Evidence map›Paper›PMID 35378621›Full record

ArticleJournal of the Association for Research in Otolaryngology : JARO2022

Differential Activation of Canal and Otolith Afferents by Acoustic Tone Bursts in Rats.

Jun Huang, Xuehui Tang, Youguo Xu, Chunming Zhang, Tianwen Chen, Yue Yu, William Mustain, Jerome Allison, Marta M Iversen, Richard D Rabbitt and 2 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Association for Research in Otolaryngology : JARO, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Jun HuangDepartment of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Xuehui TangDepartment of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Youguo XuDepartment of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Chunming ZhangDepartment of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Tianwen ChenDepartment of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Yue YuDepartment of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
William MustainDepartment of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Jerome AllisonDepartment of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Marta M IversenDepartment of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA.
Richard D RabbittDepartment of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA.
Wu ZhouDepartment of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA. wzhou@umc.edu.ORCID 0000-0001-5600-0112
Hong ZhuDepartment of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA. hozhu@umc.edu.
Jackson Memorial Hospital · USUniversity of Utah · USShanxi Medical University · CN

Funding

Neural mechanisms of sound activation of vestibular systemR01DC012060 · NIDCD · UNIVERSITY OF MISSISSIPPI MED CTR · PI ZHU, HONG · 2012 to 2016
$1.9M
Multiplicative computation in the vestibulo-ocular reflex (VOR)R01DC008585 · NIDCD · UNIVERSITY OF MISSISSIPPI MED CTR · PI ZHOU, WU · 2007 to 2011
$1.4M
NIDCD NIH HHS R01 DC008585NIDCD NIH HHS R01 DC012060
6 · The paper itself

Abstract

Vestibular evoked myogenic potentials (VEMPs) are routinely used to test otolith function, but which specific vestibular afferent neurons and central circuits are activated by auditory frequency VEMP stimuli remains unclear. To examine this question, we analyzed the sensitivity of individual vestibular afferents in adult Sprague-Dawley rats to tone bursts delivered at 9 frequencies (125-4000 Hz) and 3 intensity levels (60, 70, 80 dB SL re: acoustic brainstem response (ABR) threshold). Afferent neuron tone sensitivity was quantified by the cumulative probability of evoking a spike (CPE). Based on a threshold CPE of 0.1, acoustic stimuli in the present study evoked responses in 78.2 % (390/499) of otolith afferent neurons vs. 48.4 % (431/891) of canal afferent neurons. Organ-specific vestibular inputs to the central nervous system in response to tone bursts differ based on intensity and frequency content of the stimulus. At frequencies below 500 Hz, tone bursts primarily activated both otolith afferents, even at the highest intensity tested (80 dB SL re ABR threshold). At 1500 Hz, however, tone bursts activated the canal and otolith afferents at the moderate and high intensities tested (70, 80 dB SL), but activated only otolith afferents at the low intensity tested (60 dB SL). Within an end organ, diversity of sensitivity between individual afferent neurons correlated with spontaneous discharge rate and regularity. Examination of inner ear fluid mechanics in silico suggests that the frequency response and preferential activation of the otolith organs likely arise from inner ear fluid motion trapped near the oval and round windows. These results provide insight into understanding the mechanisms of sound activation of the vestibular system and developing novel discriminative VEMP testing protocols and interpretative guidelines in humans.

Indexed as

Otolithic MembraneVestibular Evoked Myogenic PotentialsAcousticsAcoustic StimulationAnimalsRatsRats, Sprague-Dawleyotolithsemicircular canalsVEMPvestibular afferentsvestibular evoked myogenic potentialsvestibulo-collic reflexvestibulo-ocular reflex

Identifiers

PMID35378621
PMCPMC9086073
OpenAlexW4225922590

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.