Evidence map›Paper›PMID 35378747›Full record

ArticlebioRxiv : the preprint server for biology2022

Repeated ethanol exposure and withdrawal alters ACE2 expression in discrete brain regions: Implications for SARS-CoV-2 infection.

Nagalakshmi Balasubramanian, Thomas D James, Selvakumar Govindhasamy Pushpavathi, Catherine A Marcinkiewcz

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nagalakshmi BalasubramanianDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA-52242, USA.
Thomas D JamesDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA-52242, USA.
Selvakumar Govindhasamy PushpavathiDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA-52242, USA.
Catherine A MarcinkiewczDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA-52242, USA.
University of Iowa · US

Funding

Multidisciplinary Lung Research Career Development ProgramT32HL007638 · NHLBI · UNIVERSITY OF IOWA · PI WELSH, MICHAEL J., ZABNER, JOSEPH · 1986 to 2020
$16.9M
The role of serotonin signaling in the nucleus accumbens in excessive alcohol drinkingR00AA024215 · NIAAA · UNIVERSITY OF IOWA · PI MARCINKIEWCZ, CATHERINE ANNE · 2019 to 2021
$1.3M
NHLBI NIH HHS T32 HL007638NIAAA NIH HHS R00 AA024215
6 · The paper itself

Abstract

Emerging evidence suggests that people with alcohol use disorders are at higher risk for SARS-CoV-2. SARS-CoV-2 engages angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) receptors for cellular entry. While ACE2 and TMPRSS2 genes are upregulated in the cortex of alcohol-dependent individuals, information on expression in specific brain regions and neural populations implicated in SARS-CoV-2 neuroinvasion, particularly monoaminergic neurons, is limited. We sought to clarify how chronic alcohol exposure affects

Identifiers

PMID35378747
PMCPMC8978936
OpenAlexW4220913945

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.