Evidence map›Paper›PMID 35379599›Full record

ArticleThe British journal of ophthalmology2023

Evaluation of the Nallasamy formula: a stacking ensemble machine learning method for refraction prediction in cataract surgery.

Tingyang Li, Joshua Stein, Nambi Nallasamy

Open access · hybridAbstract read
In one paragraph

Article in The British journal of ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tingyang LiDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-2559-184X
Joshua SteinKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA.
Nambi NallasamyDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA nnallasa@med.umich.edu.ORCID 0000-0001-7501-7198
University of Michigan · US

Funding

Michigan Vision Clinician Scientist Development ProgramK12EY022299 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Abigail Fahim, DAVID N ZACKS · 2013 to 2026
$6.3M
Personalized Forecasting of Disease Trajectory for Patients with Open Angle GlaucomaR01EY026641 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAVIERI-WILLIAMS, MARIEL SOFIA, STEIN, JOSHUA D · 2016 to 2020
$2.9M
Health Evaluation and Access to Leverage Technology for Improved DR Outcomes (HEAL-DR)R01EY036341 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DUSTIN D. FRENCH, Joshua D Stein · 2024 to 2026
$2.1M
NEI NIH HHS K12 EY022299NEI NIH HHS R01 EY026641NEI NIH HHS R01 EY036341
6 · The paper itself

Abstract

aimsTo develop a new intraocular lens power selection method with improved accuracy for general cataract patients receiving Alcon SN60WF lenses. METHODS AND ANALYSIS: A total of 5016 patients (6893 eyes) who underwent cataract surgery at University of Michigan's Kellogg Eye Center and received the Alcon SN60WF lens were included in the study. A machine learning-based method was developed using a training dataset of 4013 patients (5890 eyes), and evaluated on a testing dataset of 1003 patients (1003 eyes). The performance of our method was compared with that of Barrett Universal II, Emmetropia Verifying Optical (EVO), Haigis, Hoffer Q, Holladay 1, PearlDGS and SRK/T.

resultsMean absolute error (MAE) of the Nallasamy formula in the testing dataset was 0.312 Dioptres and the median absolute error (MedAE) was 0.242 D. Performance of existing methods were as follows: Barrett Universal II MAE=0.328 D, MedAE=0.256 D; EVO MAE=0.322 D, MedAE=0.251 D; Haigis MAE=0.363 D, MedAE=0.289 D; Hoffer Q MAE=0.404 D, MedAE=0.331 D; Holladay 1 MAE=0.371 D, MedAE=0.298 D; PearlDGS MAE=0.329 D, MedAE=0.258 D; SRK/T MAE=0.376 D, MedAE=0.300 D. The Nallasamy formula performed significantly better than seven existing methods based on the paired Wilcoxon test with Bonferroni correction (p<0.05).

conclusionsThe Nallasamy formula (available at https://lenscalc.com/) outperformed the seven other formulas studied on overall MAE, MedAE, and percentage of eyes within 0.5 D of prediction. Clinical significance may be primarily at the population level.

Indexed as

CataractLenses, IntraocularPhacoemulsificationAxial Length, EyeBiometryHumansOptics and PhotonicsRefraction, OcularRetrospective StudiesVisual AcuityLens and zonulesOptics and Refraction

Identifiers

PMID35379599
PMCPMC9530066
OpenAlexW4226085638

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.