Evidence map›Paper›PMID 35378230›Full record

Trial reportBrain, behavior, and immunity2022

Breast cancer survivors' typhoid vaccine responses: Chemotherapy, obesity, and fitness make a difference.

Janice K Kiecolt-Glaser, Megan Renna, Juan Peng, John Sheridan, Maryam Lustberg, Bhuvaneswari Ramaswamy, Robert Wesolowski, Jeffrey B VanDeusen, Nicole O Williams, Sagar D Sardesai and 6 more

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Brain, behavior, and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
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  3. Stimulated cytokine production, attachment, and emotional well-being in dementia spousal caregivers.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Janice K Kiecolt-GlaserInstitute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH, United States; Department of Psychiatry and Behavioral Health, The Ohio State University College of Medicine, Columbus, OH, United States. Electronic address: Janice.Kiecolt-Glaser@osumc.edu.
Megan RennaSchool of Psychology, University of Southern Mississippi, Hattiesburg, MS, United States.
Juan PengCenter for Biostatistics, Department of Biomedical Informatics, The Ohio State University, College of Medicine, Columbus, OH, United States.
John SheridanInstitute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH, United States; Division of Biosciences, The Ohio State University College of Dentistry, Columbus, OH, United States.
Maryam LustbergYale School of Medicine, New Haven, CN, United States.
Bhuvaneswari RamaswamyDepartment of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, United States; Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, United States.
Robert WesolowskiDepartment of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, United States; Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, United States.
Jeffrey B VanDeusenDepartment of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, United States; Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, United States.
Nicole O WilliamsDepartment of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, United States; Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, United States.
Sagar D SardesaiDepartment of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, United States; Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, United States.
Anne M NoonanDepartment of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, United States; Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, United States.
Raquel E ReinboltDepartment of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, United States; Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, United States.
Daniel G StoverDepartment of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, United States; Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, United States.
Mathew A CherianDepartment of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, United States; Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, United States.
William B MalarkeyInstitute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH, United States; Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, United States.
Rebecca AndridgeDivision of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH, United States.
The Ohio State University · USInstitute for Behavioral Medicine · USUniversity of Southern Mississippi · USYale University · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
The Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6M
Aerobic Capacity, Depression, & Inflammatory Responsivity in Cancer SurvivorsR01CA186251 · NCI · OHIO STATE UNIVERSITY · PI KIECOLT-GLASER, JANICE · 2015 to 2019
$3.1M
Biobehavioral Influences on Cancer: Perspectives from PsychoneuroimmunologyK05CA172296 · NCI · OHIO STATE UNIVERSITY · PI KIECOLT-GLASER, JANICE · 2013 to 2017
$426k
NCATS NIH HHS UL1 TR001070NCI NIH HHS K05 CA172296NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA186251
6 · The paper itself

Abstract

purposeTo investigate breast cancer survivors' inflammatory responses to typhoid vaccine as a window into their innate immune response to novel pathogens.

methodsThis double-blind crossover trial randomized 158 breast cancer survivors to either the vaccine/saline placebo or the placebo/vaccine sequence. The relative contributions of age, cardiorespiratory fitness (VO

resultsThe vaccine produced larger IL-6, IL-1Ra, and WBC responses than placebo, ps < 0.0001. Prior chemotherapy, higher central obesity, and lower VO

conclusionsThis study provided novel data on chemotherapy's longer-term adverse immune consequences. The data also have an important public health message: even relatively low levels of fitness can benefit the innate immune response to a vaccine.

Indexed as

Breast NeoplasmsCancer SurvivorsTyphoid-Paratyphoid VaccinesFemaleHumansInterleukin 1 Receptor Antagonist ProteinInterleukin-6ObesityObesity, AbdominalInterleukin 1 Receptor Antagonist ProteinInterleukin-6Typhoid-Paratyphoid Vaccines

Identifiers

PMID35378230
PMCPMC9149127
OpenAlexW4220735332

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.