Evidence map›Paper›PMID 35378081›Full record

ArticleBiophysical journal2022

Caveolin-3 prevents swelling-induced membrane damage via regulation of I

Daniel G P Turner, Leonid Tyan, Frank C DeGuire, Roman Y Medvedev, Sami J Stroebel, Di Lang, Alexey V Glukhov

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 6 citations in OpenAlex.

  1. Caveolae mechanics in cellular functions and disease.Nature reviews. Molecular cell biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Daniel G P TurnerDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Leonid TyanDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Frank C DeGuireDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Roman Y MedvedevDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Sami J StroebelDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Di LangDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Alexey V GlukhovDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin. Electronic address: aglukhov@medicine.wisc.edu.
University of Wisconsin–Madison · US

Funding

Training Program In Molecular AND Cellular PharmacologyT32GM008688 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI AUDHYA, ANJON · 1998 to 2020
$6.0M
Functional Microdomains in the Heart's Pacemaker: A New Dimension of Cardiac RemodelingR01HL141214 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Alexey V Glukhov · 2018 to 2026
$3.8M
NHLBI NIH HHS R01 HL141214NIGMS NIH HHS T32 GM008688
6 · The paper itself

Abstract

Caveola membrane structures harbor mechanosensitive chloride channels (MCCs; including chloride channel 2, chloride channel 3, and SWELL1, also known as LRRC8A) that form a swelling-activated chloride current (I

Indexed as

ChloridesAnimalsButyric AcidCaveolin 3Cell SizeChloride ChannelsHEK293 CellsHumansMembrane ProteinsMiceButyric AcidCAV3 protein, humanCav3 protein, mouseCaveolin 3Chloride ChannelsChloridesLRRC8A protein, humanLRRC8A protein, mouseMembrane Proteins

Identifiers

PMID35378081
PMCPMC9117929
OpenAlexW4223982279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.