 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,660citing papers in PubMed, 4 pooled it
422.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01315639 nacompletednot on this map

Plasma Abeta Peptides and the Risk of Alzheimer's Disease. Diagnostic Performance and Predictive and Prognostic Values of Measurements of Plasma Amyloid Peptides Concentrations for the Diagnosis of Alzheimer's Disease

TypeinterventionalSponsorAssistance Publique - Hôpitaux de ParisRan2010 to 2018Enrolled1,067ConditionsAlzheimer's Disease, Mild Cognitive ImpairmentArmsbiomarkers, MRI and CSF
3 · Its place in the literature

Who cites it

1,660 citing papers in PubMed, 4 syntheses or guidelines pooled it, 2,354 citations in OpenAlex.

  1. Pooled it
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  4. Pooled it
  5. Article
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  7. miR-214-3p and NCKAP1: A microglial functional dimension of Alzheimer's progression.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  8. Observational
  9. Article
  10. Targeting Microglial Transcriptional Reprogramming as a Therapy Strategy for Alzheimer's Disease.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  11. Article
  12. Article
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  14. Review
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  18. Article
  19. Clusterin is enriched in plaque-associated astrocytes and localizes to synapses in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  20. Article

1,600 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

412 authors at 20 institutions in 26 countries.

Céline Bellenguez *Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France. celine.bellenguez@pasteur-lille.fr.ORCID http://orcid.org/0000-0002-1240-7874
Fahri Küçükali *Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-3835-9639
Iris E Jansen *Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
Luca Kleineidam *Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.
Sonia Moreno-Grau *Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Najaf Amin *Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-8944-1771
Adam C Naj *Department of Biostatistics, Epidemiology, and Informatics, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Rafael Campos-Martin *Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.
Benjamin Grenier-BoleyUniversité de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France.
Victor AndradeDepartment of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.
Peter A HolmansMRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0003-0870-9412
Anne BolandCEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France.
Vincent DamotteUniversité de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France.
Sven J van der LeeAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0003-1606-8643
Marcos R CostaUniversité de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France.ORCID http://orcid.org/0000-0002-4928-2163
Teemu KuulasmaaInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-1795-7314
Qiong YangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3658-1375
Itziar de RojasResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0002-2148-381X
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3409-1110
Amber YaqubDepartment of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-3579-8054
Ivana ProkicDepartment of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-0370-1473
Julien ChapuisUniversité de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France.ORCID http://orcid.org/0000-0002-5802-2857
Shahzad AhmadDepartment of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-8658-3790
Vilmantas GiedraitisDepartment of Public Health and Carins Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-3423-2021
Dag AarslandCentre of Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.
Pablo Garcia-GonzalezResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0003-0125-5403
Carla AbdelnourResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Emilio Alarcón-MartínResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Daniel AlcoleaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-3819-3245
Montserrat AlegretResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Ignacio AlvarezFundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital MútuaTerrassa, Terrassa, Spain.ORCID http://orcid.org/0000-0002-8537-3935
Victoria ÁlvarezLaboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain.
Nicola J ArmstrongCentre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Anthoula TsolakiFirst Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID http://orcid.org/0000-0002-5563-7776
Carmen AntúnezUnidad de Demencias, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
Ildebrando AppollonioSchool of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.
Marina ArcaroFondazione IRCCS Ca'Granda, Ospedale Policlinico, Milan, Italy.
Silvana ArchettiDepartment of Laboratory Diagnostics, III Laboratory of Analysis, Brescia Hospital, Brescia, Italy.
Alfonso Arias PastorUnitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.
Beatrice ArosioDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Lavinia AthanasiuNORMENT Centre, University of Oslo, Oslo, Norway.
Henri BaillyEA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France.
Nerisa BanajLaboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
Miquel BaqueroServei de Neurologia, Hospital Universitari i Politècnic La Fe, Valencia, Spain.ORCID http://orcid.org/0000-0002-6861-1831
Sandra BarralTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
Alexa BeiserInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Ana Belén PastorCIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain.ORCID http://orcid.org/0000-0001-9637-4688
Jennifer E BelowVanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
Penelope BenchekCleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.
Luisa BenussiMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Claudine BerrNeuropsychiatry: Epidemiological and Clinical Research, PSNREC, Université de Montpellier, INSERM U1061, Montpellier, France.ORCID http://orcid.org/0000-0001-5254-7655
Céline BesseCEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France.
Valentina BessiDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.ORCID http://orcid.org/0000-0002-6176-3584
Giuliano BinettiMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Alessandra BizarroGeriatrics Unit, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
Rafael BlesaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Mercè BoadaResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0003-2617-3009
Eric BoerwinkleHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Barbara BorroniCentre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Silvia BoschiDepartment of Neuroscience "Rita Levi Montalcini", University of Torino, Torino, Italy.
Paola BossùExperimental Neuro-psychobiology Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.ORCID http://orcid.org/0000-0002-1432-0078
Geir BråthenDepartment of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway.ORCID http://orcid.org/0000-0003-3224-7983
Jan BresslerHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0001-6578-4772
Catherine BresnerMRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0003-2673-9762
Henry BrodatyCentre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0001-9487-6617
Keeley J BrookesBiosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK.ORCID http://orcid.org/0000-0003-2427-2513
Luis Ignacio BruscoCentro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A., Buenos Aires, Argentina.
Dolores Buiza-RuedaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Katharina BûrgerInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany.
Vanessa BurholtFaculty of Medical & Health Sciences, University of Auckland, Auckland, New Zealand.ORCID http://orcid.org/0000-0002-6789-127X
William S BushDepartment of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-9729-6519
Miguel CaleroResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0001-5366-3324
Laura B CantwellDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Geneviève CheneINSERM, Bordeaux Population Health Research Center, UMR 1219, ISPED, CIC 1401-EC, Université de Bordeaux, Bordeaux, France.
Jaeyoon ChungMedicine Biomedical Genetics Boston University School of Medicine, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6431-9454
Michael L CuccaroDr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA.
Ángel CarracedoGrupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Roberta CecchettiInstitute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Laura Cervera-CarlesCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0003-2286-200X
Camille CharbonnierDepartment of Genetics and CNR-MAJ, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France.
Hung-Hsin ChenDivision of Genetic Medicine, Vanderbilt University, Nashville, TN, USA.
Caterina ChillottiUnit of Clinical Pharmacology, University Hospital of Cagliari, Cagliari, Italy.
Simona CicconeGeriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
Jurgen A H R ClaassenRadboudumc Alzheimer Center, Department of Geriatrics, Radboud University Medical Center, Nijmegen, the Netherlands.
Christopher ClarkInstitute for Regenerative Medicine, University of Zürich, Schlieren, Switzerland.
Elisa ContiSchool of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.
Anaïs Corma-GómezUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.
Emanuele CostantiniDepartment of Neuroscience, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0002-1096-8221
Carlo CustoderoUniversity of Bari, "A. Moro", Bary, Italy.
Delphine DaianCEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France.
Maria Carolina DalmassoDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.ORCID http://orcid.org/0000-0002-4901-9955
Antonio DanieleDepartment of Neuroscience, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Efthimios DardiotisSchool of Medicine, University of Thessaly, Larissa, Greece.
Jean-François DartiguesBordeaux Population Health Research Center, University Bordeaux, INSERM, Bordeaux, France.
Peter Paul de DeynDepartment of Neurology, University Medical Center Groningen, Groningen, the Netherlands.
Katia de Paiva LopesRonald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-0240-0126
Lot D de WitteDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-7235-9958
Stéphanie DebetteBordeaux Population Health Research Center, University Bordeaux, INSERM, Bordeaux, France.ORCID http://orcid.org/0000-0001-8675-7968
Jürgen DeckertDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany.
Teodoro Del SerCIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain.ORCID http://orcid.org/0000-0001-9806-7083
Nicola DenningUKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK.
Anita DeStefanoInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Martin DichgansInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany.ORCID http://orcid.org/0000-0002-0654-387X
Janine Diehl-SchmidKlinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany.ORCID http://orcid.org/0000-0002-7745-1382
Mónica Diez-FairenFundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital MútuaTerrassa, Terrassa, Spain.ORCID http://orcid.org/0000-0003-1882-0309
Paolo Dionigi RossiGeriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
Srdjan DjurovicNORMENT Centre, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-8140-8061
Emmanuelle DuronEA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France.
Emrah DüzelInstitute of Cognitive Neurology and Dementia Research (IKND), Otto-Von-Guericke University, Magdeburg, Germany.
Carole DufouilINSERM, Bordeaux Population Health Research Center, UMR 1219, ISPED, CIC 1401-EC, Université de Bordeaux, Bordeaux, France.ORCID http://orcid.org/0000-0003-2442-4476
Gudny EiriksdottirIcelandic Heart Association, Kopovagur, Iceland.
Sebastiaan EngelborghsCenter for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Valentina Escott-PriceDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-1784-5483
Ana EspinosaResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Michael EwersInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany.ORCID http://orcid.org/0000-0001-5231-1714
Kelley M FaberDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.
Tagliavini FabrizioFondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy.ORCID http://orcid.org/0000-0003-1039-7315
Sune Fallgaard NielsenDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, Denmark.
David W FardoSanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, KY, USA.
Lucia FarottiCentre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy.
Chiara FenoglioUniversity of Milan, Milan, Italy.
Marta Fernández-FuertesUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.
Raffaele FerrariLaboratory of Neurogenetics, Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, TX, USA.
Catarina B FerreiraFaculty of Medicine, University of Lisbon, Lisbon, Portugal.
Evelyn FerriGeriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
Bertrand FinCEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France.
Peter FischerDepartment of Psychiatry, Social Medicine Center East- Donauspital, Vienna, Austria.
Tormod FladbyInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-9984-9797
Klaus FließbachDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.
Bernard FongangGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.
Myriam FornageDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0003-0677-8158
Juan ForteaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Tatiana M ForoudDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.
Silvia FostinelliMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Nick C FoxDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0002-6660-657X
Emlio Franco-MacíasUnidad de Demencias, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
María J BullidoCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-6477-1117
Ana Frank-GarcíaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Lutz FroelichDepartment of Geriatric Psychiatry, Central Institute for Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-1494-0813
Brian Fulton-HowardDepartment of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Daniela GalimbertiFondazione IRCCS Ca'Granda, Ospedale Policlinico, Milan, Italy.ORCID http://orcid.org/0000-0002-9284-5953
Jose Maria García-AlbercaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0003-2951-6644
Pablo García-GonzálezResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Sebastian Garcia-MadronaHospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain.
Guillermo Garcia-RibasHospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain.
Roberta GhidoniMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Ina GieglingDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Giaccone GiorgioFondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy.
Alison M GoateDepartment of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-0576-2472
Oliver GoldhardtKlinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany.
Duber Gomez-FonsecaDepartment of Biostatistics, Epidemiology, and Informatics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Antonio González-PérezCAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain.ORCID http://orcid.org/0000-0001-9771-5982
Caroline GraffCenter for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.
Giulia GrandeAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Emma GreenInstitute of Public Health, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-8687-5590
Timo GrimmerKlinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany.
Edna GrünblattDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-8505-7265
Michelle GruninDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Vilmundur GudnasonIcelandic Heart Association, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-5696-0084
Tamar Guetta-BaranesHuman Genetics, School of Life Sciences, Life Sciences Building, University Park, University of Nottingham, Nottingham, UK.
Annakaisa HaapasaloAI Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0003-0959-2957
Georgios HadjigeorgiouDepartment of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.
Jonathan L HainesDepartment of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Kara L Hamilton-NelsonThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Harald HampelGRC 21, Alzheimer Precision Medicine Initiative (APMI), Sorbonne University, AP-HP, Pitié-Salpêtrière Hospital, Paris, France.
Olivier HanonEA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France.
John HardyReta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
Annette M HartmannDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Lucrezia HausnerDepartment of Geriatric Psychiatry, Central Institute for Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany.
Janet HarwoodMRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0002-3225-0069
Stefanie Heilmann-HeimbachInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-1057-465X
Seppo HelisalmiInstitute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.
Michael T HenekaDepartment of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.
Isabel HernándezResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Martin J HerrmannDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany.ORCID http://orcid.org/0000-0001-9970-2122
Per HoffmannInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Clive HolmesClinical and Experimental Science, Faculty of Medicine, University of Southampton, Southampton, UK.
Henne HolstegeAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-7688-3087
Raquel Huerto VilasUnitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.
Marc HulsmanAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
Jack HumphreyRonald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Geert Jan BiesselsDepartment of Neurology, UMC Utrecht Brain Center, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0001-6862-2496
Xueqiu JianGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.ORCID http://orcid.org/0000-0002-0313-6494
Charlotte JohanssonCenter for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-5351-1950
Gyungah R JunMedicine Biomedical Genetics Boston University School of Medicine, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3230-8697
Yuriko KastumataBiostatistics, University of Kentucky College of Public Health, Lexington, KY, USA.ORCID http://orcid.org/0000-0002-0188-8094
John KauweDepartment of Biology, Brigham Young University, Provo, UT, USA.
Patrick G KehoeTranslational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-7542-1139
Lena KilanderDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Anne Kinhult StåhlbomCenter for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.
Miia KivipeltoDivision of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.
Anne KoivistoInstitute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.
Johannes KornhuberDepartment of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID http://orcid.org/0000-0002-8096-3987
Mary H KosmidisLaboratory of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID http://orcid.org/0000-0001-8790-1220
Walter A KukullDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Pavel P KuksaDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Brian W KunkleDepartment of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.
Amanda B KuzmaDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Carmen LageCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0003-1703-121X
Erika J LaukkaAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Lenore LaunerLaboratory of Epidemiology, Demography, and Biometry, National Institute of Aging, The National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-3238-7612
Alessandra LauriaGeriatrics Unit, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
Chien-Yueh LeeDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-4304-974X
Jenni LehtisaloInstitute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.
Ondrej LerchMemory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Praha, Czechia.
Alberto LleóCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-2568-5478
William LongstrethDepartments of Neurology and Epidemiology, University of Washington, Seattle, WA, USA.
Oscar LopezFramingham Heart Study, Framingham, MA, USA.ORCID http://orcid.org/0000-0002-8546-8256
Adolfo Lopez de MunainCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-9509-4032
Seth LoveTranslational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Malin LöwemarkDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Lauren LuckcuckMRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.
Kathryn L LunettaInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-9268-810X
Yiyi MaSection Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-3609-8877
Juan MacíasUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.
Catherine A MacLeodSchool of Health Sciences, Bangor University, Bangor, UK.ORCID http://orcid.org/0000-0002-9314-7380
Wolfgang MaierDepartment of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.
Francesca MangialascheDivision of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.
Marco SpallazziUnit of Neurology, University of Parma and AOU, Parma, Italy.
Marta MarquiéResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0002-0660-0950
Rachel MarshallMRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.
Eden R MartinThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Angel Martín MontesCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-1694-786X
Carmen Martínez RodríguezServicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain.
Carlo MasulloInstitute of Neurology, Catholic University of the Sacred Heart, Rome, Italy.
Richard MayeuxTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
Simon MeadMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.ORCID http://orcid.org/0000-0002-4326-1468
Patrizia MecocciInstitute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Miguel MedinaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-7016-5340
Alun MeggyUKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK.
Shima MehrabianClinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria.
Silvia MendozaAlzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain.
Manuel Menéndez-GonzálezServicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain.ORCID http://orcid.org/0000-0002-5218-0774
Pablo MirCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Susanne MoebusInstitute for Urban Public Health, University Hospital of University Duisburg-Essen, Essen, Germany.
Merel MolDepartment of Neurology, Erasmus MC, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-2533-2530
Laura Molina-PorcelNeurological Tissue Bank of the Biobanc-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
Laura MontrrealResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Laura MorelliLaboratory of Brain Aging and Neurodegeneration, FIL-CONICET, Buenos Aires, Argentina.
Fermin MorenoCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Kevin MorganHuman Genetics, School of Life Sciences, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0002-8217-2396
Thomas MosleyMemory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA.
Markus M NöthenInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-8770-2464
Carolina MuchnikCentro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A., Buenos Aires, Argentina.ORCID http://orcid.org/0000-0002-1542-3706
Shubhabrata MukherjeeDepartment of Medicine, University of Washington, Seattle, WA, USA.
Benedetta NacmiasDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.ORCID http://orcid.org/0000-0001-9338-9040
Tiia NganduPublic Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Gael NicolasDepartment of Genetics and CNR-MAJ, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France.ORCID http://orcid.org/0000-0001-9391-7800
Børge G NordestgaardDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, Denmark.ORCID http://orcid.org/0000-0002-1954-7220
Robert OlasoCEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France.
Adelina OrellanaResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Michela OrsiniDepartment of Neuroscience, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Gemma OrtegaResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Alessandro PadovaniHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Caffarra PaoloDIMEC, University of Parma, Parma, Italy.
Goran PapenbergAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Lucilla ParnettiCentre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy.
Florence PasquierResources and Research Memory Center (MRRC) of Distalz, LicendUniversity of Lille, INSERM, CHU Lille, UMR1172, Lille, France.ORCID http://orcid.org/0000-0001-9880-9788
Pau PastorFundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital MútuaTerrassa, Terrassa, Spain.ORCID http://orcid.org/0000-0002-7493-8777
Gina PelosoInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-5355-8636
Alba Pérez-CordónResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0002-6028-0791
Jordi Pérez-TurCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-9111-1712
Pierre PericardUS 41-UMS 2014-PLBS, bilille, Université de Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Lille, France.ORCID http://orcid.org/0000-0001-8167-6448
Oliver PetersInstitute of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Yolande A L PijnenburgAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
Juan A PinedaUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.ORCID http://orcid.org/0000-0002-3751-0296
Gerard Piñol-RipollUnitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.
Claudia PisanuDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.ORCID http://orcid.org/0000-0002-9151-4319
Thomas PolakDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany.
Julius PoppCHUV, Old Age Psychiatry, Department of Psychiatry, Lausanne, Switzerland.
Danielle PosthumaDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije University, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-7582-2365
Josef PrillerGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
Raquel PuertaResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0002-1191-5893
Olivier QuenezDepartment of Genetics and CNR-MAJ, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France.ORCID http://orcid.org/0000-0002-8273-8505
Inés QuintelaGrupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Jesper Qvist ThomassenDepartment of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-3484-9531
Alberto RábanoCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Innocenzo RaineroCentre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Farid RajabliThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Inez RamakersDepartment of Psychiatry & Neuropsychologie, Maastricht University, Alzheimer Center Limburg, Maastricht, the Netherlands.
Luis M RealUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.ORCID http://orcid.org/0000-0003-4932-7429
Marcel J T ReindersDelft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands.ORCID http://orcid.org/0000-0002-1148-1562
Christiane ReitzGertrude H. Sergievsky Center, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0001-8757-7889
Dolly Reyes-DumeyerDepartment of Neurology, Columbia University, New York, NY, USA.
Perry RidgeBioinformatics, College of Life Sciences, Brigham Young University, Provo, UT, USA.
Steffi Riedel-HellerInstitute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0003-4321-6090
Peter RiedererCenter of Mental Health, Clinic and Policlinic of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Wuerzburg, Germany.
Natalia RobertoResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Eloy Rodriguez-RodriguezCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0001-7742-677X
Arvid RongveDepartment of Research and Innovation, Helse Fonna, Haugesund Hospital, Haugesund, Norway.ORCID http://orcid.org/0000-0002-0476-4134
Irene Rosas AllendeLaboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain.
Maitée Rosende-RocaResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Jose Luis RoyoDepartamento de Especialidades Quirúrgicas, Bioquímicas e Inmunología, School of Medicine, University of Málaga, Málaga, Spain.
Elisa RubinoDepartment of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Torino, Italy.
Dan RujescuDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
María Eugenia SáezCAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain.ORCID http://orcid.org/0000-0001-9299-2534
Paraskevi SakkaAthens Association of Alzheimer's Disease and Related Disorders, Athens, Greece.
Ingvild SaltvedtDepartment of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway.ORCID http://orcid.org/0000-0002-7897-9808
Ángela SanabriaResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
María Bernal Sánchez-ArjonaUnidad de Demencias, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
Florentino Sanchez-GarciaDepartment of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Las Palmas, Spain.
Pascual Sánchez JuanCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-6081-8037
Raquel Sánchez-ValleNeurology Department-Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain.
Sigrid B SandoExperimental Neuro-psychobiology Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
Chloé SarnowskiHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0002-6090-7099
Claudia L SatizabalDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1115-4430
Michela ScamosciInstitute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Nikolaos ScarmeasTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
Elio ScarpiniFondazione IRCCS Ca'Granda, Ospedale Policlinico, Milan, Italy.
Philip ScheltensAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
Norbert ScherbaumLVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Martin SchererDepartment of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Matthias SchmidGerman Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.
Anja SchneiderDepartment of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.
Jonathan M SchottDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0003-2059-024X
Geir SelbækInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-6511-8219
Davide SeripaLaboratory for Advanced Hematological Diagnostics, Department of Hematology and Stem Cell Transplant, Vito Fazzi Hospital, Lecce, Italy.
Manuel SerranoCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, CIBERDEM, Hospital Clínico San Carlos, Madrid, Spain.
Jin ShaDepartment of Biostatistics, Epidemiology, and Informatics, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Alexey A ShadrinNORMENT Centre, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-7467-250X
Olivia SkrobotTranslational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Susan SliferThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Gijsje J L SnijdersDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hilkka SoininenInstitute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.ORCID http://orcid.org/0000-0002-2785-9937
Vincenzo SolfrizziUniversity of Bari, "A. Moro", Bary, Italy.ORCID http://orcid.org/0000-0002-8524-0315
Alina SolomonInstitute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.
Yeunjoo SongDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-7452-3731
Sandro SorbiDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Oscar Sotolongo-GrauResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0002-9679-0670
Gianfranco SpallettaLaboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.ORCID http://orcid.org/0000-0002-7432-4249
Annika SpottkeGerman Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.
Alessio SquassinaDepartment of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy.ORCID http://orcid.org/0000-0001-7415-7607
Eystein StordalDepartment of Psychiatry, Namsos Hospital, Namsos, Norway.ORCID http://orcid.org/0000-0002-2443-7923
Juan Pablo TartanResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Lluís TárragaResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Niccolo TesíAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
Anbupalam ThalamuthuCentre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Tegos ThomasFirst Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Giuseppe TostoTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0001-7075-8245
Latchezar TraykovClinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria.
Lucio TremolizzoSchool of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.
Anne Tybjærg-HansenDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Andre UitterlindenDepartment of Internal Medicine and Biostatistics, Erasmus MC, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-7276-3387
Abbe UllgrenCenter for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.
Ingun UlsteinDepartment of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.
Sergi ValeroResearch Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Otto ValladaresDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8055-2187
Christine Van BroeckhovenComplex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.ORCID http://orcid.org/0000-0003-0183-7665
Jeffery VanceDr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA.
Badri N VardarajanTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
Aad van der LugtDepartment of Neurology, ErasmusMC, Rotterdam, the Netherlands.
Jasper Van DongenComplex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
Jeroen van RooijDepartment of Neurology, Erasmus MC, Rotterdam, the Netherlands.
John van SwietenDepartment of Neurology, Erasmus MC, Rotterdam, the Netherlands.
Rik VandenbergheLaboratory for Cognitive Neurology, Department of Neurosciences, University of Leuven, Leuven, Belgium.
Frans VerheyDepartment of Psychiatry & Neuropsychologie, Maastricht University, Alzheimer Center Limburg, Maastricht, the Netherlands.
Jean-Sébastien VidalEA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France.ORCID http://orcid.org/0000-0001-6770-0720
Jonathan VogelgsangDepartment of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.ORCID http://orcid.org/0000-0001-9326-8193
Martin VyhnalekMemory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Praha, Czechia.
Michael WagnerDepartment of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-2589-6440
David WallonDepartment of Neurology and CNR-MAJ, F 76000, Normandy Center for Genomic and Personalized Medicine, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France.ORCID http://orcid.org/0000-0002-2634-7198
Li-San WangDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Ruiqi WangInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Leonie WeinholdInstitute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany.
Jens WiltfangDepartment of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.ORCID http://orcid.org/0000-0003-1492-5330
Gill WindleSchool of Health Sciences, Bangor University, Bangor, UK.
Bob WoodsSchool of Health Sciences, Bangor University, Bangor, UK.ORCID http://orcid.org/0000-0002-6781-651X
Mary YannakouliaDepartment of Nutrition and Diatetics, Harokopio University, Athens, Greece.ORCID http://orcid.org/0000-0003-2171-7337
Habil ZareGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.ORCID http://orcid.org/0000-0001-5902-6238
Yi ZhaoDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Xiaoling ZhangDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8237-1857
Congcong ZhuDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
Miren ZulaicaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
EADB
GR@ACE
DEGESCO
EADI
GERAD
Demgene
FinnGen
ADGC
CHARGE
Lindsay A FarrerInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0001-5533-4225
Bruce M PsatyFramingham Heart Study, Framingham, MA, USA.ORCID http://orcid.org/0000-0002-7278-2190
Mohsen GhanbariDepartment of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-9476-7143
Towfique RajRonald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-9355-5704
Perminder SachdevCentre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-9595-3220
Karen MatherCentre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0003-4143-8941
Frank JessenDepartment of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.
M Arfan IkramDepartment of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Alexandre de MendonçaFaculty of Medicine, University of Lisbon, Lisbon, Portugal.
Jakub HortIntramural Research Program/National Institute on Aging/National Institutes of Health, Bethesda, MD, USA.
Magda TsolakiFirst Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID http://orcid.org/0000-0002-2072-8010
Margaret A Pericak-VanceAI Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0001-7283-8804
Philippe AmouyelUniversité de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France.ORCID http://orcid.org/0000-0001-9088-234X
Julie WilliamsMRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0002-4069-0259
Ruth Frikke-SchmidtDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4084-5027
Jordi ClarimonCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Jean-François DeleuzeCEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France.
Giacomina RossiFondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy.
Sudha SeshadriDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6135-2622
Ole A AndreassenNORMENT Centre, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-4461-3568
Martin IngelssonDepartment of Public Health and Carins Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
Mikko Hiltunen *Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
Kristel Sleegers *Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-0283-2332
Gerard D Schellenberg *Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Cornelia M van Duijn *Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-2374-9204
Rebecca Sims *MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0002-3885-1199
Wiesje M van der Flier *Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-8766-6224
Agustín Ruiz *Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Alfredo Ramirez *Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-4991-763X
Jean-Charles Lambert *Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France. Jean-Charles.Lambert@pasteur-lille.fr.ORCID http://orcid.org/0000-0003-0829-7817
Instituto de Salud Carlos III · ESUniversity of Helsinki · FIHospital District of Helsinki and Uusimaa · FIBoston University · USCardiff University · GBFundació ACE · ESUniversity of Pennsylvania · USInserm · FRUniversity of Washington · USErasmus MC · NLFinnish Institute for Health and Welfare · FIUniversity of Eastern Finland · FIUniversity of Miami · USAbbVie (United States) · USGerman Center for Neurodegenerative Diseases · DEPfizer (United States) · USSanofi (France) · FRNorthern Ostrobothnia Hospital District · FIThe University of Texas Health Science Center at San Antonio · USCase Western Reserve University · US

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI Paul S. Aisen · 2016 to 2026
$226.7M
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
Project-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5M
THE FRAMINGHAM HEART STUDYN01HC25195 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2007 to 2014
$83.8M
Vascular Structure and Function in Cognitive AgingP01AG003949 · NIA · YESHIVA UNIVERSITY · PI Charles B Hall · 1985 to 2026
$73.9M
NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Alzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4M
THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 1985 to 2019
$57.2M
VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 1985 to 2018
$55.4M
Department of HealthHoward Hughes Medical InstituteMedical Research Council G0300429Medical Research Council G0601022Medical Research Council G0701075Medical Research Council G0801418/1Medical Research Council G0901254Medical Research Council G0902227Medical Research Council G9901400Medical Research Council MC_PC_17112Medical Research Council MR/K013041/1Medical Research Council MR/L010305/1Medical Research Council MR/L023784/1Medical Research Council MR/L023784/2Medical Research Council MR/L501517/1Medical Research Council MR/L501529/1Medical Research Council MR/N029402/1Medical Research Council MR/R024804/1Medical Research Council MR/T04604X/1Medical Research Council UKDRI-2002Motor Neurone Disease Association ALCHALABI-DOBSON/APR14/829-791NCATS NIH HHS UL1 TR001445NCRR NIH HHS KL2 RR024151NCRR NIH HHS UL1 RR029893NEI NIH HHS T32 EY007157NHGRI NIH HHS U01 HG004610NHGRI NIH HHS U01 HG006375NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS N01HC25195NHLBI NIH HHS N01HC55222NHLBI NIH HHS N01HC85079NHLBI NIH HHS N01HC85080NHLBI NIH HHS N01HC85081NHLBI NIH HHS N01HC85082NHLBI NIH HHS N01HC85083NHLBI NIH HHS N01HC85086NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS F99 AG073565NIA NIH HHS K08 AG065463NIA NIH HHS K99 AG066849NIA NIH HHS P01 AG002219NIA NIH HHS P01 AG003949NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG010491NIA NIH HHS P01 AG017216NIA NIH HHS P01 AG017586NIA NIH HHS P01 AG019724NIA NIH HHS P01 AG026276NIA NIH HHS P01 AG066597NIA NIH HHS P30 AG008017NIA NIH HHS P30 AG008051NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG012300NIA NIH HHS P30 AG013846NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG028377NIA NIH HHS P30 AG028383NIA NIH HHS P30 AG053760NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG062715NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066462NIA NIH HHS P30 AG066509NIA NIH HHS P30 AG066511NIA NIH HHS P30 AG066512NIA NIH HHS P30 AG066514NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072972NIA NIH HHS P30 AG072976NIA NIH HHS P30 AG072977NIA NIH HHS P30 AG072979NIA NIH HHS P30 AG072980NIA NIH HHS P50 AG005131NIA NIH HHS P50 AG005133NIA NIH HHS P50 AG005134NIA NIH HHS P50 AG005136NIA NIH HHS P50 AG005138NIA NIH HHS P50 AG005142NIA NIH HHS P50 AG005144NIA NIH HHS P50 AG005146NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG008702NIA NIH HHS P50 AG016570NIA NIH HHS P50 AG016573NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG016582NIA NIH HHS P50 AG023501NIA NIH HHS P50 AG025688NIA NIH HHS P50 AG025711NIA NIH HHS P50 AG033514NIA NIH HHS R01 AG009029NIA NIH HHS R01 AG009956NIA NIH HHS R01 AG011101NIA NIH HHS R01 AG012101NIA NIH HHS R01 AG013616NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017173NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG018023NIA NIH HHS R01 AG019085NIA NIH HHS R01 AG019757NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG020688NIA NIH HHS R01 AG021547NIA NIH HHS R01 AG022018NIA NIH HHS R01 AG022374NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG023651NIA NIH HHS R01 AG025259NIA NIH HHS R01 AG026916NIA NIH HHS R01 AG027944NIA NIH HHS R01 AG028786NIA NIH HHS R01 AG030146NIA NIH HHS R01 AG030653NIA NIH HHS R01 AG031581NIA NIH HHS R01 AG032990NIA NIH HHS R01 AG033040NIA NIH HHS R01 AG033193NIA NIH HHS R01 AG035137NIA NIH HHS R01 AG036042NIA NIH HHS R01 AG036836NIA NIH HHS R01 AG037212NIA NIH HHS R01 AG037985NIA NIH HHS R01 AG041232NIA NIH HHS R01 AG041718NIA NIH HHS R01 AG041797NIA NIH HHS R01 AG042437NIA NIH HHS R01 AG048015NIA NIH HHS R01 AG048927NIA NIH HHS R01 AG049607NIA NIH HHS R01 AG054005NIA NIH HHS R01 AG054076NIA NIH HHS R01 AG062622NIA NIH HHS R21 AG063130NIA NIH HHS R37 AG015473NIA NIH HHS R56 AG055824NIA NIH HHS R56 AG057191NIA NIH HHS RC2 AG036502NIA NIH HHS RC2 AG036528NIA NIH HHS RC2 AG036547NIA NIH HHS RC2 AG036650NIA NIH HHS RF1 AG057473NIA NIH HHS RF1 AG057519NIA NIH HHS RF1 AG059319NIA NIH HHS RF1 AG059421NIA NIH HHS RF1 AG061351NIA NIH HHS RF1 AG061872NIA NIH HHS U01 AG006781NIA NIH HHS U01 AG006786NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG032984NIA NIH HHS U01 AG046139NIA NIH HHS U01 AG046152NIA NIH HHS U01 AG046161NIA NIH HHS U01 AG049505NIA NIH HHS U01 AG052409NIA NIH HHS U01 AG058589NIA NIH HHS U01 AG058654NIA NIH HHS U01 AG061356NIA NIH HHS U01 AG068880NIA NIH HHS U19 AG024904NIA NIH HHS U19 AG062418NIA NIH HHS U19 AG068753NIA NIH HHS U24 AG021886NIA NIH HHS U24 AG026395NIA NIH HHS U24 AG041689NIA NIH HHS U24 AG056270NIA NIH HHS U24 AG072122NIDDK NIH HHS P30 DK063491NIDDK NIH HHS U01 DK066134NIMHD NIH HHS P20 MD000546NINDS NIH HHS P50 NS039764NINDS NIH HHS R01 NS017950NINDS NIH HHS R01 NS059873NINDS NIH HHS R01 NS080820NINDS NIH HHS R01 NS118146NINDS NIH HHS U24 NS072026NINDS NIH HHS UH2 NS100605Wellcome Trust
6 · The paper itself

Abstract

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.

Indexed as

Alzheimer DiseaseCognitive DysfunctionGenome-Wide Association StudyHumanstau Proteinstau Proteins

Identifiers

PMID35379992
PMCPMC9005347
OpenAlexW4223591189

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