Evidence map›Paper›PMID 35377967›Full record

Observational studyCancer cytopathology2022

Cytology interpretation after a change to HPV testing in primary cervical screening: Observational study from the English pilot.

Matejka Rebolj, Christopher S Mathews, Karin Denton, HPV Pilot Steering Group

Open access · hybridAbstract readObservational Study
In one paragraph

Observational study in Cancer cytopathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Application and Impact of Quality Assurance Dashboards in Cytology Laboratories-The CytoLog Application.Cytopathology : official journal of the British Society for Clinical Cytology · 2026
    Article
  2. Review
  3. How to evaluate and select cervical screening and triage tests in vaccinated populations.Journal of the National Cancer Institute. Monographs · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Matejka ReboljCancer Prevention Group, School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.ORCID 0000-0001-9597-645X
Christopher S MathewsCancer Prevention Group, School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.
Karin DentonSevern Pathology, Southmead Hospital, North Bristol NHS Trust, Bristol, United Kingdom.
HPV Pilot Steering GroupCancer Prevention Group, School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.
King's College London · GBNorth Bristol NHS Trust · GB

Funding

Cancer Research UK 27047Cancer Research UK C8162/A27047
6 · The paper itself

Abstract

backgroundOvercalling of abnormalities has been a concern for using cytology triage after positive high-risk human papillomavirus (HPV) tests in cervical screening.

methodsThe authors studied the detection of cytological and histological abnormalities at age 24 to 64 years, using data from the English HPV pilot. The pilot compared routine implementation of primary cervical screening based on cytology (N = 931,539), where HPV test results were not available before cytology reporting, with that based on HPV testing (N = 403,269), where cytology was only required after positive HPV tests.

resultsRevealed HPV positivity was associated with a higher direct referral to colposcopy after any abnormality (adjusted odds ratio [OR

conclusionsQuality-controlled cervical screening programs can avoid inappropriate overgrading of HPV-positive cytology.

Indexed as

Papillomavirus InfectionsUterine Cervical DysplasiaUterine Cervical NeoplasmsAdultColposcopyEarly Detection of CancerFemaleHumansMass ScreeningMiddle AgedPapillomaviridaePregnancyVaginal SmearsYoung Adultcytologymass screeningpapillomavirus infectionsuterine cervical neoplasms

Identifiers

PMID35377967
PMCPMC9542289
OpenAlexW4225727695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.