Evidence map›Paper›PMID 35378797›Full record

ArticleAmerican heart journal plus : cardiology research and practice2022

Utility of exercise testing to assess athletes for post COVID-19 myocarditis.

R D Mitrani, J Alfadhli, M H Lowery, T M Best, J M Hare, J Fishman, C Dong, Y Siegel, V Scavo, G J Basham and 2 more

Open access · goldAbstract read
In one paragraph

Article in American heart journal plus : cardiology research and practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

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  4. Guideline on Stress Echocardiography - 2026.Arquivos brasileiros de cardiologia · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

R D MitraniDepartment of Medicine, University of Miami, Miller School of Medicine, United States of America.
J AlfadhliDepartment of Medicine, University of Miami, Miller School of Medicine, United States of America.
M H LoweryDepartment of Medicine, University of Miami, Miller School of Medicine, United States of America.
T M BestUHealth Sports Medicine Institute, Department of Orthopedics, University of Miami, Miller School of Medicine, United States of America.
J M HareDepartment of Medicine, University of Miami, Miller School of Medicine, United States of America.
J FishmanDepartment of Radiology, University of Miami, Miller School of Medicine, United States of America.
C DongDepartment of Neurology, University of Miami, Miller School of Medicine, United States of America.
Y SiegelDepartment of Radiology, University of Miami, Miller School of Medicine, United States of America.
V ScavoDepartment of Intercollegiate Athletics, University of Miami, United States of America.
G J BashamMiami Marlins, United States of America.
R J MyerburgDepartment of Medicine, University of Miami, Miller School of Medicine, United States of America.
J J GoldbergerDepartment of Medicine, University of Miami, Miller School of Medicine, United States of America.
University of Miami · USUniversity of Miami Health System · US

Funding

ROLE OF Rac AND REACTIVE OXYGEN SPECIES IN KAPOSI'S SARCOMA VIRAL ONCOGENESISR01CA136387 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SHEMBADE, NOULA DATTU · 2010 to 2024
$7.1M
Cardioprotective Effect of Growth Hormone Releasing HormoneR01HL107110 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HARE, JOSHUA M · 2011 to 2020
$5.9M
Cell Based Therapy for Non-Ischemic Dilated CardiomyopathyUM1HL113460 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HARE, JOSHUA M · 2012 to 2018
$4.3M
Mesenchymal stem cell therapy for endothelial dysfunction in diabetesR01HL134558 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HARE, JOSHUA M · 2016 to 2020
$3.2M
NCI NIH HHS R01 CA136387NHLBI NIH HHS R01 HL107110NHLBI NIH HHS R01 HL134558NHLBI NIH HHS UM1 HL113460
6 · The paper itself

Abstract

Purpose: This study assessed a functional protocol to identify myocarditis or myocardial involvement in competitive athletes following SARS-CoV2 infection. Methods: We prospectively evaluated competitive athletes (n = 174) for myocarditis or myocardial involvement using the Multidisciplinary Inquiry of Athletes in Miami (MIAMI) protocol, a median of 18.5 (IQR 16-25) days following diagnosis of COVID-19 infection. The protocol included biomarker analysis, ECG, cardiopulmonary stress echocardiography testing with global longitudinal strain (GLS), and targeted cardiac MRI for athletes with abnormal findings. Patients were followed for median of 148 days. Results: We evaluated 52 females and 122 males, with median age 21 (IQR: 19, 22) years. Five (2.9%) had evidence of myocardial involvement, including definite or probable myocarditis (n = 2). Three of the 5 athletes with myocarditis or myocardial involvement had clinically significant abnormalities during stress testing including ventricular ectopy, wall motion abnormalities and/or elevated VE/VCO2, while the other two athletes had resting ECG abnormalities. VO2 Conclusions: Screening protocols that include exercise testing may enhance the sensitivity of detecting COVID-19 related myocardial involvement following recovery from SARS-CoV2 infection.

Indexed as

Cardiac injuryCardiac MRICovid-19CPET, cardiopulmonary exercise testECG, electrocardiogramECHO, echocardiogramEF, ejection fractionGLS, global longitudinal strainLGE, late gadolinium enhancementLV, left ventricularMIAMI, Multidisciplinary Inquiry of Athletes in Miami In COVID-19 recoveryMRI, magnetic resonance imagingMyocarditisVentricular arrhythmia

Identifiers

PMID35378797
PMCPMC8968209
OpenAlexW4221041781

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.