Evidence map›Paper›PMID 35378880›Full record

ArticleInternational journal of nanomedicine2022

Thermosensitive Tri-Block Polymer Nanoparticle-Hydrogel Composites as Payloads of Natamycin for Antifungal Therapy Against

Xiaoyuan Sha, Leung Chan, Xiaoyi Fan, Penghao Guo, Tianfeng Chen, Lian Liu, Jingxiang Zhong

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Xiaoyuan ShaDepartment of Ophthalmology, The First Affiliated Hospital, and Department of Chemistry, Jinan University, Guangzhou, People's Republic of China.
Leung ChanDepartment of Ophthalmology, The First Affiliated Hospital, and Department of Chemistry, Jinan University, Guangzhou, People's Republic of China.
Xiaoyi FanDepartment of Clinical Laboratory, The First Affiliated Hospital of Jinan University, Guangzhou, People's Republic of China.
Penghao GuoDepartment of Clinical Laboratory, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Tianfeng ChenDepartment of Ophthalmology, The First Affiliated Hospital, and Department of Chemistry, Jinan University, Guangzhou, People's Republic of China.
Lian LiuDepartment of Ophthalmology, The First Affiliated Hospital, and Department of Chemistry, Jinan University, Guangzhou, People's Republic of China.ORCID 0000-0002-5853-6268
Jingxiang ZhongDepartment of Ophthalmology, The First Affiliated Hospital, and Department of Chemistry, Jinan University, Guangzhou, People's Republic of China.ORCID 0000-0002-5774-7602
First Affiliated Hospital of Jinan University · CNJinan University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Methods: PLGA-PEI-PEG@NAT was prepared and characterized with a nano-particle size analyzer, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR). The minimum inhibitory concentration (MIC), cytotoxicity, penetrability of NAT (Natacyn Results: PLGA-PEI-PEG@NAT had a particle size of 150 nm, a positive surface charge, and a sustained-release effect. The MIC for Conclusion: Gel@PLGA-PEI-PEG@NAT was shown to be a safe and effective nanodrug delivery system for NAT. It has great potential to improve the cure rate of fungal keratitis, reduce the administration frequency during the treatment process, and improve patient compliance.

Indexed as

NanoparticlesNatamycinAnimalsAntifungal AgentsFusariumHydrogelsPolyethylene GlycolsPolymersRabbitsAntifungal AgentsHydrogelsNatamycinPolyethylene GlycolsPolymersfungal keratitisnanoparticlesnatamycinocular drug deliverytri-block polymer

Identifiers

PMID35378880
PMCPMC8976233
OpenAlexW4221100103

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.