ArticleNeurocritical care2022
Cortical Spreading Depolarization, Blood Flow, and Cognitive Outcomes in a Closed Head Injury Mouse Model of Traumatic Brain Injury.
Article in Neurocritical care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Behavioral Deficits and Cortical Network Dysfunction Following Repeated Mild Traumatic Brain Injuries.Journal of neurotrauma · 2026Article
- Cortical spreading depression and multi-territorial cortical infarction following traumatic subdural hematoma: A case report and literature review.Surgical neurology international · 2026Article
- Specific pre-injury migraine characteristics associated with worse concussion outcomes.PloS one · 2026Article
- Raised intracranial pressure alters cortical vascular function and cephalic allodynia.Brain : a journal of neurology · 2025Article
- Pharmacological inhibition of all known major inward cationic currents does not block the induction of spreading depolarizations.Frontiers in cellular neuroscience · 2025Article
- Behavioral and Cognitive Consequences of Spreading Depolarizations: A Translational Scoping Review.Journal of neurotrauma · 2025Article
- From spreading depolarization to blood-brain barrier dysfunction: navigating traumatic brain injury for novel diagnosis and therapy.Nature reviews. Neurology · 2024Review
- Spreading Depolarizations Contribute to the Acute Behavior Deficits Associated With a Mild Traumatic Brain Injury in Mice.Journal of neurotrauma · 2024Article
- Introduction to Spreading Depolarizations Special Edition Volume 2.Neurocritical care · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCortical spreading depolarizations (CSDs) are associated with worse outcomes in many forms of acute brain injury, including traumatic brain injury (TBI). Animal models could be helpful in developing new therapies or biomarkers to improve outcomes in survivors of TBI. Recently, investigators have observed CSDs in murine models of mild closed head injury (CHI). We designed the currently study to determine additional experimental conditions under which CSDs can be observed, from mild to relatively more severe TBI.
methodsAdult male C57Bl/6J mice (8-14 weeks old) were anesthetized with isoflurane and subjected to CHI with an 81-g weight drop from 152 or 183 cm. CSDs were detected with minimally invasive visible light optical intrinsic signal imaging. Cerebral blood flow index (CBFi) was measured in the 152-cm drop height cohort using diffuse correlation spectroscopy at baseline before and 4 min after CHI. Cognitive outcomes were assessed at 152- and 183-cm drop heights for the Morris water maze hidden platform, probe, and visible platform tests.
resultsCSDs occurred in 43% (n = 12 of 28) of 152-cm and 58% (n = 15 of 26) of 183-cm drop height CHI mice (p = 0.28). A lower baseline preinjury CBFi was associated with development of CSDs in CHI mice (1.50 ± 0.07 × 10
conclusionsThe data suggest that a lower baseline cerebral blood flow prior to injury may contribute to the occurrence of a CSD. Furthermore, a CSD at the time of injury can be associated with worse cognitive outcome under the appropriate experimental conditions in a mouse CHI model of TBI.
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