ArticleCirculation. Cardiovascular interventions2022
Transcatheter Myotomy to Relieve Left Ventricular Outflow Tract Obstruction: The Septal Scoring Along the Midline Endocardium Procedure in Animals.
Article in Circulation. Cardiovascular interventions, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- A systematic review of present and future pharmaco-structural therapies for hypertrophic cardiomyopathy.Clinical cardiology · 2024Pooled it
- BATMAN-Assisted Valve-in-Valve TMVR With Planned Hemodynamic Support in Severe Pulmonary Hypertension.JACC. Case reports · 2026Article
- Early Experience With the Septal Scoring Along the Midline Endocardium (SESAME) Technique in the Asia-Pacific Region.JACC. Case reports · 2026Article
- Adapting Interventional Echocardiography to New Techniques: Echocardiographic Guidance for Transcatheter Myotomy Using Septal Scoring Along the Midline Endocardium.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2026Article
- Review
- Transcatheter mitral valve options for severe mitral annular calcification.Annals of cardiothoracic surgery · 2025Review
- Article
- SESAME technique: septal scoring along the midline endocardium.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Article
- Management of complications after valvular interventions.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Review
- Ventricular intramyocardial navigation for tachycardia ablation guided by electrograms for left ventricular summit arrythmia in a human.HeartRhythm case reports · 2025Article
- Transseptal Balloon-Assisted Translocation of Mitral Leaflet for Mitral Calcification: A First in Human Experience.JACC. Case reports · 2025Article
- Emerging Pharmacological and Invasive Therapies for Hypertrophic Cardiomyopathy with Obstructive Physiology.Cardiac failure review · 2025Review
- Transcatheter Myotomy for Hypertrophic Obstructive Cardiomyopathy.Current cardiology reports · 2024Review
- Modern Perspectives on Hypertrophic Cardiomyopathy-No One Size Fits All.Texas Heart Institute journal · 2024Review
- Left Ventricular Outflow Tract and Transcatheter Mitral Valve Replacement Obstruction and TMVR: Predictors, Evaluation, and Solutions.Structural heart : the journal of the Heart Team · 2024Review
- Ventricular Intramyocardial Navigation for Tachycardia Ablation Guided by Electrograms (VINTAGE): Deep Ablation in Inaccessible Targets.JACC. Clinical electrophysiology · 2024Article
- Transcatheter Myotomy to Reduce Left Ventricular Outflow Obstruction.Journal of the American College of Cardiology · 2024Article
- Mitral Regurgitation and Left Ventricular Outflow Tract Obstruction: Confluence of Challenges for Transcatheter Treatment.Reviews in cardiovascular medicine · 2024Review
- Transseptal BATMAN for High-Risk Valve-in-Ring Procedures: A Case Series.JACC. Case reports · 2024Article
- Transcatheter Aortic Valve Implantation to Treat Degenerated Aortic, Mitral and Tricuspid Bioprosthesis.Journal of clinical medicine · 2024Review
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundLeft ventricular outflow tract obstruction complicates hypertrophic cardiomyopathy and transcatheter mitral valve replacement. Septal reduction therapies including surgical myectomy and alcohol septal ablation are limited by surgical morbidity or coronary anatomy and high pacemaker rates, respectively. We developed a novel transcatheter procedure, mimicking surgical myotomy, called Septal Scoring Along the Midline Endocardium (SESAME).
methodsSESAME was performed in 5 naive pigs and 5 pigs with percutaneous aortic banding-induced left ventricular hypertrophy. Fluoroscopy and intracardiac echocardiography guided the procedures. Coronary guiding catheters and guidewires were used to mechanically enter the basal interventricular septum. Imparting a tip bend to the guidewire enabled intramyocardial navigation with multiple
resultsSESAME myotomy along the intended trajectory was achieved in all animals. The myocardium splayed after laceration, increasing left ventricular outflow tract area (753 to 854 mm
conclusionsThis preclinical study demonstrated feasibility of SESAME, a novel transcatheter myotomy to relieve left ventricular outflow tract obstruction. This percutaneous procedure using available devices, with a safe surgical precedent, is readily translatable into patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.