Evidence map›Paper›PMID 35379829›Full record

ArticleScientific reports2022

Monocyte subpopulation profiling indicates CDK6-derived cell differentiation and identifies subpopulation-specific miRNA expression sets in acute and stable coronary artery disease.

Anika Witten, Leonie Martens, Ann-Christin Schäfer, Christian Troidl, Sabine Pankuweit, Ann-Kathrin Vlacil, Raghav Oberoi, Bernhard Schieffer, Karsten Grote, Monika Stoll and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Decreased circulating CTRP3 levels in acute and chronic cardiovascular patients.Journal of molecular medicine (Berlin, Germany) · 2024
    Article
  5. Article
  6. Article
  7. The role of monocytes in thrombotic diseases: a review.Frontiers in cardiovascular medicine · 2023
    Review
  8. Article
  9. Analysis of miRNA Associated with Coronary Artery Calcification.Computational and mathematical methods in medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Anika Witten *Genetic Epidemiology, Institute for Human Genetics, Westfälische Wilhelms-University, Domagkstraße 3, 48149, Münster, Germany.
Leonie Martens *Genetic Epidemiology, Institute for Human Genetics, Westfälische Wilhelms-University, Domagkstraße 3, 48149, Münster, Germany.
Ann-Christin SchäferDepartment of Cardiology and Angiology, Philipps-University Marburg, Marburg, Germany.
Christian TroidlDepartment of Experimental Cardiology, Justus-Liebig-University, Giessen, Germany.
Sabine PankuweitDepartment of Cardiology and Angiology, Philipps-University Marburg, Marburg, Germany.
Ann-Kathrin VlacilDepartment of Cardiology and Angiology, Philipps-University Marburg, Marburg, Germany.
Raghav OberoiDepartment of Cardiology and Angiology, Philipps-University Marburg, Marburg, Germany.
Bernhard SchiefferDepartment of Cardiology and Angiology, Philipps-University Marburg, Marburg, Germany.
Karsten GroteDepartment of Cardiology and Angiology, Philipps-University Marburg, Marburg, Germany.
Monika Stoll *Genetic Epidemiology, Institute for Human Genetics, Westfälische Wilhelms-University, Domagkstraße 3, 48149, Münster, Germany. mstoll@uni-muenster.de.
Birgit Markus *Department of Cardiology and Angiology, Philipps-University Marburg, Marburg, Germany.
Philipps University of Marburg · DEUniversity of Münster · DEMaastricht University · NLUniversity of Giessen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronary artery disease (CAD) is a long-lasting inflammatory disease characterized by monocyte migration into the vessel wall leading to clinical events like myocardial infarction (MI). However, the role of monocyte subsets, especially their miRNA-driven differentiation in this scenario is still in its infancy. Here, we characterized monocyte subsets in controls and disease phenotypes of CAD and MI patients using flow cytometry and miRNA and mRNA expression profiling using RNA sequencing. We observed major differences in the miRNA profiles between the classical (CD14

Indexed as

Coronary Artery DiseaseMicroRNAsMyocardial InfarctionCell DifferentiationCyclin-Dependent Kinase 6HumansMonocytesReceptors, IgGCDK6 protein, humanCyclin-Dependent Kinase 6MicroRNAsReceptors, IgG

Identifiers

PMID35379829
PMCPMC8979987
OpenAlexW4226161666

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.