Evidence map›Paper›PMID 35379353›Full record

ArticleActa neuropathologica communications2022

Differential vulnerability of hippocampal CA3-CA1 synapses to Aβ.

Olivia A Shipton, Clara S Tang, Ole Paulsen, Mariana Vargas-Caballero

Open access · goldAbstract read
In one paragraph

Article in Acta neuropathologica communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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  7. Application of Optogenetics in Neurodegenerative Diseases.Cellular and molecular neurobiology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Olivia A ShiptonDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.
Clara S TangDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.ORCID 0000-0001-6430-5573
Ole PaulsenDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK. op210@cam.ac.uk.ORCID 0000-0002-2258-5455
Mariana Vargas-CaballeroSchool of Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, SO17 1BJ, UK. M.Vargas-Caballero@soton.ac.uk.ORCID 0000-0003-2326-4001
University of Cambridge · GBUniversity of Southampton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyloid-beta (Aβ) and tau protein are both involved in the pathogenesis of Alzheimer's disease. Aβ produces synaptic deficits in wild-type mice that are not seen in Mapt

Indexed as

Alzheimer DiseaseHippocampusSynapsesAmyloid beta-PeptidesAnimalsCA1 Region, HippocampalCA3 Region, HippocampalLong-Term PotentiationMiceAmyloid beta-PeptidesAlzheimer’s diseaseAsymmetryHippocampusOptogeneticsSynapseTau

Identifiers

PMID35379353
PMCPMC8981624
OpenAlexW4224223736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.