ArticleCirculation. Heart failure2022
Skeletal Muscle Mass Recovery Early After Left Ventricular Assist Device Implantation in Patients With Advanced Systolic Heart Failure.
Article in Circulation. Heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Sarcopenia and cardiovascular diseases: A systematic review and meta-analysis.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- Technological advances and clinical application of left ventricular assist devices in the treatment of advanced heart failure.Journal of cardiothoracic surgery · 2026Review
- From Continuous-Flow Mechanical Circulatory Support to Heart Transplantation: Hemodynamic, Immunometabolic, and Body Composition Determinants of Rehabilitation Outcomes.Journal of clinical medicine · 2026Review
- International Utah cardiac recovery symposium (U-CARS) 2025:translational and basic science proceedings.Heart failure reviews · 2026Review
- Skeletal Muscle Strength in Patients on the Heart Transplant Waiting List: Are There Any Associations with Instrumental Examination Data?Journal of clinical medicine · 2026Article
- Kidney Function Recovery After Left Ventricular Assist Device Implantation: A Transient Hemodynamic Effect or an Artifact?Kidney international reports · 2025Article
- Evaluation of potential mechanisms for skeletal muscle mass recovery early after left ventricular assist device implantation.JHLT open · 2025Article
- Malnutrition risk, weight loss, and subsequent survival in patients listed for heart transplantation.JHLT open · 2025Article
- Towards Metabolomic-Based Precision Approaches for Classifying and Treating Heart Failure.JACC. Basic to translational science · 2024Review
- The left ventricular assist device 'skeleton man': case report-simple tools for skeletal muscle evaluation and very early aerobic/resistance/inspiratory training in cardiac cachexia.European heart journal. Case reports · 2024Article
- Computed tomography-based body composition parameters can predict short-term prognosis in ulcerative colitis patients.Insights into imaging · 2024Article
- Pectoral muscle mass is not a robust prognostic factor for survival after left ventricular assist device (LVAD) implantation.Journal of cardiothoracic surgery · 2024Article
- Artificial intelligence-based analysis of body composition predicts outcome in patients receiving long-term mechanical circulatory support.Journal of cachexia, sarcopenia and muscle · 2024Article
- Skeletal muscle atrophy, regeneration, and dysfunction in heart failure: Impact of exercise training.Journal of sport and health science · 2023Review
- Cardiac Cachexia in Left Ventricular Assist Device Recipients and the Implications of Weight Gain Early After Implantation.Journal of the American Heart Association · 2023Article
- Hyoid Bone Syndrome in a Patient Undergoing Left Ventricular Assist Device Implantation.Healthcare (Basel, Switzerland) · 2023Article
- Left Ventricular Assist Devices and Renal Ramifications.Journal of the American Heart Association · 2023Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPatients with advanced systolic heart failure are at risk of unintentional weight loss and muscle wasting. It has been observed that left ventricular assist device (LVAD) recipients gain weight after device implantation, although it is unknown whether this represents skeletal muscle mass gains. We aimed to determine whether skeletal muscle mass increases early during LVAD support.
methodsWe prospectively recruited 30 adults with systolic heart failure ±21 days from LVAD implantation. Participants underwent whole-body dual X-ray absorptiometry to measure fat free mass, appendicular lean mass (ALM, lean mass in the arms and legs) and fat mass. Dual X-ray absorptiometry imaging was repeated at 3 and 6 months after LVAD implantation, with participation ending after the 6-month visit or heart transplantation, whichever occurred first. Changes in body composition were evaluated using mixed effects linear regression models.
resultsThe cohort was 87% male, with mean age 56±12 (SD) years, and mean body mass index 26.4±5.4 kg/m
conclusionsAmong LVAD recipients with advanced systolic heart failure and high baseline prevalence of muscle wasting, there were significant gains in skeletal muscle mass, as represented by dual X-ray absorptiometry fat free mass and ALM, over the first 6 months of LVAD support.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.