Evidence map›Paper›PMID 35379807›Full record

ArticleNature communications2022

Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function.

Liad Hinden, Majdoleen Ahmad, Sharleen Hamad, Alina Nemirovski, Gergő Szanda, Sandra Glasmacher, Aviram Kogot-Levin, Rinat Abramovitch, Bernard Thorens, Jürg Gertsch and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Integrative Approaches to Treating Cellular Senescence in Kidney Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Article
  3. Frontiers in pharmacology · 2026
    Article
  4. Genetic Tools in Rodents to Study Cannabinoid Functions.Current topics in behavioral neurosciences · 2026
    Review
  5. Article
  6. Hepatic CB1 receptor signaling triggers GMetabolism: clinical and experimental · 2025
    Article
  7. Article
  8. The effects of cannabinoids on the kidney.Acta physiologica (Oxford, England) · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Cannabinoid Signaling in the Diabetic Proximal Tubule: Of Mice and Men.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023
    Article
  16. Article
  17. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Liad HindenObesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID 0000-0002-0307-4350
Majdoleen AhmadObesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Sharleen HamadObesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Alina NemirovskiObesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Gergő SzandaDepartment of Physiology, Semmelweis University, Budapest, Hungary.
Sandra GlasmacherInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.
Aviram Kogot-LevinDiabetes Unit and Endocrine Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Rinat AbramovitchThe Wohl Institute for Translational Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.ORCID 0000-0003-1126-7467
Bernard ThorensCenter for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-3738-0129
Jürg GertschInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.ORCID 0000-0003-0978-1555
Gil LeibowitzDiabetes Unit and Endocrine Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.ORCID 0000-0002-9699-6353
Joseph TamObesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. yossi.tam@mail.huji.ac.il.ORCID 0000-0002-0948-0093
Hebrew University of Jerusalem · ILHadassah Medical Center · ILUniversity of Bern · CHSemmelweis University · HUUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activation of the cannabinoid-1 receptor (CB

Indexed as

Diabetic NephropathiesReceptor, Cannabinoid, CB1AnimalsKidneyKidney Tubules, ProximalMammalsMechanistic Target of Rapamycin Complex 1MiceMechanistic Target of Rapamycin Complex 1Receptor, Cannabinoid, CB1

Identifiers

PMID35379807
PMCPMC8980033
OpenAlexW4224213725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.