ArticlePharmaceutical research2022
Re-writing Oral Pharmacokinetics Using Physiologically Based Finite Time Pharmacokinetic (PBFTPK) Models.
Article in Pharmaceutical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A structure-preserving hybrid learning framework for compartmental pharmacokinetic models.Journal of pharmacokinetics and pharmacodynamics · 2026Article
- Physiologically Based Pharmacokinetic (PBPK) Modeling of Oral Drug Absorption for Integrating Nonclinical Data into Human Pharmacokinetic Predictions.The AAPS journal · 2026Review
- Biopharmaceutic Assessment of Post-Approval Changes for Azithromycin Immediate Release Tablets Using Predictive In Vitro Dissolution and a Model-Informed Approach.Pharmaceutical research · 2026Article
- Formulation, development and characterization of fosfomycin tromethamine pessaries for the treatment of vaginal infections.Scientific reports · 2025Article
- The Finite Absorption Time Concept Guiding Model Informed Drug & Generics Development in Clinical Pharmacology.Pharmaceutical research · 2025Review
- Time Scale Calculus: a new approach to multi-dose pharmacokinetic modeling.Journal of pharmacokinetics and pharmacodynamics · 2024Article
- FDA and EMA Oversight of Disruptive Science on Application of Finite Absorption Time (F.A.T.) Concept in Oral Drug Absorption: Time for Scientific and Regulatory Changes.Pharmaceutics · 2024Article
- Application of the Finite Absorption Time (F.A.T.) Concept in the Assessment of Bioequivalence.Pharmaceutical research · 2024Article
- Importance of Considering Fed-State Gastrointestinal Physiology in Predicting the Reabsorption of Enterohepatic Circulation of Drugs.Pharmaceutical research · 2024Article
- Coupling Drug Dissolution with BCS.Pharmaceutical research · 2024Article
- IVIVC Revised.Pharmaceutical research · 2024Article
- Is the One-Compartment Model with First Order Absorption a Useful Approximation?Pharmaceutical research · 2023Article
- Revamping Biopharmaceutics-Pharmacokinetics with Scientific and Regulatory Implications for Oral Drug Absorption.Pharmaceutical research · 2023Article
- Re-examining Naloxone Pharmacokinetics After Intranasal and Intramuscular Administration Using the Finite Absorption Time Concept.European journal of drug metabolism and pharmacokinetics · 2023Article
- An Analytical Solution for Saturable Absorption in Pharmacokinetics Models.Pharmaceutical research · 2023Article
- Physiologically based Pharmacokinetic Models under the Prism of the Finite Absorption Time Concept.Pharmaceutical research · 2023Article
- The Finite Absorption Time (FAT) concept en route to PBPK modeling and pharmacometrics.Journal of pharmacokinetics and pharmacodynamics · 2023Article
- Effect of Excessive Serotonin on Pharmacokinetics of Cephalexin after Oral Administration: Studies with Serotonin-Excessive Model Rats.Pharmaceutical research · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo develop physiologically based finite time pharmacokinetic (PBFTPK) models for the analysis of oral pharmacokinetic data.
methodsThe models are based on the passive drug diffusion mechanism under the sink conditions principle. Up to three drug successive input functions of constant rate operating for a total time τ are considered. Differential equations were written for all these models assuming linear one- or two-compartment-model disposition. The differential equations were solved and functions describing the concentration of drug as a function of time for the central and the peripheral compartment were derived. The equations were used to generate simulated data and they were also fitted to a variety of experimental literature oral pharmacokinetic data.
resultsThe simulated curves resemble real life data. The end of the absorption processes τ is either equal to t
conclusionsThe PBFTPK models are a powerful tool for the analysis of oral pharmacokinetic data since they rely on the physiologically sound concept of finite absorption time.
Indexed as
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35378697What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.